Cushie Calendar (Cushie)

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 27 Sep 2026 03:00:00 EST

(Sun, 27 Sep 2026 )

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Atypical Presentation of Cushing’s Disease With Weight Loss and Hypokalemia

Sun, 27 Sep 2026 05:00:00 EST

(Sun, 27 Sep 2026 )

Learning points

Patients with CD do not always present with classical clinical features and may present with symptoms and biochemical findings that would otherwise suggest ectopic ACTH production.
While most patients with CD typically lose weight after biochemical remission, some patients gain weight after the normalization of cortisol levels.
This case highlights the need to entertain a broad differential in patients presenting with hypokalemia and weight loss and the need to exclude hypercortisolemia.

https://cushings.invisionzone.com/topic/57760-atypical-presentation-of-cushing%E2%80%99s-disease-with-weight-loss-and-hypokalemia/

Sterotherapeutics Announces First Patient Dosed in Phase 2 Clinical Trial Evaluating ST-002 for Cushing's Syndrome

Sun, 27 Sep 2026 05:00:00 EST

(Sun, 27 Sep 2026 )

A clinical-stage biopharmaceutical company focused on rare endocrine diseases, announced that the first patient has been successfully dosed in its ongoing Phase 2 clinical trial evaluating ST-002 for the treatment of Cushing's Syndrome.

https://cushings.invisionzone.com/topic/57846-sterotherapeutics-announces-first-patient-dosed-in-phase-2-clinical-trial-evaluating-st-002-for-cushings-syndrome/

Dee (Dee), Pituitary Bio

Sun, 27 Sep 2026 05:00:00 EST

(Sun, 27 Sep 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

A few years passed and my blood pressure sky rocketed, my hair started falling out, my teeth were breaking and I was gaining weight and unable to stop it. I grew a heavy beard, black hairs on my arms and thighs. My face became distored, my head was pushed towards my feet from a hump on my back. I was losing the use of my legs, and unable to hold a pen or pencil. I started to look 7 months pregnant with a larged mid-section. I couldn’t retain simple instructions, and had to stop driving...

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Cushing’s Disease Patients are More Likely to Have Ocular Hypertension

Sun, 27 Sep 2026 06:00:00 EST

(Sun, 27 Sep 2026 )

Ocular hypertension was more common in people with Cushing’s illness. The usage of steroids in the body is a major contributor to high intraocular pressure (IOP). Topical or systemic glucocorticoid use may increase the prevalence.

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 27 Sep 2026 06:00:00 EST

(Sun, 27 Sep 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 27 Sep 2026 07:00:00 EST

(Sun, 27 Sep 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Jason T, Pituitary Bio

Sun, 27 Sep 2026 09:00:00 EST

(Sun, 27 Sep 2026 )

Jason is from England. Pituitary tumour found in 2020(posterior lobe),now test after test and 2nd MRI still shows microadenoma. He also had two traumatic brain injuries.

What Is The Life Expectancy Of Someone With Cushing's Syndrome?

Sun, 27 Sep 2026 09:00:00 EST

(Sun, 27 Sep 2026 )

Complications of Cushing's syndrome include Hypertension, DM, infection, Bone fracture, mood swings, memory loss. If left untreated then life expectancy would be around 5 years.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 27 Sep 2026 10:00:00 EST

(Sun, 27 Sep 2026 )

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 27 Sep 2026 11:00:00 EST

(Sun, 27 Sep 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Paraneoplastic Cushing Syndrome Unmasking Small Cell Lung Cancer: A Rare Presentation

Sun, 27 Sep 2026 15:00:00 EST

(Sun, 27 Sep 2026 )

We present a case of a middle-aged woman who presented with chest pain and shortness of breath. Laboratory tests revealed persistent hypokalaemia, hyperglycaemia, and metabolic alkalosis despite treatment. Imaging identified a mass near the right hilum suggestive of lung malignancy. Endocrine evaluation showed markedly elevated cortisol and adrenocorticotropic hormone levels, consistent with paraneoplastic Cushing syndrome caused by ectopic hormone production.

https://cushings.invisionzone.com/topic/57869-paraneoplastic-cushing-syndrome-unmasking-small-cell-lung-cancer-a-rare-presentation/

A Challenging Case of Severe Cushing’s Syndrome in the Course of Metastatic Thymic Neuroendocrine Carcinoma with a Synchronous Adrenal Tumor

Sun, 27 Sep 2026 17:00:00 EST

(Sun, 27 Sep 2026 )

Endogenous Cushing’s syndrome (CS) is a rare endocrine condition caused by excess cortisol production with an annual incidence of 0.2–5 cases per million people

Media Attention! Cushing's on Today

Mon, 28 Sep 2026 02:00:00 EST

(Mon, 28 Sep 2026 )

Blood tests and an MRI finally confirmed the doctor’s suspicion: Yawn had a tumor in her pituitary gland — a pea-size organ at the base of the brain — that was causing the gland to release too much adrenocorticotropic hormone. That, in turn, flooded her body with cortisol, a steroid hormone that’s normally released in response to stress or danger. The resulting condition is called Cushing disease.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Mon, 28 Sep 2026 03:00:00 EST

(Mon, 28 Sep 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Disease Remission and Surgical Outcomes of Endoscopic Transsphenoidal Surgery for Cushing Disease: A Single Center Experience

Mon, 28 Sep 2026 04:00:00 EST

(Mon, 28 Sep 2026 )

Transsphenoidal surgery is the primary treatment for patients with Cushing disease (CD). This study assessed the surgical and endocrinologic outcomes of patients with CD following endoscopic pituitary surgery using strict biochemical criteria to guide surveillance in patients not achieving early remission.

https://cushings.invisionzone.com/topic/57943-disease-remission-and-surgical-outcomes-of-endoscopic-transsphenoidal-surgery-for-cushing-disease-a-single-center-experience/

Dee (Dee), Pituitary Bio

Mon, 28 Sep 2026 05:00:00 EST

(Mon, 28 Sep 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Mon, 28 Sep 2026 06:00:00 EST

(Mon, 28 Sep 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Sterotherapeutics begins Phase II trial for ST-002 targeting Cushing’s Syndrome

Mon, 28 Sep 2026 06:00:00 EST

(Mon, 28 Sep 2026 )

The trial will assess the drug's efficacy, tolerability, and safety in individuals with Cushing's.

https://cushings.invisionzone.com/topic/57785-sterotherapeutics-begins-phase-ii-trial-for-st-002-targeting-cushing%E2%80%99s-syndrome/

📰 Clinical and Surgical Outcomes of Pediatric Cushing’s Disease Following Endoscopic Transsphenoidal Surgery

Mon, 28 Sep 2026 06:00:00 EST

(Mon, 28 Sep 2026 )

Cushing’s disease (CD) is characterized by hypercortisolism due to excessive adrenocorticotropic hormone (ACTH) secretion from a pituitary adenoma. Though more common in adults, pediatric cases constitute approximately 5% of those seen in adults. Early diagnosis and treatment are critical due to the severe impacts on growth and development in children. Endoscopic transsphenoidal surgery (ETSS) is the preferred first-line treatment for both children and adults.

https://cushings.invisionzone.com/topic/57801-clinical-and-surgical-outcomes-of-pediatric-cushing%E2%80%99s-disease-following-endoscopic-transsphenoidal-surgery/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Mon, 28 Sep 2026 07:00:00 EST

(Mon, 28 Sep 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Mon, 28 Sep 2026 08:00:00 EST

(Mon, 28 Sep 2026 )

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult. My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

In Memory: Joanne Swain

Mon, 28 Sep 2026 10:00:00 EST

(Mon, 28 Sep 2026 )

Joanne was known on the boards as raggettyjoanne.

Mario VandDermeij announced the passing of his loving wife of 23 years. Joanne Swain VanDermeij at the age of 56.

After 2 years and 3 months of fighting the system, Joanne was finally diagnosed March the 14th, 2011, with full blown adrenal Cushing's.

http://cushings.invisionzone.com/profile/10929-raggettyjoanne/

In Memory: Bettye Jean Douglas

Mon, 28 Sep 2026 10:00:00 EST

(Mon, 28 Sep 2026 )

Bettye passed away due to complications of Cushing’s disease. Once she was finally diagnosed, a decision was made against surgery and Bettye was put on the cortisol-lowering medication Korlym. Though she had initially gained weight from Cushing’s disease, as many patients do, she rapidly lost weight and was admitted into hospice care soon after.

Basics: Meds: Recorlev

Mon, 28 Sep 2026 10:00:00 EST

(Mon, 28 Sep 2026 )

Cushing’s disease is a progressive pituitary disorder in which there is an excess of cortisol in the body. While the disease can be treated surgically, this option is not possible for all patients. This is one of the approved medications that assist in controlling cortisol levels in people with Cushing’s disease.

Recorlev was approved by the FDA in December 2021 to treat those Cushing’s patients for whom surgery is not a choice or has failed to lower cortisol levels.

Emergence of De Novo Conditions Following Remission of Cushing Syndrome: A Case Report and Scoping Review

Mon, 28 Sep 2026 10:00:00 EST

(Mon, 28 Sep 2026 )

Our scoping review identified several cases of de novo conditions emerging following the remission of Cushing syndrome. They occurred mostly in women and within the year following remission.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Mon, 28 Sep 2026 10:00:00 EST

(Mon, 28 Sep 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Changing face of Cushing’s Disease Over Three Decades in Pituitary Center

Mon, 28 Sep 2026 10:00:00 EST

(Mon, 28 Sep 2026 )

As the clinical presentation of Cushing’s disease changes over time, waiting for the typical Cushing’s clinic can delay diagnosis. It is important that clinicians take this into account when they suspect CD.

https://cushings.invisionzone.com/topic/57886-changing-face-of-cushing%E2%80%99s-disease-over-three-decades-in-pituitary-center/

Sparrow Pharmaceuticals Announces Completion of Phase 2 Trial and FDA Orphan Drug Designation of Clofutriben for Endogenous Cushing’s Syndrome

Mon, 28 Sep 2026 11:00:00 EST

(Mon, 28 Sep 2026 )

HSD-1 inhibition with clofutriben is a completely novel approach to the treatment of endogenous Cushing’s syndrome that may overcome many of the serious problems with current therapies, including major safety, tolerability, and complexity issues such as the risk of adrenal insufficiency and adrenal crisis.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Mon, 28 Sep 2026 11:00:00 EST

(Mon, 28 Sep 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Cardiometabolic Complications After Cushing’s Disease Remission

Mon, 28 Sep 2026 11:00:00 EST

(Mon, 28 Sep 2026 )

Cushing’s disease (CD) is associated with phenotypic traits and comorbidities that may persist after the normalization of cortisol levels. Medical therapy is usually given in recurrent or persistent CD after transsphenoidal surgery. We aimed to investigate the impact of long-term normalization of daily cortisol secretion on clinical picture and cardiometabolic comorbidities, comparing surgical remission to medical treatment.

https://cushings.invisionzone.com/topic/57817-cardiometabolic-complications-after-cushing%E2%80%99s-disease-remission/

Cancer risk elevated for adults after Cushing’s syndrome diagnosis

Mon, 28 Sep 2026 14:00:00 EST

(Mon, 28 Sep 2026 )

I certainly know this to be true I'm an 18 year survivor of yet another disease that I shouldn't have gotten: kidney cancer.

https://cushings.invisionzone.com/topic/57758-cancer-risk-elevated-for-adults-after-cushing%E2%80%99s-syndrome-diagnosis/

Trish, Steroid-Induced Bio

Mon, 28 Sep 2026 17:00:00 EST

(Mon, 28 Sep 2026 )

She got Cushing’s Syndrome from abundant steroid injections due to a severe back injury and it has rendered her “comatose”. She has no energy, she sleeps all the time, and I miss her and am lonely when she is in this state, which is all the time.

https://cushingsbios.com/2025/11/28/trish-steroid-induced-bio/

Add or update Your Bio

Tue, 29 Sep 2026 01:00:00 EST

(Tue, 29 Sep 2026 )

Please add your bio. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2024/10/28/we-have-a-new-bio-form/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Tue, 29 Sep 2026 03:00:00 EST

(Tue, 29 Sep 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Crinetics Pharma’s Promising Study on CRN04894 for Cushing’s Syndrome: A Potential Game-Changer?

Tue, 29 Sep 2026 03:00:00 EST

(Tue, 29 Sep 2026 )

Crinetics Pharmaceuticals is conducting a study titled ‘A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing’s Syndrome.’ This study aims to evaluate the safety, tolerability, and pharmacokinetics of CRN04894, an ACTH receptor antagonist, in treating Cushing’s Syndrome, a condition characterized by excessive cortisol production. The study’s significance lies in its potential to offer a new treatment avenue for patients with Cushing’s disease or Ectopic ACTH Syndrome.

https://cushings.invisionzone.com/topic/57905-crinetics-pharma%E2%80%99s-promising-study-on-crn04894-for-cushing%E2%80%99s-syndrome-a-potential-game-changer/

Cushing's Syndrome in Pregnancy in Which Laparoscopic Adrenalectomy was Safely Performed by a Retroperitoneal Approach

Tue, 29 Sep 2026 04:00:00 EST

(Tue, 29 Sep 2026 )

Laparoscopic adrenalectomy is the standard treatment for adrenal tumors caused by Cushing's syndrome. However, few pregnant women have undergone adrenalectomy because of the risk of general anesthesia and surgery.

Delayed Diagnosis of Ectopic Cushing Syndrome

Tue, 29 Sep 2026 04:00:00 EST

(Tue, 29 Sep 2026 )

While many patients with Cushing syndrome have a delayed diagnosis, this case highlights the critical need to increase awareness of the signs and symptoms of hypercortisolism and to improve the understanding of appropriate screening tests among nonendocrine providers.

Dee (Dee), Pituitary Bio

Tue, 29 Sep 2026 05:00:00 EST

(Tue, 29 Sep 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Tue, 29 Sep 2026 06:00:00 EST

(Tue, 29 Sep 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Tue, 29 Sep 2026 07:00:00 EST

(Tue, 29 Sep 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

A Second Look at Cushing Disease: Hypercortisolism Recurrence From Another Gland

Tue, 29 Sep 2026 07:00:00 EST

(Tue, 29 Sep 2026 )

Cushing disease (CD) is the most common form of adrenocorticotropin (ACTH)-dependent Cushing syndrome (CS), whereas unilateral adrenal adenoma is the most common cause of ACTH-independent CS. However, the occurrence of different subtypes of CS in a single individual is very rare.

https://cushings.invisionzone.com/topic/57836-a-second-look-at-cushing-disease-hypercortisolism-recurrence-from-another-gland/

Basics: Testing: Dex Tests

Tue, 29 Sep 2026 08:00:00 EST

(Tue, 29 Sep 2026 )

Dexamethasone suppression test measures whether adrenocorticotrophic hormone (ACTH) secretion by the pituitary can be suppressed.

How the Test is Performed

During this test, you will receive dexamethasone. This is a strong man-made (synthetic) glucocorticoid medicine. Afterward, your blood is drawn so that the cortisol level in your blood can be measured.

Cushing's: A comprehensive guide to understanding a devastating condition

Tue, 29 Sep 2026 09:00:00 EST

(Tue, 29 Sep 2026 )

By Dr. Lewis Blevins: This book is perhaps something a little different than most would expect. Firstly, it's a single-author book on Cushing's syndrome. It is not, like most textbooks, a compendium of edited submissions from multiple authors where there are often divergent opinions from one chapter to the next. Instead, it's a treatise reflecting my education and experience. It is not referenced but instead each chapter is followed by suggested readings. It represents my thoughts, understanding and a personal reflection on a career of evaluating a multitude of patients suspected of having the disorder and treating those confirmed to have hypercortisolism due to one cause or another. It reflects my perspectives of the art and science of the field.

More info at https://cushings.invisionzone.com/topic/57752-cushings-a-comprehensive-guide-to-understanding-a-devastating-condition/

Seliciclib for the Treatment of Cushing’s Disease Targeting Pituitary

Tue, 29 Sep 2026 10:00:00 EST

(Tue, 29 Sep 2026 )

Seliciclib (R-roscovitine) has been shown in preclinical studies to inhibit neoplastic corticotroph proliferation and the production of adrenocorticotropic hormone (ACTH) in the pituitary gland. Therefore, for a study, researchers sought to investigate the effectiveness of seliciclib as a pituitary-targeting treatment for patients with Cushing’s disease (CD).

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Tue, 29 Sep 2026 10:00:00 EST

(Tue, 29 Sep 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Unveiling the Uncommon: Cushing’s Syndrome (CS) Masquerading as Severe Hypokalemia

Tue, 29 Sep 2026 11:00:00 EST

(Tue, 29 Sep 2026 )

A 48-year-old male with a history of hypertension presented to his primary care physician with complaints of bilateral leg swelling, occasional shortness of breath, dizziness, and a general feeling of malaise persisting for 10 days. The patient reported increased water intake and urinary frequency without dysuria. The patient was diagnosed with hypertension eight months ago. He experienced progressive muscle weakness over two months, hindering his ability to perform daily activities, including using the bathroom.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Tue, 29 Sep 2026 11:00:00 EST

(Tue, 29 Sep 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Double Synchronous Functional Pituitary Adenomas Causing Acromegaly and Subclinical Cushing Disease.

Tue, 29 Sep 2026 16:00:00 EST

(Tue, 29 Sep 2026 )

We report the case of a patient with double functional pituitary adenomas causing acromegaly and subclinical Cushing's disease. A 45-year-old woman was referred to our Department for suspected acromegaly. Her past medical history included diabetes mellitus treated with oral antidiabetic drugs and hypertension.

https://cushings.invisionzone.com/topic/57847-double-synchronous-functional-pituitary-adenomas-causing-acromegaly-and-subclinical-cushing-disease/

The Effect of Hypercortisolism Treatment on Dyslipidemia in Cushing Syndrome

Tue, 29 Sep 2026 17:00:00 EST

(Tue, 29 Sep 2026 )

Our study demonstrate a significant improvement in serum lipid levels after treatment of Cushings Syndrome. Since the cardiovascular complications of hypercortisolism depend on several factors, further studies are needed to determine whether this directly translates into an adequate reduction in the risk of major cardiovascular events.

https://cushings.invisionzone.com/topic/57931-the-effect-of-hypercortisolism-treatment-on-dyslipidemia-in-cushing-syndrome/

Laura, In The Media

Tue, 29 Sep 2026 18:00:00 EST

(Tue, 29 Sep 2026 )

Cushing's has appeared several times in the media. Jayne Kerns encouraged Zastrow to check out a Cushing's Web site, which Zastrow did. Every symptom listed matched her condition. Her doctor ran some tests, and the results confirmed Zastrow had Cushing's, a hormonal disorder often brought on by a tumor.

https://cushingsbios.com/2025/11/29/laura-in-the-media/

Birthday of the Message Boards

Wed, 30 Sep 2026 01:00:00 EST

(Wed, 30 Sep 2026 )

Today is the birthday, or anniversary, of the boards starting September 30, 2000

(The rest of the site started earlier that year on July 21, 2000)

As of today, we have 73,024 members who have made countless posts.

Find the message boards here: http://cushings.invisionzone.com/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Wed, 30 Sep 2026 03:00:00 EST

(Wed, 30 Sep 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dee (Dee), Pituitary Bio

Wed, 30 Sep 2026 05:00:00 EST

(Wed, 30 Sep 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Wed, 30 Sep 2026 06:00:00 EST

(Wed, 30 Sep 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

❣️The Message Boards Turn 25 Today! ❣️

Wed, 30 Sep 2026 06:00:00 EST

(Wed, 30 Sep 2026 )

Today is the birthday, or anniversary, of the boards starting September 30, 2000 (The rest of the site started earlier that year on July 21, 2000)

As of today, we have 73,357 members who have made countless posts.

Find the Message Boards at https://cushings.invisionzone.com/

Testing Vitamin B3

Wed, 30 Sep 2026 07:00:00 EST

(Wed, 30 Sep 2026 )

Since I just had Mohs surgery for squamous cell carcinoma, I immediately went to amazon to search for nicotinamide.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Wed, 30 Sep 2026 07:00:00 EST

(Wed, 30 Sep 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Home cortisol tests: 3 of the best

Wed, 30 Sep 2026 09:00:00 EST

(Wed, 30 Sep 2026 )

There are several home cortisol tests available to purchase over the counter or online. These allow a person to take a sample of blood, urine, or saliva before sending it off for analysis.

After taking a home cortisol test, people can usually receive their results within 2–5 days online or via a telephone call with a healthcare professional.

However, there are currently no studies investigating the reliability of these home cortisol tests. Therefore, people should follow up on their test results with a healthcare professional.

Treatments: Adrenalectomy and BLA (Bilateral adrenalectomy)

Wed, 30 Sep 2026 09:00:00 EST

(Wed, 30 Sep 2026 )

Some pain is normal after any surgery. Different people have different levels of sensitivity to pain. In general, you should experience a little less pain every day. Pain is usually worse in the evening when you are trying to go to sleep. Do not be afraid to take the pain medicine prescribed for you, particularly before you go to sleep, but you can stop taking it if you are comfortable. Most pain medications cause constipation and they can also cause drowsiness. Do not drive or operate power tools after you take narcotic pain medications. If you have only mild discomfort, try taking extra-strength Tylenol® as directed.

https://cushings-help.com/2024/10/30/adrenalectomy-and-bla/

Cushing Syndrome in Paediatric Population

Wed, 30 Sep 2026 09:00:00 EST

(Wed, 30 Sep 2026 )

The diagnosis of Cushing's Syndrome is often difficult due to the insidious onset of hypercortisolism, in absence of relevant early signs of the disease, as well as the rarity of the disease in childhood. For these reasons, the time to diagnosis has been reported as a mean of 33 months (95% CI 29–38) and not dissimilar to adult population.

https://cushings.invisionzone.com/topic/57762-cushing-syndrome-in-paediatric-population/

A Second Look at Refractory Edema: Delayed Diagnosis of Paraneoplastic Cushing’s Syndrome in Small Cell Lung Cancer

Wed, 30 Sep 2026 09:00:00 EST

(Wed, 30 Sep 2026 )

Paraneoplastic Cushing syndrome (PCS) is a rare manifestation of ectopic adrenocorticotropic hormone (ACTH) production, mostly associated with bronchial carcinoid and small cell lung cancer (SCLC).

https://cushings.invisionzone.com/topic/57932-a-second-look-at-refractory-edema-delayed-diagnosis-of-paraneoplastic-cushing%E2%80%99s-syndrome-in-small-cell-lung-cancer/

Video: Morning Medical Update - Cushing's Disease

Wed, 30 Sep 2026 09:00:00 EST

(Wed, 30 Sep 2026 )

Cushing's Disease can be treated, but only with the right doctor and diagnosis.

We explore the barriers that make some patients endure years of symptoms before finding relief.

https://cushings.invisionzone.com/topic/57933-morning-medical-update-cushings-disease/

Environmental Issues and Cushing’s

Wed, 30 Sep 2026 09:00:00 EST

(Wed, 30 Sep 2026 )

Scientists now tell us there is something in our waters that we least expected.

That “something” is a class of chemicals called endocrine disruptors, and Dr. Vicki Blazer, a fisheries biologist at the United States Geological Survey, thinks the chemicals are responsible for the high concentrations of intersex fish found in the Potomac, and other rivers in the mid-Atlantic.

https://cushieblog.com/2025/12/30/environmental-issues-and-cushings/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Wed, 30 Sep 2026 10:00:00 EST

(Wed, 30 Sep 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Cushing’s Syndrome Masquerading as Fibromyalgia: A Case Series

Wed, 30 Sep 2026 11:00:00 EST

(Wed, 30 Sep 2026 )

Three young female patients with a history of generalized body pain were diagnosed with fibromyalgia. They visited several specialities which related patients' symptoms to their previous diagnosis of fibromyalgia and were treated symptomatically. These patients developed a multitude of clinical features including fractures, hypertension, abnormal weight gain, proximal myopathic pain and bruising. They were seen by rheumatologists whose assessment was that their clinical features were not entirely due to fibromyalgia and suspected that patients have a possible underlying endocrine cause. Patients were referred to an endocrinologist for further tests with suspicion of Cushing’s syndrome. Laboratory tests and imaging confirmed a diagnosis of Cushing’s syndrome. Two of them had adrenal adenoma and one had iatrogenic corticosteroid use. These cases emphasize the need for thorough clinical evaluation for patients who are thought to have fibromyalgia. Fibromyalgia is a diagnosis of exclusion.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Wed, 30 Sep 2026 11:00:00 EST

(Wed, 30 Sep 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Shannon, Pituitary Bio

Wed, 30 Sep 2026 15:00:00 EST

(Wed, 30 Sep 2026 )

In the past year alone I’ve seen 5 doctors who couldn’t tell me the time. They made me feel like I was crazy. Even when I got double vision in my right eye and had to wear an eye patch for 3 months. No one could figure out why. I still have vision disturbances but after two med packs of steriods the double vision went away.

https://cushingsbios.com/2025/09/30/shannon-pituitary-bio/

Adrenal Cushing’s Syndrome in Pregnancy Complicated by Fetal Growth Restriction Following Retroperitoneoscopic Adrenalectomy

Wed, 30 Sep 2026 16:00:00 EST

(Wed, 30 Sep 2026 )

A 29-year-old Japanese pregnant woman, G5P3A1, conceived spontaneously and was referred to our hospital because of uncontrolled hypertension at 24 weeks of gestation. On admission, she presented with physical findings characteristic of Cushing's syndrome (CS), such as moon face, buffalo hump, and reddish-purple striae. Laboratory examination revealed hyperglycemia and hypercortisolism with suppressed adrenocorticotropic hormone levels. Imaging studies revealed a right adrenocortical adenoma, and the patient was clinically diagnosed with adrenal CS.

https://cushings.invisionzone.com/topic/57924-adrenal-cushing%E2%80%99s-syndrome-in-pregnancy-complicated-by-fetal-growth-restriction-following-retroperitoneoscopic-adrenalectomy/

Comment - ❣️The Message Boards Turn 22 Today! ❣️

Wed, 30 Sep 2026 17:00:00 EST

(Wed, 30 Sep 2026 )

Comment from LinkedIn:

Congratulations Mary! You have helped more lives than you will ever know including mine. I am forever grateful for finding your website 18 years ago when I was finally diagnosed with Cushings Disease after a 2-year search for answers. Thank you ?

Clinical Features, Diagnosis and Treatment Outcomes of Cushing's Disease In Children: a Multicenter Study

Wed, 30 Sep 2026 17:00:00 EST

(Wed, 30 Sep 2026 )

Herein, national data of the clinical experience on paediatric CD have been presented. Our findings highlight that presenting complaints may be subtle in children, the sensitivities of the diagnostic tests are very variable and require a careful interpretation, and MRI fails to detect adenoma in approximately one-third of cases. Finally, clinicians should be aware of the recurrence of the disease during the follow-up after surgery.

Reconstructive Liposuction for Residual Lipodystrophy After Remission of Cushing’s Disease

Wed, 30 Sep 2026 18:00:00 EST

(Wed, 30 Sep 2026 )

We report a case of a 16-year-old female with recurrent Cushing’s disease secondary to a pituitary microadenoma, confirmed by elevated urinary free cortisol and magnetic resonance imaging (MRI). It was initially treated with transsphenoidal resection in 2019; disease recurrence was confirmed and again treated in 2024.

https://cushings.invisionzone.com/topic/57848-reconstructive-liposuction-for-residual-lipodystrophy-after-remission-of-cushing%E2%80%99s-disease/

Voices from the Past: Laura F, Undiagnosed Bio

Wed, 30 Sep 2026 18:00:00 EST

(Wed, 30 Sep 2026 )

I’ve been gaining weight for about 3 1/2 yrs since having my thyroid removed due to a 25 yr old nodule that was calcified. My thyroid levels have always been good, before and after removal. There were A typical cells in the nodule, that’s why they advised removing the thyroid.

As I gain weight and have lumps of inflammation now over all of my body, all I have been told is to eat less and exercise more. Even though I have told my drs that I barely eat at all.

https://cushingsbios.com/2025/11/30/laura-f-undiagnosed-bio/

Cushing’s, Cancer and Other Serious Diseases

Wed, 30 Sep 2026 18:00:00 EST

(Wed, 30 Sep 2026 )

I was drawn to this blog post because the author mentioned that she had both Cushing’s and cancer, a kind of unusual combination.

1974 to Today: Seal it up
By Experience
I still haven’t heard what the consensus is on my aftercare: Cushing’s and Cancer. I don’t know what I will be expecting to feel like after surgery. My endocrinologist said that I should get sick after the surgery and need some kind of …
1974 to Today – http://1974totoday.blogspot.com/

Investigational Cushing’s Syndrome Medication Reduces BP, Glucose in Open-Label Trial

Thu, 01 Oct 2026 03:00:00 EST

(Thu, 01 Oct 2026 )

Relacorilant was deemed well tolerated in the trial. The most common adverse events were nausea, edema, back and extremity pain and fatigue, all of which were mild or moderate in nature and are consistent with symptoms people experience after surgery or the start of therapy to treat hypercortisolism.

Ectopic ACTH-secreting Pheochromocytoma Without Typical Signs of Cushing Syndrome

Thu, 01 Oct 2026 03:00:00 EST

(Thu, 01 Oct 2026 )

Abstract

This case report describes a 42-year-old female with a rare pheochromocytoma presenting without classic Cushingoid features but with uncontrolled hypertension, type 2 diabetes, and recurrent headaches. Despite the absence of typical signs, biochemical analysis revealed elevated cortisol and ACTH levels, and imaging showed a 6 cm adrenal mass. The patient was stabilized preoperatively with alpha-blockers and metyrapone before undergoing a successful laparoscopic adrenalectomy. Histopathology confirmed pheochromocytoma with aggressive features. Postoperatively, her blood pressure and symptoms improved, and her cortisol levels normalized. This case underscores the diagnostic challenges of ACTH-secreting pheochromocytomas without classic hypercortisolism signs and emphasizes the need for thorough endocrine and imaging assessments. Surgical resection remains the definitive treatment, with long-term follow-up essential to monitor for recurrence. This case contributes to the limited literature on the coexistence of pheochromocytoma and ectopic ACTH secretion.

https://cushings.invisionzone.com/topic/57818-ectopic-acth-secreting-pheochromocytoma-without-typical-signs-of-cushing-syndrome/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Thu, 01 Oct 2026 03:00:00 EST

(Thu, 01 Oct 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Liver impairment and medical management of Cushing Syndrome and MACSProvisionally

Thu, 01 Oct 2026 03:00:00 EST

(Thu, 01 Oct 2026 )

Cushing syndrome (CS) and Mild Autonomous Cortisol Secretion syndrome (MACS) are states of endogenous hypercortisolemia, associated with multiple metabolic complications.

https://cushings.invisionzone.com/topic/57887-liver-impairment-and-medical-management-of-cushing-syndrome-and-macs-provisionally/

Global Longitudinal Strain Reduction With Apical Sparing in Cushing Syndrome-Related Heart Failure With Preserved Ejection Fraction (HFpEF)

Thu, 01 Oct 2026 03:00:00 EST

(Thu, 01 Oct 2026 )

We describe a case of a 56-year-old woman with a history of recurrent pituitary adenoma, not well followed, and known comorbidities of coronary artery disease, hypertension, and type 2 diabetes mellitus. She arrived with severely high blood pressure and signs pointing to hypercortisolism. Further evaluation revealed left ventricular hypertrophy, reduced global longitudinal strain, and preserved left ventricular ejection fraction, consistent with heart failure with preserved ejection fraction (HFpEF). Workup for amyloidosis was negative.

This case highlights that chronic hypercortisolism may cause pathophysiological changes in the heart, leading to HFpEF, and may induce myocardial fibrosis and impaired myocardial mechanics, producing an echocardiographic pattern that can mimic infiltrative cardiomyopathy. Recognition of this overlap is crucial to avoid misdiagnosis and to ensure timely endocrine and cardiovascular management.

https://cushings.invisionzone.com/topic/57888-global-longitudinal-strain-reduction-with-apical-sparing-in-cushing-syndrome-related-heart-failure-with-preserved-ejection-fraction-hfpef/

Basics: What Causes Abnormal Cortisol Levels?

Thu, 01 Oct 2026 04:00:00 EST

(Thu, 01 Oct 2026 )

“In general, cortisol levels tend to peak in the late morning and gradually decline throughout the day,” he explains. “When a stressful event occurs, the increased cortisol will work alongside our ‘fight or flight’ mechanisms to either upregulate or downregulate bodily functions. [Affected systems include] the central nervous system, cardiovascular system, gastrointestinal system, or immune system.”

Dee (Dee), Pituitary Bio

Thu, 01 Oct 2026 05:00:00 EST

(Thu, 01 Oct 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Thu, 01 Oct 2026 06:00:00 EST

(Thu, 01 Oct 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Sleep Impairment Similar in Cushing Syndrome, Mild Autonomous Cortisol Secretion

Thu, 01 Oct 2026 06:00:00 EST

(Thu, 01 Oct 2026 )

Patients with Cushing syndrome and mild autonomous cortisol secretion experienced similar degrees of sleep impairment.

https://cushings.invisionzone.com/topic/57907-sleep-impairment-similar-in-cushing-syndrome-mild-autonomous-cortisol-secretion/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Thu, 01 Oct 2026 07:00:00 EST

(Thu, 01 Oct 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

“The Healthcare System Did Fail Me Repeatedly”: a Qualitative Study On Experiences Of Healthcare Among Canadian Women With Cushing’s Syndrome

Thu, 01 Oct 2026 07:00:00 EST

(Thu, 01 Oct 2026 )

As a rare endocrine disorder, Cushing’s Syndrome (Cushing’s) is characterized by numerous symptoms and a non-specific presentation, leading to a delay to diagnosis for patients with this disease. To date, research examining the lived experiences of patients with Cushing’s in healthcare is absent in the literature. This preliminary inquiry into the healthcare experiences of women with Cushing’s aimed to examine the utility of this line of inquiry to support the patient centered care of individuals with Cushing’s.

https://cushings.invisionzone.com/topic/57759-%E2%80%9Cthe-healthcare-system-did-fail-me-repeatedly%E2%80%9D-a-qualitative-study-on-experiences-of-healthcare-among-canadian-women-with-cushing%E2%80%99s-syndrome/

Comment added to Day 1: Cushing's Awareness Challenge 2024

Thu, 01 Oct 2026 08:00:00 EST

(Thu, 01 Oct 2026 )

While American actress Amy Schumer is spreading the word about Cushing’s in general, I think that in some ways she is hurting things for everyone else. CBS News reports that “she says she now feels ‘reborn’ after her diagnosis, and while some forms of Cushing can be fatal, she has a type that ‘will just work itself out.’”

How many others will try to get diagnosed and only be told not to worry, that it “will just work itself out”?

The STUB1-TPIT Axis Regulates the Secretion of Adrenocorticotrophic Hormone in Cushing Disease

Thu, 01 Oct 2026 09:00:00 EST

(Thu, 01 Oct 2026 )

Cushing’s disease (CD) is a clinical syndrome caused by excessive secretion of adrenocorticotropic hormone (ACTH) from a pituitary corticotroph adenoma, resulting in adrenal cortical hyperplasia and overproduction of cortisol. The T-box transcription factor (TPIT) is crucial for regulating ACTH secretion in pituitary corticotroph adenomas. This study aims to explore the ubiquitin-mediated degradation of TPIT and identify potential pharmaceutical agents for treating CD.

https://cushings.invisionzone.com/topic/57874-the-stub1-tpit-axis-regulates-the-secretion-of-adrenocorticotrophic-hormone-in-cushing-disease/

Adults with Cushing’s Syndrome Report High Burden Of Illness, Despite Ongoing Treatment

Thu, 01 Oct 2026 10:00:00 EST

(Thu, 01 Oct 2026 )

Key takeaways:

Cushing’s syndrome symptoms moderately impact quality of life for adults with the condition.
Weight gain, muscle fatigue and menstrual changes decline in severity from diagnosis to follow-up.

Adrenocorticotropic Hormone-Dependent Cushing's Syndrome Complicated With Gastric Ulcer Perforation in a 30-Year-Old Saudi Female

Thu, 01 Oct 2026 10:00:00 EST

(Thu, 01 Oct 2026 )

We report a case of a recently diagnosed adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome in a 30-years-old female who presented initially with a three-month history of progressive weight gain, generalized weakness, acne, menstrual irregularity, and severe hypokalemia, and then developed a gastric ulcer perforation only one month after her ACTH-dependent Cushing's syndrome diagnosis and was managed through emergent surgery.

Cardiac Magnetic Resonance Reveals Biventricular Impairment In Cushing’s Syndrome

Thu, 01 Oct 2026 10:00:00 EST

(Thu, 01 Oct 2026 )

Cushing’s syndrome (CS) is associated with severe cardiovascular (CV) morbidity and mortality. Cardiac magnetic resonance (CMR) is the non-invasive gold standard for assessing cardiac structure and function; however, few CMR studies explore cardiac remodeling in patients exposed to chronic glucocorticoid (GC) excess. We aimed to describe the CMR features directly attributable to previous GC exposure in patients with cured or treated endogenous CS.

Impact of Remission Status in Endogenous Cushing's Syndrome on Cancer Incidence

Thu, 01 Oct 2026 10:00:00 EST

(Thu, 01 Oct 2026 )

Endogenous Cushing's syndrome (CS) has been linked with an increased risk of cancer. We aimed to evaluate the association between cancer risk and disease remission post-surgery in adrenal CS and Cushing's disease (CD).

https://cushings.invisionzone.com/topic/57786-impact-of-remission-status-in-endogenous-cushings-syndrome-on-cancer-incidence/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Thu, 01 Oct 2026 10:00:00 EST

(Thu, 01 Oct 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

A Silent Invader: Asymptomatic Rhodococcus Infection Unmasked In a Patient With Ectopic ACTH-Dependent Cushing’s Syndrome

Thu, 01 Oct 2026 10:00:00 EST

(Thu, 01 Oct 2026 )

We report the case of a 29-year-old male who presented with new-onset diabetes mellitus, resistant hypertension and significant weight gain. Physical examination revealed features consistent with Cushing’s syndrome.

https://cushings.invisionzone.com/topic/57889-a-silent-invader-asymptomatic-rhodococcus-infection-unmasked-in-a-patient-with-ectopic-acth-dependent-cushing%E2%80%99s-syndrome/

Pituitary Surgery Outcome in Patients 75 Years and Older

Thu, 01 Oct 2026 11:00:00 EST

(Thu, 01 Oct 2026 )

Surgery beyond the age of 75, mainly relying on an endoscopic endonasal transsellar approach, is effective and safe, provided that patients are managed in tertiary centers.

Corcept’s relacorilant GRADIENT trial misses primary endpoint

Thu, 01 Oct 2026 11:00:00 EST

(Thu, 01 Oct 2026 )

The Phase III GRADIENT trial for relacorilant has missed its primary endpoint of improving SBP for Cushing's syndrome patients.

https://cushings.invisionzone.com/topic/57763-corcept%E2%80%99s-relacorilant-gradient-trial-misses-primary-endpoint/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Thu, 01 Oct 2026 11:00:00 EST

(Thu, 01 Oct 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

How is Cushing's Disease Diagnosed?

Thu, 01 Oct 2026 11:00:00 EST

(Thu, 01 Oct 2026 )

Diagnosing Cushing's disease involves a series of tests to confirm excessive cortisol production and determine its source.

https://cushings.invisionzone.com/topic/57787-how-is-cushings-disease-diagnosed/

What Do You Think? Alternate Treatments

Thu, 01 Oct 2026 17:00:00 EST

(Thu, 01 Oct 2026 )

Has your doctor ever tried to dissuade you from using an alternative treatment?

In Memory of Lenise Petersen

Fri, 02 Oct 2026 01:00:00 EST

(Fri, 02 Oct 2026 )

Lenise passed away Wednesday, Oct. 2, 2002 at 23 years old, just after her surgery.

PET/MRI may improve diagnosis of Cushing disease

Fri, 02 Oct 2026 02:00:00 EST

(Fri, 02 Oct 2026 )

In patients diagnosed with the disease yet who had inconclusive MRI results, PET/MRI was positive in 100% of cases, noted lead author Ilanah Pruis, a doctoral student at Erasmus University Medical Center in Rotterdam, Netherlands.

“This multimodal imaging technique provides a welcome improvement for diagnosis, planning of surgery, and clinical outcome in patients with Cushing disease,” the authors wrote.

Myocardial Work Impairment in Patients With Cushing’s Syndrome

Fri, 02 Oct 2026 03:00:00 EST

(Fri, 02 Oct 2026 )

Endogenous Cushing’s Syndrome (CS) is associated with an increased cardiovascular (CV) and metabolic risk profile, yet the specific impact of hypercortisolism on myocardial function remains inadequately understood.

https://cushings.invisionzone.com/topic/57805-myocardial-work-impairment-in-patients-with-cushing%E2%80%99s-syndrome/

Ivory Tower: New PET Scan Molecule Offers Breakthrough in Detecting Cushing’s Syndrome

Fri, 02 Oct 2026 03:00:00 EST

(Fri, 02 Oct 2026 )

Researchers from endocrinology and nuclear medicine departments have introduced a new PET scan molecule that enhances the detection of adenoma/small tumour causing Cushing’s syndrome. This development promises to improve surgical interventions and patient outcomes.

https://cushings.invisionzone.com/topic/57806-ivory-tower-new-pet-scan-molecule-offers-breakthrough-in-detecting-cushing%E2%80%99s-syndrome/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Fri, 02 Oct 2026 03:00:00 EST

(Fri, 02 Oct 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Preop TT3 Predicts HPA Axis Recovery After Cushing Surgery

Fri, 02 Oct 2026 04:00:00 EST

(Fri, 02 Oct 2026 )

Patients with Cushing’s disease (CD) experienced transient central adrenal insufficiency (CAI) after successful surgery. However, the reported recovery time of hypothalamic-pituitary-adrenal (HPA) axis varied and the risk factors which could affect recovery time of HPA axis had not been extensively studied. This study aimed to analyze the duration of CAI and explore the risk factors affecting HPA axis recovery in post-operative CD patients with biochemical remission.

Cushing's Syndrome Presenting as Non-Atherosclerotic Myocardial Infarction and Heart Failure

Fri, 02 Oct 2026 05:00:00 EST

(Fri, 02 Oct 2026 )

Cushing's syndrome is a rare cause of myocardial infarction and heart failure. Herein, we report a female patient who presented acute myocardial infarction and heart failure with reduced ejection fraction. The patient was found to have hypercortisolism secondary to adrenocortical adenoma and responded well to therapy. This case underlines the effects of hypercortisolism on the cardiovascular system. The clinical presentation of this patient is unique because non-atherosclerotic myocardial infarction is rarely reported in Cushing's syndrome patients.

Dee (Dee), Pituitary Bio

Fri, 02 Oct 2026 05:00:00 EST

(Fri, 02 Oct 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Fri, 02 Oct 2026 06:00:00 EST

(Fri, 02 Oct 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Anonymous Woman, Recurrent Cushing's

Fri, 02 Oct 2026 06:00:00 EST

(Fri, 02 Oct 2026 )

A 45-year-old female developed clinical and biochemical recurrent Cushings’ Disease 2.5 years after transsphenoidal hypophysectomy for 2cm pituitary macroadenoma.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Fri, 02 Oct 2026 07:00:00 EST

(Fri, 02 Oct 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Comment added to Day 2, Cushing’s Awareness Challenge

Fri, 02 Oct 2026 07:00:00 EST

(Fri, 02 Oct 2026 )

Even though this was from two years ago, I don't think that there have been any significant changes in the many symptoms of Cushing's.

Today's News Item proclaimed loftily

Quote

“This multimodal imaging technique provides a welcome improvement for diagnosis, planning of surgery, and clinical outcome in patients with Cushing disease,” the authors wrote.

But will enough doctors actually allow patients to get that far or will they still blow them off?

From https://cushings.invisionzone.com/topic/56737-day-2-cushing%E2%80%99s-awareness-challenge-2022/?do=findComment&comment=478717

Accidental Cushing Syndrome

Fri, 02 Oct 2026 08:00:00 EST

(Fri, 02 Oct 2026 )

We present a patient with Cushing syndrome secondary to accidental intake of corticosteroid tablets—a 66-year-old woman with a history of well-controlled hypertension, who over the course of a few weeks developed full-blown Cushing syndrome with uncontrolled blood pressure, typical central fat accumulation, and easy bruising.

TikTok Saved My Life: Student Discovers Life-threatening Tumour After Self-diagnosing Rare Condition

Fri, 02 Oct 2026 10:00:00 EST

(Fri, 02 Oct 2026 )

Did't we all do this?

A young woman saved her own life after successfully self-diagnosing cancer/Cushing's that doctors had missed because she researched her own worrying symptoms on TikTok.

https://cushings.invisionzone.com/topic/57819-tiktok-saved-my-life-student-discovers-life-threatening-tumour-after-self-diagnosing-rare-condition/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Fri, 02 Oct 2026 10:00:00 EST

(Fri, 02 Oct 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Fri, 02 Oct 2026 11:00:00 EST

(Fri, 02 Oct 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Connecting Canine and Human Health to Fight Cushing’s Disease

Fri, 02 Oct 2026 11:00:00 EST

(Fri, 02 Oct 2026 )

Cushing’s Disease is common in dogs but rare and hard to diagnose in people. That’s why University of Georgia researchers are leveraging canine treatments to find new solutions to battle the condition in humans. This collaboration between veterinary medicine and human health care is just one example of how UGA uses a Precision One Health approach to find and tailor new medical treatments for people and animals.

https://cushings.invisionzone.com/topic/57820-connecting-canine-and-human-health-to-fight-cushing%E2%80%99s-disease/

Margaret S (Maggierose), Possible Adrenal Bio

Fri, 02 Oct 2026 15:00:00 EST

(Fri, 02 Oct 2026 )

I had very, very thick hair and it’s now extremely thin. I have a type of rash on my face which has got worse over the years. It seems like my legs and arms are much thinner than they used to be but my abdomen is getting larger, mainly my upper abdomen. I don’t have any stria but have similar marks on my legs especially around my knees. My skin marks easily. I also seem to have a small buffalo hump on my back. Seem to have brain fog but usually put that down to age. Feel tired all the time.

https://cushingsbios.com/2025/10/01/margaret-s-maggierose-possible-adrenal-bio/

In Memory: Alice Baker

Sat, 03 Oct 2026 01:00:00 EST

(Sat, 03 Oct 2026 )

Thursday, October 3, 2002

Alice died of lung cancer and Cushing’s.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sat, 03 Oct 2026 03:00:00 EST

(Sat, 03 Oct 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Comment added to Day 3: Cushing’s Awareness Challenge

Sat, 03 Oct 2026 04:00:00 EST

(Sat, 03 Oct 2026 )

Wow - a lot has happened since I first shared this post. If you look at the timestamp, I'm writing this at 4:20 am and I've been awake for an hour, even though I'm exhausted.

I have been back on Growth Hormone although it doesn't seem to do me any good.

Ectopic Adrenocorticotropic Hormone-Secreting Pheochromocytoma with Severe Metabolic Disturbances: A Case Report

Sat, 03 Oct 2026 05:00:00 EST

(Sat, 03 Oct 2026 )

The patient is a 46-year-old male who presented to our hospital with recurrent symptoms of pheochromocytoma. He reported that he experienced unexplained symptoms such as panic attacks, headache, sweating, nausea, vomiting, and a feeling of imminent death, which could be alleviated by rest.

Adrenal insufficiency Basics

Sat, 03 Oct 2026 05:00:00 EST

(Sat, 03 Oct 2026 )

Adrenal insufficiency is a condition where the adrenal glands don't produce enough of certain hormones, primarily cortisol and sometimes aldosterone. This disorder can be categorized into primary (Addison's disease) and secondary forms.

https://cushings.invisionzone.com/topic/57788-adrenal-insufficiency/

Dee (Dee), Pituitary Bio

Sat, 03 Oct 2026 05:00:00 EST

(Sat, 03 Oct 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sat, 03 Oct 2026 06:00:00 EST

(Sat, 03 Oct 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Janet (janetelizabeth), Adrenal Bio

Sat, 03 Oct 2026 06:00:00 EST

(Sat, 03 Oct 2026 )

I have recently been diagnosed with cushings syndrome and awaiting removal of gland and tumour.

https://cushingsbios.com/2025/11/07/janet-janetelizabeth-adrenal-bio/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sat, 03 Oct 2026 07:00:00 EST

(Sat, 03 Oct 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Cushing’s Myths and Facts

Sat, 03 Oct 2026 08:00:00 EST

(Sat, 03 Oct 2026 )

Dr. Karen Thames shared these on her Facebook Page, Empowering People with Invisible Chronic Illness – The EPIC Foundation

She has graciously given me permission to share them here and in the CushieWiki and on the Cushing’s Help message boards.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Sat, 03 Oct 2026 08:00:00 EST

(Sat, 03 Oct 2026 )

Cushing's Basics: What is Cortisol?

Sat, 03 Oct 2026 09:00:00 EST

(Sat, 03 Oct 2026 )

Cortisol is a hormone which produced by the adrenal gland (cortex) to control blood sugar. The production of cortisol is triggered by the pituitary hormone ACTH. Cortisol is a glucocorticoid which stimulates an increase in blood glucose. Cortisol will also stimulate the release of amino acids from muscle tissue and fatty acids from adipose tissue. The amino acids are then converted in the liver to glucose (for use by the brain). The fatty acids can be used by skeletal muscles for energy (rather than glucose) thereby freeing up glucose for selective utilization by the brain. Cortisol levels are often measured to evaluate the function of the pituitary or adrenal glands. Some of the cortisol is metabolized by the liver to produce 17 hydroxycorticosteroids, which is then excreted in the urine.

Diabetic Ketoacidosis as the First Manifestation of Ectopic Cushing’s Syndrome

Sat, 03 Oct 2026 09:00:00 EST

(Sat, 03 Oct 2026 )

Diabetic ketoacidosis is an exceptionally rare initial manifestation of ectopic adrenocorticotropic hormone (ACTH) syndrome. A 42-year-old woman with multiple cardiovascular risk factors was admitted to the emergency room with diabetic ketoacidosis.

https://cushings.invisionzone.com/topic/57925-diabetic-ketoacidosis-as-the-first-manifestation-of-ectopic-cushing%E2%80%99s-syndrome/

Prevalence of Nelson’s Syndrome After Bilateral Adrenalectomy in Patients with Cushing’s Disease

Sat, 03 Oct 2026 10:00:00 EST

(Sat, 03 Oct 2026 )

Bilateral adrenalectomy (BA) still plays an important role in the management of Cushing's disease (CD). Nelson’s syndrome (NS) is a severe complication of BA, but conflicting data on its prevalence and predicting factors have been reported. The aim of this study was to determine the prevalence of NS, and identify factors associated with its development.

Call 911! Adrenal Crisis, Addison's/Adrenal Insufficiency

Sat, 03 Oct 2026 10:00:00 EST

(Sat, 03 Oct 2026 )

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Xeris Presents New Post Hoc Analysis on Effects of Levoketoconazole (Recorlev®) in Cushing’s Syndrome Patients at ENDO 2024

Sat, 03 Oct 2026 10:00:00 EST

(Sat, 03 Oct 2026 )

Cases of hepatotoxicity with fatal outcome or requiring liver transplantation have been reported with oral ketoconazole. Some patients had no obvious risk factors for liver disease. Recorlev is associated with serious hepatotoxicity. Evaluate liver enzymes prior to and during treatment.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sat, 03 Oct 2026 10:00:00 EST

(Sat, 03 Oct 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Hypercoagulability in Cushing Syndrome

Sat, 03 Oct 2026 10:00:00 EST

(Sat, 03 Oct 2026 )

This case highlights the necessity of providers to be aware of potential complications of endocrinological disorders. The risk of thromboembolism is more commonly present in patients with Cushing syndrome, who have risk factors such as obesity, surgery and invasive diagnostic procedures.

https://cushings.invisionzone.com/topic/57876-hypercoagulability-in-cushing-syndrome/

Kind Words for Cushing’s Awareness Month

Sat, 03 Oct 2026 11:00:00 EST

(Sat, 03 Oct 2026 )

Through the newly available dial-up internet, I joined forces with a small group of wonderful Cushing’s advocates. Cathy Gifford and Mary O’Connor, were my first Cushing’s friends, and are still dear friends twenty one years later. Together we got things moving. Mary, has built the largest Cushing’s support boards, and her admirable dedication continues to help and support patients from all over the world, Cushing’s Help and Support (cushings-help.com).

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sat, 03 Oct 2026 11:00:00 EST

(Sat, 03 Oct 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

Sat, 03 Oct 2026 13:00:00 EST

(Sat, 03 Oct 2026 )

The pituitary gland produces hormones. A tumor in this gland can cause it to produce too much of the hormone cortisol. Too much cortisol in the body causes Cushing disease. This disease causes many problems. Some of these problems might persist after the disease is cured.

Research Study for Patients Diagnosed with Cushing's Disease and Their Caregivers

Sat, 03 Oct 2026 15:00:00 EST

(Sat, 03 Oct 2026 )

We’re looking for caregivers to loved ones diagnosed with Cushing's Disease or patients diagnosed with Cushing's Disease to participate in a research study.

Who: Patients and caregivers of loved ones

What: 30-minute Online Survey

Compensation: $60.00

Sign up here: https://rarepatientvoice.com/CushingsHelp/

Alma (Diane), Adrenal Bio

Sat, 03 Oct 2026 15:00:00 EST

(Sat, 03 Oct 2026 )

I have been diagnosed with Subclinical Cushings Disease.

Also, included in that diagnose is rare form of cushings; Amiah macnodular independent hyperplasia?

https://cushingsbios.com/2025/10/02/alma-diane-adrenal-bio/

Video: Cushing’s Disease-Pituitary Gland

Sat, 03 Oct 2026 18:00:00 EST

(Sat, 03 Oct 2026 )

Sharmyn McGraw searched for answers for seven years for whatever it was that was killing her; finally she diagnosed herself via the Internet with Cushing’s disease, caused by a pituitary brain tumor.

See the video at https://cushieblogger.com/2019/04/03/video-cushings-disease-pituitary-gland/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 04 Oct 2026 03:00:00 EST

(Sun, 04 Oct 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dee (Dee), Pituitary Bio

Sun, 04 Oct 2026 05:00:00 EST

(Sun, 04 Oct 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 04 Oct 2026 06:00:00 EST

(Sun, 04 Oct 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 04 Oct 2026 07:00:00 EST

(Sun, 04 Oct 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Thymic Neuroendocrine Tumor With Metastasis to the Breast Causing Ectopic Cushing’s Syndrome

Sun, 04 Oct 2026 07:00:00 EST

(Sun, 04 Oct 2026 )

We present a case of a 34-year-old woman with a rapid onset of severe hypercortisolism in April 2016. After initial treatment with a steroid inhibitor (ketoconazole) and diagnostics including 68Ga DOTA-TATE PET/CT, it was shown to be caused by a small thymic NET.

https://cushings.invisionzone.com/topic/57807-thymic-neuroendocrine-tumor-with-metastasis-to-the-breast-causing-ectopic-cushing%E2%80%99s-syndrome/

FDA Grants Breakthrough Therapy Designation for Oral Congenital Adrenal Hyperplasia Drug

Sun, 04 Oct 2026 08:00:00 EST

(Sun, 04 Oct 2026 )

The FDA granted breakthrough therapy designation for an oral non-glucocorticoid medication for the treatment of congenital adrenal hyperplasia, according to an industry press release.

Crinecerfont (Neurocrine Biosciences) is a selective corticotropin-releasing factor type 1 receptor antagonist under development to lower excess adrenal androgens for people with congenital adrenal hyperplasia due to 21-hyroxylase deficiency.

Basics: The Pituitary Gland: Small But Mighty

Sun, 04 Oct 2026 09:00:00 EST

(Sun, 04 Oct 2026 )

“The pituitary is commonly referred to as the ‘master’ gland because it does so many important jobs in the body,” says Karen Frankwich, MD, a board-certified endocrinologist at Mission Hospital. “Not only does the pituitary make its own hormones, but it also triggers hormone production in other glands. The pituitary is aided in its job by the hypothalamus. This part of the brain is situated above the pituitary, and sends messages to the gland on when to release or stimulate production of necessary hormones.”

Complete and Sustained Remission of Hypercortisolism With Pasireotide Treatment of an Adrenocorticotropic Hormone (Acth)-Secreting Thoracic Neuroendocrine Tumour: an N-Of-1 Trial

Sun, 04 Oct 2026 09:00:00 EST

(Sun, 04 Oct 2026 )

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Fulminant Ectopic Cushing’s Syndrome Caused by Metastatic Small Intestine Neuroendocrine Tumour

Sun, 04 Oct 2026 09:00:00 EST

(Sun, 04 Oct 2026 )

This review is illustrated by the case of a 75-year old woman with fulminant ectopic Cushing's Syndrome caused by a ACTH-secreting metastatic siNET. Severe hypokalemia, fluid retention and refractory hypertension were the presenting symptoms.

Restoration of Intra-patient Variability and Diurnal Range of ACTH with Remission in Cushing’s Disease

Sun, 04 Oct 2026 10:00:00 EST

(Sun, 04 Oct 2026 )

The following is a summary of “Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing’s Disease,” published in the November 2023 issue of Endocrinology by Alvarez, et al.

Can you Help? Cyclic Cushing's?

Sun, 04 Oct 2026 10:00:00 EST

(Sun, 04 Oct 2026 )

I'm also noticing physical symptoms such as new patches of hair on my back, hyperpigmentation of my knuckles, knee and elbow, high blood pressure, bruises that heal dark as well as the severe nervousness and anxiety. Given my tests and symptoms that are on a cycle, can this be cyclic cushing's?

https://cushings.invisionzone.com/topic/57738-can-i-be-cyclic/

‘Cortisol Face’ Is Real, But It’s Not As Common As You Might Think

Sun, 04 Oct 2026 10:00:00 EST

(Sun, 04 Oct 2026 )

High levels of the stress hormone cortisol can cause the face to gradually swell into a rounded shape and is often the result of prolonged use of corticosteroids, Cushing syndrome or other underlying medical issues.

https://cushings.invisionzone.com/topic/57757-%E2%80%98cortisol-face%E2%80%99-is-real-but-it%E2%80%99s-not-as-common-as-you-might-think/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 04 Oct 2026 10:00:00 EST

(Sun, 04 Oct 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease

Sun, 04 Oct 2026 11:00:00 EST

(Sun, 04 Oct 2026 )

Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic exposure to excess cortisol has detrimental effects on health, including increased stroke rates, diabetes, obesity, cognitive impairment, anxiety, depression, and death. The first-line treatment for CD is pituitary surgery. Current surgical remission rates reported in only 56% of patients depending on several criteria. The lack of specificity, poor tolerability, and low efficacy of the subsequent second-line medical therapies make CD a medical therapeutic challenge. One major limitation that hinders the development of specific medical therapies is the lack of relevant human model systems that recapitulate the cellular composition of PitNET microenvironment.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 04 Oct 2026 11:00:00 EST

(Sun, 04 Oct 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Adrenal Insufficiency Common After Adrenalectomy for Mild Autonomous Cortisol Secretion

Sun, 04 Oct 2026 11:00:00 EST

(Sun, 04 Oct 2026 )

More than half of adults who underwent a unilateral adrenalectomy to treat mild autonomous cortisol secretion developed adrenal insufficiency,

https://cushings.invisionzone.com/topic/57891-adrenal-insufficiency-common-after-adrenalectomy-for-mild-autonomous-cortisol-secretion/

A Preliminary Model to Tailor Osilodrostat In Patients With Adrenocorticotropic Hormone (ACTH)-Sependent Cushing's syndrome

Sun, 04 Oct 2026 15:00:00 EST

(Sun, 04 Oct 2026 )

Over the past 10 years, osilodrostat has become one of the most commonly used steroidogenesis inhibitors in patients with Cushing's syndrome. The starting dose is usually determined based on the product characteristics, the prescriber's experience, and cortisol levels.

https://cushings.invisionzone.com/topic/57890-a-preliminary-model-to-tailor-osilodrostat-in-patients-with-adrenocorticotropic-hormone-acth-dependent-cushings-syndrome/

Denise H (deekay), Pituitary Bio

Sun, 04 Oct 2026 15:00:00 EST

(Sun, 04 Oct 2026 )

I had been having some of the same issues and symptoms as when i first went to doctor that started coming up this is why i asked for blood test in first place and they are stating with meds and my own levels i am once again overproducing makes sense. However i am not feeling well at all severe muscle pains in knees and feel like i need a crane to get out of bed from being so stiff everyday.

https://cushingsbios.com/2025/10/04/denise-h-deekay-pituitary-bio/

From a Past Blogging Challenge: Cushing’s Awareness Challenge ~ Danielle, Day 4

Sun, 04 Oct 2026 16:00:00 EST

(Sun, 04 Oct 2026 )

I have often said, I wish I had cancer instead. Most people would not understand this sentiment, why in the world would you wish for such a horrible disease?...

What Do You Think? Only One Urine Test for Cushing's?

Sun, 04 Oct 2026 16:00:00 EST

(Sun, 04 Oct 2026 )

I sure had way more than one urine test, and lots of blood and more but that was a long time ago. What are your thoughts on this?

Let us know at https://cushings.invisionzone.com/topic/57689-what-do-you-think-only-one-urine-test-for-cushings/

Cushing’s Syndrome: A New Drug Allows You To Avoid Surgery

Sun, 04 Oct 2026 17:00:00 EST

(Sun, 04 Oct 2026 )

The Cushing’s syndrome, a disease caused by the excessive production of cortisol by the pituitary gland due to a benign tumor of the gland, has seen a breakthrough in its treatment. Thanks to a new drug called osilodrostat, approved in 2020 by the Food and Drug Administration and subsequently by Aifa in Italy, patients unfit for surgery can benefit from a treatment that offers the same effects as a scalpel. Furthermore, this drug reduced symptoms in 80% of cases.