Cushie Calendar (Cushie)

In Memory of Kathryn McBride 'Bridie' Miller ~ May 1, 2007

Fri, 01 May 2026 01:00:00 EST

(Fri, 01 May 2026 )

Murdered May 1, 2007

'My name is Caroline and I dont post often but have met a few of you guys and read the board regularly, it has definitely been a godsend to cushies everywhere. The reason I am writing tonight is I have just received devastating information about a dear friend of mine, and a woman some of you may have met during testing. Her name is Kathryn Miller and she is a patient of Dr. Ludlam, that is how she and I met. She was diagnosed with cushings late last fall and had surgery in December and was doing pretty well afterwards...'

Investigational Cushing’s Syndrome Medication Reduces BP, Glucose in Open-Label Trial

Fri, 01 May 2026 03:00:00 EST

(Fri, 01 May 2026 )

Relacorilant was deemed well tolerated in the trial. The most common adverse events were nausea, edema, back and extremity pain and fatigue, all of which were mild or moderate in nature and are consistent with symptoms people experience after surgery or the start of therapy to treat hypercortisolism.

Ivory Tower: New PET Scan Molecule Offers Breakthrough in Detecting Cushing’s Syndrome

Fri, 01 May 2026 03:00:00 EST

(Fri, 01 May 2026 )

Researchers from endocrinology and nuclear medicine departments have introduced a new PET scan molecule that enhances the detection of adenoma/small tumour causing Cushing’s syndrome. This development promises to improve surgical interventions and patient outcomes.

https://cushings.invisionzone.com/topic/57806-ivory-tower-new-pet-scan-molecule-offers-breakthrough-in-detecting-cushing%E2%80%99s-syndrome/

Ectopic ACTH-secreting Pheochromocytoma Without Typical Signs of Cushing Syndrome

Fri, 01 May 2026 03:00:00 EST

(Fri, 01 May 2026 )

Abstract

This case report describes a 42-year-old female with a rare pheochromocytoma presenting without classic Cushingoid features but with uncontrolled hypertension, type 2 diabetes, and recurrent headaches. Despite the absence of typical signs, biochemical analysis revealed elevated cortisol and ACTH levels, and imaging showed a 6 cm adrenal mass. The patient was stabilized preoperatively with alpha-blockers and metyrapone before undergoing a successful laparoscopic adrenalectomy. Histopathology confirmed pheochromocytoma with aggressive features. Postoperatively, her blood pressure and symptoms improved, and her cortisol levels normalized. This case underscores the diagnostic challenges of ACTH-secreting pheochromocytomas without classic hypercortisolism signs and emphasizes the need for thorough endocrine and imaging assessments. Surgical resection remains the definitive treatment, with long-term follow-up essential to monitor for recurrence. This case contributes to the limited literature on the coexistence of pheochromocytoma and ectopic ACTH secretion.

https://cushings.invisionzone.com/topic/57818-ectopic-acth-secreting-pheochromocytoma-without-typical-signs-of-cushing-syndrome/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Fri, 01 May 2026 03:00:00 EST

(Fri, 01 May 2026 )

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Liver impairment and medical management of Cushing Syndrome and MACSProvisionally

Fri, 01 May 2026 03:00:00 EST

(Fri, 01 May 2026 )

Cushing syndrome (CS) and Mild Autonomous Cortisol Secretion syndrome (MACS) are states of endogenous hypercortisolemia, associated with multiple metabolic complications.

https://cushings.invisionzone.com/topic/57887-liver-impairment-and-medical-management-of-cushing-syndrome-and-macs-provisionally/

Global Longitudinal Strain Reduction With Apical Sparing in Cushing Syndrome-Related Heart Failure With Preserved Ejection Fraction (HFpEF)

Fri, 01 May 2026 03:00:00 EST

(Fri, 01 May 2026 )

We describe a case of a 56-year-old woman with a history of recurrent pituitary adenoma, not well followed, and known comorbidities of coronary artery disease, hypertension, and type 2 diabetes mellitus. She arrived with severely high blood pressure and signs pointing to hypercortisolism. Further evaluation revealed left ventricular hypertrophy, reduced global longitudinal strain, and preserved left ventricular ejection fraction, consistent with heart failure with preserved ejection fraction (HFpEF). Workup for amyloidosis was negative.

This case highlights that chronic hypercortisolism may cause pathophysiological changes in the heart, leading to HFpEF, and may induce myocardial fibrosis and impaired myocardial mechanics, producing an echocardiographic pattern that can mimic infiltrative cardiomyopathy. Recognition of this overlap is crucial to avoid misdiagnosis and to ensure timely endocrine and cardiovascular management.

https://cushings.invisionzone.com/topic/57888-global-longitudinal-strain-reduction-with-apical-sparing-in-cushing-syndrome-related-heart-failure-with-preserved-ejection-fraction-hfpef/

Basics: What Causes Abnormal Cortisol Levels?

Fri, 01 May 2026 04:00:00 EST

(Fri, 01 May 2026 )

“In general, cortisol levels tend to peak in the late morning and gradually decline throughout the day,” he explains. “When a stressful event occurs, the increased cortisol will work alongside our ‘fight or flight’ mechanisms to either upregulate or downregulate bodily functions. [Affected systems include] the central nervous system, cardiovascular system, gastrointestinal system, or immune system.”

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Fri, 01 May 2026 06:00:00 EST

(Fri, 01 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Sleep Impairment Similar in Cushing Syndrome, Mild Autonomous Cortisol Secretion

Fri, 01 May 2026 06:00:00 EST

(Fri, 01 May 2026 )

Patients with Cushing syndrome and mild autonomous cortisol secretion experienced similar degrees of sleep impairment.

https://cushings.invisionzone.com/topic/57907-sleep-impairment-similar-in-cushing-syndrome-mild-autonomous-cortisol-secretion/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Fri, 01 May 2026 07:00:00 EST

(Fri, 01 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

“The Healthcare System Did Fail Me Repeatedly”: a Qualitative Study On Experiences Of Healthcare Among Canadian Women With Cushing’s Syndrome

Fri, 01 May 2026 07:00:00 EST

(Fri, 01 May 2026 )

As a rare endocrine disorder, Cushing’s Syndrome (Cushing’s) is characterized by numerous symptoms and a non-specific presentation, leading to a delay to diagnosis for patients with this disease. To date, research examining the lived experiences of patients with Cushing’s in healthcare is absent in the literature. This preliminary inquiry into the healthcare experiences of women with Cushing’s aimed to examine the utility of this line of inquiry to support the patient centered care of individuals with Cushing’s.

https://cushings.invisionzone.com/topic/57759-%E2%80%9Cthe-healthcare-system-did-fail-me-repeatedly%E2%80%9D-a-qualitative-study-on-experiences-of-healthcare-among-canadian-women-with-cushing%E2%80%99s-syndrome/

Comment added to Day 1: Cushing's Awareness Challenge 2024

Fri, 01 May 2026 08:00:00 EST

(Fri, 01 May 2026 )

While American actress Amy Schumer is spreading the word about Cushing’s in general, I think that in some ways she is hurting things for everyone else. CBS News reports that “she says she now feels ‘reborn’ after her diagnosis, and while some forms of Cushing can be fatal, she has a type that ‘will just work itself out.’”

How many others will try to get diagnosed and only be told not to worry, that it “will just work itself out”?

The STUB1-TPIT Axis Regulates the Secretion of Adrenocorticotrophic Hormone in Cushing Disease

Fri, 01 May 2026 09:00:00 EST

(Fri, 01 May 2026 )

Cushing’s disease (CD) is a clinical syndrome caused by excessive secretion of adrenocorticotropic hormone (ACTH) from a pituitary corticotroph adenoma, resulting in adrenal cortical hyperplasia and overproduction of cortisol. The T-box transcription factor (TPIT) is crucial for regulating ACTH secretion in pituitary corticotroph adenomas. This study aims to explore the ubiquitin-mediated degradation of TPIT and identify potential pharmaceutical agents for treating CD.

https://cushings.invisionzone.com/topic/57874-the-stub1-tpit-axis-regulates-the-secretion-of-adrenocorticotrophic-hormone-in-cushing-disease/

Adults with Cushing’s Syndrome Report High Burden Of Illness, Despite Ongoing Treatment

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

Key takeaways:

Cushing’s syndrome symptoms moderately impact quality of life for adults with the condition.
Weight gain, muscle fatigue and menstrual changes decline in severity from diagnosis to follow-up.

Adrenocorticotropic Hormone-Dependent Cushing's Syndrome Complicated With Gastric Ulcer Perforation in a 30-Year-Old Saudi Female

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

We report a case of a recently diagnosed adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome in a 30-years-old female who presented initially with a three-month history of progressive weight gain, generalized weakness, acne, menstrual irregularity, and severe hypokalemia, and then developed a gastric ulcer perforation only one month after her ACTH-dependent Cushing's syndrome diagnosis and was managed through emergent surgery.

Cardiac Magnetic Resonance Reveals Biventricular Impairment In Cushing’s Syndrome

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

Cushing’s syndrome (CS) is associated with severe cardiovascular (CV) morbidity and mortality. Cardiac magnetic resonance (CMR) is the non-invasive gold standard for assessing cardiac structure and function; however, few CMR studies explore cardiac remodeling in patients exposed to chronic glucocorticoid (GC) excess. We aimed to describe the CMR features directly attributable to previous GC exposure in patients with cured or treated endogenous CS.

Impact of Remission Status in Endogenous Cushing's Syndrome on Cancer Incidence

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

Endogenous Cushing's syndrome (CS) has been linked with an increased risk of cancer. We aimed to evaluate the association between cancer risk and disease remission post-surgery in adrenal CS and Cushing's disease (CD).

https://cushings.invisionzone.com/topic/57786-impact-of-remission-status-in-endogenous-cushings-syndrome-on-cancer-incidence/

TikTok Saved My Life: Student Discovers Life-threatening Tumour After Self-diagnosing Rare Condition

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

Did't we all do this?

A young woman saved her own life after successfully self-diagnosing cancer/Cushing's that doctors had missed because she researched her own worrying symptoms on TikTok.

https://cushings.invisionzone.com/topic/57819-tiktok-saved-my-life-student-discovers-life-threatening-tumour-after-self-diagnosing-rare-condition/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

A Silent Invader: Asymptomatic Rhodococcus Infection Unmasked In a Patient With Ectopic ACTH-Dependent Cushing’s Syndrome

Fri, 01 May 2026 10:00:00 EST

(Fri, 01 May 2026 )

We report the case of a 29-year-old male who presented with new-onset diabetes mellitus, resistant hypertension and significant weight gain. Physical examination revealed features consistent with Cushing’s syndrome.

https://cushings.invisionzone.com/topic/57889-a-silent-invader-asymptomatic-rhodococcus-infection-unmasked-in-a-patient-with-ectopic-acth-dependent-cushing%E2%80%99s-syndrome/

Pituitary Surgery Outcome in Patients 75 Years and Older

Fri, 01 May 2026 11:00:00 EST

(Fri, 01 May 2026 )

Surgery beyond the age of 75, mainly relying on an endoscopic endonasal transsellar approach, is effective and safe, provided that patients are managed in tertiary centers.

Corcept’s relacorilant GRADIENT trial misses primary endpoint

Fri, 01 May 2026 11:00:00 EST

(Fri, 01 May 2026 )

The Phase III GRADIENT trial for relacorilant has missed its primary endpoint of improving SBP for Cushing's syndrome patients.

https://cushings.invisionzone.com/topic/57763-corcept%E2%80%99s-relacorilant-gradient-trial-misses-primary-endpoint/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Fri, 01 May 2026 11:00:00 EST

(Fri, 01 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

How is Cushing's Disease Diagnosed?

Fri, 01 May 2026 11:00:00 EST

(Fri, 01 May 2026 )

Diagnosing Cushing's disease involves a series of tests to confirm excessive cortisol production and determine its source.

https://cushings.invisionzone.com/topic/57787-how-is-cushings-disease-diagnosed/

What Do You Think? Alternate Treatments

Fri, 01 May 2026 17:00:00 EST

(Fri, 01 May 2026 )

Has your doctor ever tried to dissuade you from using an alternative treatment?

In Memory of Patti ~ May 2, 2002

Sat, 02 May 2026 01:00:00 EST

(Sat, 02 May 2026 )

May 2, 2002

From the Message Boards: ” I loved her, she was a great friend. She died of adrenal cortical carcinoma.”

PET/MRI may improve diagnosis of Cushing disease

Sat, 02 May 2026 02:00:00 EST

(Sat, 02 May 2026 )

In patients diagnosed with the disease yet who had inconclusive MRI results, PET/MRI was positive in 100% of cases, noted lead author Ilanah Pruis, a doctoral student at Erasmus University Medical Center in Rotterdam, Netherlands.

“This multimodal imaging technique provides a welcome improvement for diagnosis, planning of surgery, and clinical outcome in patients with Cushing disease,” the authors wrote.

Myocardial Work Impairment in Patients With Cushing’s Syndrome

Sat, 02 May 2026 03:00:00 EST

(Sat, 02 May 2026 )

Endogenous Cushing’s Syndrome (CS) is associated with an increased cardiovascular (CV) and metabolic risk profile, yet the specific impact of hypercortisolism on myocardial function remains inadequately understood.

https://cushings.invisionzone.com/topic/57805-myocardial-work-impairment-in-patients-with-cushing%E2%80%99s-syndrome/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sat, 02 May 2026 03:00:00 EST

(Sat, 02 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Preop TT3 Predicts HPA Axis Recovery After Cushing Surgery

Sat, 02 May 2026 04:00:00 EST

(Sat, 02 May 2026 )

Patients with Cushing’s disease (CD) experienced transient central adrenal insufficiency (CAI) after successful surgery. However, the reported recovery time of hypothalamic-pituitary-adrenal (HPA) axis varied and the risk factors which could affect recovery time of HPA axis had not been extensively studied. This study aimed to analyze the duration of CAI and explore the risk factors affecting HPA axis recovery in post-operative CD patients with biochemical remission.

Cushing's Syndrome Presenting as Non-Atherosclerotic Myocardial Infarction and Heart Failure

Sat, 02 May 2026 05:00:00 EST

(Sat, 02 May 2026 )

Cushing's syndrome is a rare cause of myocardial infarction and heart failure. Herein, we report a female patient who presented acute myocardial infarction and heart failure with reduced ejection fraction. The patient was found to have hypercortisolism secondary to adrenocortical adenoma and responded well to therapy. This case underlines the effects of hypercortisolism on the cardiovascular system. The clinical presentation of this patient is unique because non-atherosclerotic myocardial infarction is rarely reported in Cushing's syndrome patients.

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sat, 02 May 2026 06:00:00 EST

(Sat, 02 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Anonymous Woman, Recurrent Cushing's

Sat, 02 May 2026 06:00:00 EST

(Sat, 02 May 2026 )

A 45-year-old female developed clinical and biochemical recurrent Cushings’ Disease 2.5 years after transsphenoidal hypophysectomy for 2cm pituitary macroadenoma.

Janet (janetelizabeth), Adrenal Bio

Sat, 02 May 2026 06:00:00 EST

(Sat, 02 May 2026 )

I have recently been diagnosed with cushings syndrome and awaiting removal of gland and tumour.

https://cushingsbios.com/2025/11/07/janet-janetelizabeth-adrenal-bio/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sat, 02 May 2026 07:00:00 EST

(Sat, 02 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Comment added to Day 2, Cushing’s Awareness Challenge

Sat, 02 May 2026 07:00:00 EST

(Sat, 02 May 2026 )

Even though this was from two years ago, I don't think that there have been any significant changes in the many symptoms of Cushing's.

Today's News Item proclaimed loftily

Quote

“This multimodal imaging technique provides a welcome improvement for diagnosis, planning of surgery, and clinical outcome in patients with Cushing disease,” the authors wrote.

But will enough doctors actually allow patients to get that far or will they still blow them off?

From https://cushings.invisionzone.com/topic/56737-day-2-cushing%E2%80%99s-awareness-challenge-2022/?do=findComment&comment=478717

What Was the Most Memorable Thing that Happened to YOU Last Year?

Sat, 02 May 2026 08:00:00 EST

(Sat, 02 May 2026 )

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult. My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Accidental Cushing Syndrome

Sat, 02 May 2026 08:00:00 EST

(Sat, 02 May 2026 )

We present a patient with Cushing syndrome secondary to accidental intake of corticosteroid tablets—a 66-year-old woman with a history of well-controlled hypertension, who over the course of a few weeks developed full-blown Cushing syndrome with uncontrolled blood pressure, typical central fat accumulation, and easy bruising.

Cushing's Basics: What is Cortisol?

Sat, 02 May 2026 09:00:00 EST

(Sat, 02 May 2026 )

Cortisol is a hormone which produced by the adrenal gland (cortex) to control blood sugar. The production of cortisol is triggered by the pituitary hormone ACTH. Cortisol is a glucocorticoid which stimulates an increase in blood glucose. Cortisol will also stimulate the release of amino acids from muscle tissue and fatty acids from adipose tissue. The amino acids are then converted in the liver to glucose (for use by the brain). The fatty acids can be used by skeletal muscles for energy (rather than glucose) thereby freeing up glucose for selective utilization by the brain. Cortisol levels are often measured to evaluate the function of the pituitary or adrenal glands. Some of the cortisol is metabolized by the liver to produce 17 hydroxycorticosteroids, which is then excreted in the urine.

Prevalence of Nelson’s Syndrome After Bilateral Adrenalectomy in Patients with Cushing’s Disease

Sat, 02 May 2026 10:00:00 EST

(Sat, 02 May 2026 )

Bilateral adrenalectomy (BA) still plays an important role in the management of Cushing's disease (CD). Nelson’s syndrome (NS) is a severe complication of BA, but conflicting data on its prevalence and predicting factors have been reported. The aim of this study was to determine the prevalence of NS, and identify factors associated with its development.

Call 911! Adrenal Crisis, Addison's/Adrenal Insufficiency

Sat, 02 May 2026 10:00:00 EST

(Sat, 02 May 2026 )

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sat, 02 May 2026 10:00:00 EST

(Sat, 02 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sat, 02 May 2026 11:00:00 EST

(Sat, 02 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

Sat, 02 May 2026 13:00:00 EST

(Sat, 02 May 2026 )

The pituitary gland produces hormones. A tumor in this gland can cause it to produce too much of the hormone cortisol. Too much cortisol in the body causes Cushing disease. This disease causes many problems. Some of these problems might persist after the disease is cured.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 03 May 2026 03:00:00 EST

(Sun, 03 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Comment added to Day 3: Cushing’s Awareness Challenge

Sun, 03 May 2026 04:00:00 EST

(Sun, 03 May 2026 )

Wow - a lot has happened since I first shared this post. If you look at the timestamp, I'm writing this at 4:20 am and I've been awake for an hour, even though I'm exhausted.

I have been back on Growth Hormone although it doesn't seem to do me any good.

Ectopic Adrenocorticotropic Hormone-Secreting Pheochromocytoma with Severe Metabolic Disturbances: A Case Report

Sun, 03 May 2026 05:00:00 EST

(Sun, 03 May 2026 )

The patient is a 46-year-old male who presented to our hospital with recurrent symptoms of pheochromocytoma. He reported that he experienced unexplained symptoms such as panic attacks, headache, sweating, nausea, vomiting, and a feeling of imminent death, which could be alleviated by rest.

Adrenal insufficiency Basics

Sun, 03 May 2026 05:00:00 EST

(Sun, 03 May 2026 )

Adrenal insufficiency is a condition where the adrenal glands don't produce enough of certain hormones, primarily cortisol and sometimes aldosterone. This disorder can be categorized into primary (Addison's disease) and secondary forms.

https://cushings.invisionzone.com/topic/57788-adrenal-insufficiency/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 03 May 2026 06:00:00 EST

(Sun, 03 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 03 May 2026 07:00:00 EST

(Sun, 03 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Cushing’s Myths and Facts

Sun, 03 May 2026 08:00:00 EST

(Sun, 03 May 2026 )

Dr. Karen Thames shared these on her Facebook Page, Empowering People with Invisible Chronic Illness – The EPIC Foundation

She has graciously given me permission to share them here and in the CushieWiki and on the Cushing’s Help message boards.

Diabetic Ketoacidosis as the First Manifestation of Ectopic Cushing’s Syndrome

Sun, 03 May 2026 09:00:00 EST

(Sun, 03 May 2026 )

Diabetic ketoacidosis is an exceptionally rare initial manifestation of ectopic adrenocorticotropic hormone (ACTH) syndrome. A 42-year-old woman with multiple cardiovascular risk factors was admitted to the emergency room with diabetic ketoacidosis.

https://cushings.invisionzone.com/topic/57925-diabetic-ketoacidosis-as-the-first-manifestation-of-ectopic-cushing%E2%80%99s-syndrome/

Xeris Presents New Post Hoc Analysis on Effects of Levoketoconazole (Recorlev®) in Cushing’s Syndrome Patients at ENDO 2024

Sun, 03 May 2026 10:00:00 EST

(Sun, 03 May 2026 )

Cases of hepatotoxicity with fatal outcome or requiring liver transplantation have been reported with oral ketoconazole. Some patients had no obvious risk factors for liver disease. Recorlev is associated with serious hepatotoxicity. Evaluate liver enzymes prior to and during treatment.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 03 May 2026 10:00:00 EST

(Sun, 03 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Hypercoagulability in Cushing Syndrome

Sun, 03 May 2026 10:00:00 EST

(Sun, 03 May 2026 )

This case highlights the necessity of providers to be aware of potential complications of endocrinological disorders. The risk of thromboembolism is more commonly present in patients with Cushing syndrome, who have risk factors such as obesity, surgery and invasive diagnostic procedures.

https://cushings.invisionzone.com/topic/57876-hypercoagulability-in-cushing-syndrome/

Kind Words for Cushing’s Awareness Month

Sun, 03 May 2026 11:00:00 EST

(Sun, 03 May 2026 )

Through the newly available dial-up internet, I joined forces with a small group of wonderful Cushing’s advocates. Cathy Gifford and Mary O’Connor, were my first Cushing’s friends, and are still dear friends twenty one years later. Together we got things moving. Mary, has built the largest Cushing’s support boards, and her admirable dedication continues to help and support patients from all over the world, Cushing’s Help and Support (cushings-help.com).

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 03 May 2026 11:00:00 EST

(Sun, 03 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Research Study for Patients Diagnosed with Cushing's Disease and Their Caregivers

Sun, 03 May 2026 15:00:00 EST

(Sun, 03 May 2026 )

We’re looking for caregivers to loved ones diagnosed with Cushing's Disease or patients diagnosed with Cushing's Disease to participate in a research study.

Who: Patients and caregivers of loved ones

What: 30-minute Online Survey

Compensation: $60.00

Sign up here: https://rarepatientvoice.com/CushingsHelp/

Video: Cushing’s Disease-Pituitary Gland

Sun, 03 May 2026 18:00:00 EST

(Sun, 03 May 2026 )

Sharmyn McGraw searched for answers for seven years for whatever it was that was killing her; finally she diagnosed herself via the Internet with Cushing’s disease, caused by a pituitary brain tumor.

See the video at https://cushieblogger.com/2019/04/03/video-cushings-disease-pituitary-gland/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Mon, 04 May 2026 03:00:00 EST

(Mon, 04 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Corcept Completes Enrollment in Phase 3 Gradient Trial of Relacorilant in Patients With Adrenal Cushing’s Syndrome

Mon, 04 May 2026 04:00:00 EST

(Mon, 04 May 2026 )

“Hypercortisolism with adrenal etiology affects many patients and is associated with serious cardiometabolic comorbidities, including hypertension and hyperglycemia, and increased risk of premature death,” said Bill Guyer, PharmD, Corcept’s Chief Development Officer. “GRADIENT is the first prospective placebo-controlled study to be conducted exclusively in these patients with Cushing’s syndrome. We expect data from GRADIENT in the fourth quarter of this year.”

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Mon, 04 May 2026 06:00:00 EST

(Mon, 04 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Mon, 04 May 2026 07:00:00 EST

(Mon, 04 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Thymic Neuroendocrine Tumor With Metastasis to the Breast Causing Ectopic Cushing’s Syndrome

Mon, 04 May 2026 07:00:00 EST

(Mon, 04 May 2026 )

We present a case of a 34-year-old woman with a rapid onset of severe hypercortisolism in April 2016. After initial treatment with a steroid inhibitor (ketoconazole) and diagnostics including 68Ga DOTA-TATE PET/CT, it was shown to be caused by a small thymic NET.

https://cushings.invisionzone.com/topic/57807-thymic-neuroendocrine-tumor-with-metastasis-to-the-breast-causing-ectopic-cushing%E2%80%99s-syndrome/

Sabrina, Undiagnosed Bio

Mon, 04 May 2026 07:00:00 EST

(Mon, 04 May 2026 )

Hii my name is Sabrena and i am only 16 years old,

i realised i had all the symptoms of Cushings disease about a week ago. I started seeing the fact that i am constantly gaining weight, i went to see my doctor and i told her about it i told her i had all the symptoms of CD and i am constantly gaining weight each day i have stretch marks on my abodmen, my arms and back too, my periods dont come for about 3month sometimes more/ or less.

https://cushingsbios.com/2026/05/04/sabrena-sabrena-undiagnosed-bio/

FDA Grants Breakthrough Therapy Designation for Oral Congenital Adrenal Hyperplasia Drug

Mon, 04 May 2026 08:00:00 EST

(Mon, 04 May 2026 )

The FDA granted breakthrough therapy designation for an oral non-glucocorticoid medication for the treatment of congenital adrenal hyperplasia, according to an industry press release.

Crinecerfont (Neurocrine Biosciences) is a selective corticotropin-releasing factor type 1 receptor antagonist under development to lower excess adrenal androgens for people with congenital adrenal hyperplasia due to 21-hyroxylase deficiency.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Mon, 04 May 2026 08:00:00 EST

(Mon, 04 May 2026 )

Basics: The Pituitary Gland: Small But Mighty

Mon, 04 May 2026 09:00:00 EST

(Mon, 04 May 2026 )

“The pituitary is commonly referred to as the ‘master’ gland because it does so many important jobs in the body,” says Karen Frankwich, MD, a board-certified endocrinologist at Mission Hospital. “Not only does the pituitary make its own hormones, but it also triggers hormone production in other glands. The pituitary is aided in its job by the hypothalamus. This part of the brain is situated above the pituitary, and sends messages to the gland on when to release or stimulate production of necessary hormones.”

Complete and Sustained Remission of Hypercortisolism With Pasireotide Treatment of an Adrenocorticotropic Hormone (Acth)-Secreting Thoracic Neuroendocrine Tumour: an N-Of-1 Trial

Mon, 04 May 2026 09:00:00 EST

(Mon, 04 May 2026 )

%MCEPASTEBIN%

Fulminant Ectopic Cushing’s Syndrome Caused by Metastatic Small Intestine Neuroendocrine Tumour

Mon, 04 May 2026 09:00:00 EST

(Mon, 04 May 2026 )

This review is illustrated by the case of a 75-year old woman with fulminant ectopic Cushing's Syndrome caused by a ACTH-secreting metastatic siNET. Severe hypokalemia, fluid retention and refractory hypertension were the presenting symptoms.

Restoration of Intra-patient Variability and Diurnal Range of ACTH with Remission in Cushing’s Disease

Mon, 04 May 2026 10:00:00 EST

(Mon, 04 May 2026 )

The following is a summary of “Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing’s Disease,” published in the November 2023 issue of Endocrinology by Alvarez, et al.

Can you Help? Cyclic Cushing's?

Mon, 04 May 2026 10:00:00 EST

(Mon, 04 May 2026 )

I'm also noticing physical symptoms such as new patches of hair on my back, hyperpigmentation of my knuckles, knee and elbow, high blood pressure, bruises that heal dark as well as the severe nervousness and anxiety. Given my tests and symptoms that are on a cycle, can this be cyclic cushing's?

https://cushings.invisionzone.com/topic/57738-can-i-be-cyclic/

‘Cortisol Face’ Is Real, But It’s Not As Common As You Might Think

Mon, 04 May 2026 10:00:00 EST

(Mon, 04 May 2026 )

High levels of the stress hormone cortisol can cause the face to gradually swell into a rounded shape and is often the result of prolonged use of corticosteroids, Cushing syndrome or other underlying medical issues.

https://cushings.invisionzone.com/topic/57757-%E2%80%98cortisol-face%E2%80%99-is-real-but-it%E2%80%99s-not-as-common-as-you-might-think/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Mon, 04 May 2026 10:00:00 EST

(Mon, 04 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease

Mon, 04 May 2026 11:00:00 EST

(Mon, 04 May 2026 )

Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic exposure to excess cortisol has detrimental effects on health, including increased stroke rates, diabetes, obesity, cognitive impairment, anxiety, depression, and death. The first-line treatment for CD is pituitary surgery. Current surgical remission rates reported in only 56% of patients depending on several criteria. The lack of specificity, poor tolerability, and low efficacy of the subsequent second-line medical therapies make CD a medical therapeutic challenge. One major limitation that hinders the development of specific medical therapies is the lack of relevant human model systems that recapitulate the cellular composition of PitNET microenvironment.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Mon, 04 May 2026 11:00:00 EST

(Mon, 04 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Connecting Canine and Human Health to Fight Cushing’s Disease

Mon, 04 May 2026 11:00:00 EST

(Mon, 04 May 2026 )

Cushing’s Disease is common in dogs but rare and hard to diagnose in people. That’s why University of Georgia researchers are leveraging canine treatments to find new solutions to battle the condition in humans. This collaboration between veterinary medicine and human health care is just one example of how UGA uses a Precision One Health approach to find and tailor new medical treatments for people and animals.

https://cushings.invisionzone.com/topic/57820-connecting-canine-and-human-health-to-fight-cushing%E2%80%99s-disease/

Adrenal Insufficiency Common After Adrenalectomy for Mild Autonomous Cortisol Secretion

Mon, 04 May 2026 11:00:00 EST

(Mon, 04 May 2026 )

More than half of adults who underwent a unilateral adrenalectomy to treat mild autonomous cortisol secretion developed adrenal insufficiency,

https://cushings.invisionzone.com/topic/57891-adrenal-insufficiency-common-after-adrenalectomy-for-mild-autonomous-cortisol-secretion/

📰 Age and Hematologic Parameters Can Predict Prolonged Glucocorticoid Replacement After Remission Of Cushing Disease And Adrenal Cushing’s Syndrome

Mon, 04 May 2026 11:00:00 EST

(Mon, 04 May 2026 )

Older age, and lower baseline neutrophils and NLR, were associated with prolonged postoperative GC replacement. These findings suggest that routine hematologic markers may help predict delayed recovery and guide individualized tapering strategies.

https://cushings.invisionzone.com/topic/57954-%F0%9F%93%B0-age-and-hematologic-parameters-can-predict-prolonged-glucocorticoid-replacement-after-remission-of-cushing-disease-and-adrenal-cushing%E2%80%99s-syndrome/

A Preliminary Model to Tailor Osilodrostat In Patients With Adrenocorticotropic Hormone (ACTH)-Sependent Cushing's syndrome

Mon, 04 May 2026 15:00:00 EST

(Mon, 04 May 2026 )

Over the past 10 years, osilodrostat has become one of the most commonly used steroidogenesis inhibitors in patients with Cushing's syndrome. The starting dose is usually determined based on the product characteristics, the prescriber's experience, and cortisol levels.

https://cushings.invisionzone.com/topic/57890-a-preliminary-model-to-tailor-osilodrostat-in-patients-with-adrenocorticotropic-hormone-acth-dependent-cushings-syndrome/

From a Past Blogging Challenge: Cushing’s Awareness Challenge ~ Danielle, Day 4

Mon, 04 May 2026 16:00:00 EST

(Mon, 04 May 2026 )

I have often said, I wish I had cancer instead. Most people would not understand this sentiment, why in the world would you wish for such a horrible disease?...

What Do You Think? Only One Urine Test for Cushing's?

Mon, 04 May 2026 16:00:00 EST

(Mon, 04 May 2026 )

I sure had way more than one urine test, and lots of blood and more but that was a long time ago. What are your thoughts on this?

Let us know at https://cushings.invisionzone.com/topic/57689-what-do-you-think-only-one-urine-test-for-cushings/

The Impact of Prolonged High-Concentration Cortisol Exposure on Cognitive Function and Risk Factors: Evidence From Cushing's Disease Patients

Mon, 04 May 2026 16:00:00 EST

(Mon, 04 May 2026 )

This study confirms the significant impact of prolonged high cortisol exposure on cognitive function and identifies key risk factors. The nomogram model offers robust performance, providing a valuable tool for managing Cushing's disease patients’ cognitive health and informing strategies for other cortisol-related disorders.

https://cushings.invisionzone.com/topic/57821-the-impact-of-prolonged-high-concentration-cortisol-exposure-on-cognitive-function-and-risk-factors-evidence-from-cushings-disease-patients/

Cushing’s Syndrome: A New Drug Allows You To Avoid Surgery

Mon, 04 May 2026 17:00:00 EST

(Mon, 04 May 2026 )

The Cushing’s syndrome, a disease caused by the excessive production of cortisol by the pituitary gland due to a benign tumor of the gland, has seen a breakthrough in its treatment. Thanks to a new drug called osilodrostat, approved in 2020 by the Food and Drug Administration and subsequently by Aifa in Italy, patients unfit for surgery can benefit from a treatment that offers the same effects as a scalpel. Furthermore, this drug reduced symptoms in 80% of cases.

Tips from Message Board Members

Mon, 04 May 2026 17:00:00 EST

(Mon, 04 May 2026 )

I have learned so much on this Cushing’s journey, much of it from all of you and this site. I wanted to share those learnings, in the event that it helps anyone else.

Obviously – my own opinions here!

My best wishes to everyone on their Cushing’s journey.

https://cushings-help.com/2024/11/04/tips-from-message-board-members/

Add or update Your Bio

Tue, 05 May 2026 01:00:00 EST

(Tue, 05 May 2026 )

Please add your bio. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2024/10/28/we-have-a-new-bio-form/

Cushing's World Map

Tue, 05 May 2026 01:00:00 EST

(Tue, 05 May 2026 )

Add your location and diagnosis to our Cushing's World Map.
Helpful Doctor locations are being added to this map, as well

See the Map at https://drive.google.com/open?id=1NLdGqTJyaJOvxegUnUR_slLRcYyMsVbJ&usp=sharing

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Tue, 05 May 2026 03:00:00 EST

(Tue, 05 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Basics: Meds - Isturisa

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

Cushing’s disease is a progressive pituitary disorder in which there is an excess of cortisol in the body. While the disease can be treated surgically, this option is not possible for all patients. This is one of the approved medications that assist in controlling cortisol levels in people with Cushing’s disease.

Isturisa was approved in 2020 to treat adults with Cushing’s disease for whom pituitary surgery is ineffective or not an option.

Investigating the Frequency of Active Adrenal Incidentalomas

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

For a study, researchers sought to ascertain the prevalence of various forms of autonomous hormone secretion in individuals diagnosed with adrenal incidentaloma, including autonomous/possible autonomous cortisol secretion (ACS), primary aldosteronism (PA), pheochromocytoma (PHEO), and Cushing syndrome (CS).

Investigating the Frequency of Active Adrenal Incidentalomas

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

Talus Avascular Necrosis as a Rare Complication of Cushing’s Disease

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

We report a middle-aged woman with Cushing’s syndrome symptoms, such as hypertension and moon face, since her youth. A few years ago, she experienced pain and swelling in her ankle, which was diagnosed as atraumatic AVNT and treated with hindfoot fusion. Years later, she was diagnosed with Cushing’s disease caused by an adrenocorticotropic hormone (ACTH)-producing pituitary adenoma in laboratory tests and imaging, which was resected in 2020.

Hannah C, Video Bio

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

Hannah Cadwallader, 34, went 10 years without answers before learning she had Cushing’s disease, a form of Cushing’s syndrome, caused by a pituitary tumour that triggers the overproduction of the hormone cortisol.

https://cushingsbios.com/2026/05/05/hannah-c-video-bio/

Mary (TheGoat), Pituitary Bio

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

I had 3 transphenoidal surgeries 1 month apart in 2003. I had a csf leak and when it was repaired the pituitary had become necrotic and I lost the whole gland.

They said that did not cure the cushings so I had a BLA in 2004.

https://cushingsbios.com/2026/05/04/mary-thegoat-pituitary-bio/

Vynn, Pituitary Bio

Tue, 05 May 2026 04:00:00 EST

(Tue, 05 May 2026 )

Have had 8 grueling months of tests and could have done with support as I was quite confused. Nothing in Australia. Tried internet but didnt see this site.

https://cushingsbios.com/2026/05/04/vynn-w-pituitary-bio/

We Thought Dad Would Be Alright But We Were Wrong

Tue, 05 May 2026 05:00:00 EST

(Tue, 05 May 2026 )

A loving dad with ‘boundless energy and positivity’ died unexpectedly of a rare condition. Dave Whitfield was 59 when he died in December 2023.

His son Archie, 23, explained that his dad had been diagnosed with several brain tumours throughout his life but they had always been treatable by doctors. This changed in early 2023 however.

Another brain tumour led to Dave being diagnosed with Cushing’s syndrome, a rare condition caused by excessive cortisol in the body. Often this overproduction is due to a benign tumour in the pituitary or adrenal glands.

Cortisol helps the body cope with stressful situations, as well as reducing swelling and fighting off infections. Cushing’s syndrome is also much more common in women than in men.

Because of this, Archie and the wider family were taken aback about what happened to Dave. Speaking to the ECHO, Archie said: “Dad had brain tumours come and go over the last 15, 20 years.

“He was always able to either get the tumour operated on or have radiotherapy to have them removed. However, a couple years ago, a tumour came back, causing Cushing's syndrome.

https://cushingsbios.com/2025/04/05/pituitary-we-thought-dad-would-be-alright-but-we-were-wrong/

A Positive Corticotropin-Releasing Hormone Test May Obviate the Need For Petrosal Sinus Sampling in Patients With Cushing’s Disease

Tue, 05 May 2026 05:00:00 EST

(Tue, 05 May 2026 )

Bilateral inferior petrosal sinus sampling (BIPSS) is considered the most accurate procedure to confirm the diagnosis of Cushing’s disease (CD). However, it is a cumbersome and costly procedure. We aim to determine whether the corticotropin-releasing hormone (CRH) test alone might differentiate CD from ectopic adrenocorticotropin (ACTH) syndrome (EAS).

https://cushings.invisionzone.com/topic/57955-a-positive-corticotropin-releasing-hormone-test-may-obviate-the-need-for-petrosal-sinus-sampling-in-patients-with-cushing%E2%80%99s-disease/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Tue, 05 May 2026 06:00:00 EST

(Tue, 05 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Metyrapone Benefits Blood Pressure in Mild Hypercortisolism

Tue, 05 May 2026 06:00:00 EST

(Tue, 05 May 2026 )

A notable proportion of patients with mild hypercortisolism achieved blood pressure (BP) control with low-dose evening metyrapone, without requiring the intensification of antihypertensive therapy. The treatment was particularly beneficial for those with higher baseline systolic BP and was well tolerated, with no adverse events reported.

https://cushings.invisionzone.com/topic/57908-metyrapone-benefits-blood-pressure-in-mild-hypercortisolism/

Tips from Message Board Members

Tue, 05 May 2026 06:00:00 EST

(Tue, 05 May 2026 )

Things I’ve learned and wanted to share

From Cushing’s Message Board members. This is a continuing list, if you want to share.

I have learned so much on this Cushing’s journey, much of it from all of you and this site. I wanted to share those learnings, in the event that it helps anyone else....

https://cushings-help.com/2025/11/04/tips-from-message-board-members/

Basics: Testing: What Is a TSH Test?

Tue, 05 May 2026 07:00:00 EST

(Tue, 05 May 2026 )

TSH stands for “thyroid stimulating hormone” and the test measures how much of this hormone is in your blood. TSH is produced by the pituitary gland in your brain. This gland tells your thyroid to make and release the thyroid hormones into your blood.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Tue, 05 May 2026 07:00:00 EST

(Tue, 05 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Dr. Friedman Has Partnered With Ulta Lab Tests to Offer Affordable, Hassle-Free Lab Testing at About One-Tenth the Cost of Going Through Insurance

Tue, 05 May 2026 07:00:00 EST

(Tue, 05 May 2026 )

Dr. Friedman understands your concerns and has partnered with Ulta Lab Tests to offer affordable, hassle-free lab testing—typically at about one-tenth the cost of going through insurance, with fast turnaround times.

https://cushings.invisionzone.com/topic/57935-dr-friedman-has-partnered-with-ulta-lab-tests-to-offer-affordable-hassle-free-lab-testing-at-about-one-tenth-the-cost-of-going-through-insurance/

“I don’t Feel Normal” – The Diagnosis of a Pituitary Tumor & Cushing’s Disease

Tue, 05 May 2026 08:00:00 EST

(Tue, 05 May 2026 )

When Lydia first met with her OBGYN to address her weight gain and the overall feeling that something was wrong with her body, her concerns were quickly dismissed. “He told me ‘You’re almost 30 and you’ve had two kids, no wonder you feel the way that you do,’” said Lydia. “He blew me off and told me that I needed more diet and exercise. He didn’t order other tests.”

Long-Term Efficacy and Safety of Osilodrostat in Patients with Cushing’s Disease

Tue, 05 May 2026 09:00:00 EST

(Tue, 05 May 2026 )

Osilodrostat provided long-term control of cortisol secretion that was associated with sustained improvements in clinical signs and physical manifestations of hypercortisolism. Osilodrostat is an effective long-term treatment for patients with Cushing’s disease.

Levoketoconazole Treatment in Endogenous Cushing’s Syndrome

Tue, 05 May 2026 10:00:00 EST

(Tue, 05 May 2026 )

This extended evaluation (EE) of the SONICS study assessed effects of levoketoconazole for an additional 6 months following open-label, 6-month maintenance treatment in endogenous Cushing’s syndrome.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Tue, 05 May 2026 10:00:00 EST

(Tue, 05 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Tue, 05 May 2026 11:00:00 EST

(Tue, 05 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

From a Past Blogging Challenge: Cushing’s Awareness Challenge ~ Danielle, Day 5

Tue, 05 May 2026 15:00:00 EST

(Tue, 05 May 2026 )

Social media dominates most people's lives these days. You see what everyone you know is up to, but the problem is, most people only post about the highlights of their lives.

You don't get to see the low points, the every day struggles. You don't see what keeps them up at night with worry...

Basics: Workup for Incidental Pituitary Adenoma

Tue, 05 May 2026 16:00:00 EST

(Tue, 05 May 2026 )

A 35-year-old woman is seen in the outpatient clinic for evaluation of an incidental pituitary macroadenoma. Her medical history is significant for hypertension, diabetes, hyperlipidemia, polycystic ovary syndrome, and obesity. She initially presented to the emergency department (ED) a week ago after an episode of right visual field changes that she described as waviness in her right eye and right hemibody sensory changes without motor deficits. While in the ED, she underwent a full workup for possible stroke, which was negative. Magnetic resonance imaging (MRI) of her brain without contrast revealed a 12-mm pituitary lesion; a repeat MRI with contrast was then ordered (Figure). No serum hormonal panel was available for review from ED records.

Older Adults With Cushing’s Disease Present With Fewer Symptoms Than Younger Patients

Tue, 05 May 2026 17:00:00 EST

(Tue, 05 May 2026 )

The presentation of Cushing’s disease varies by age, with older adults having fewer hallmark features of the condition and more comorbidities, according to study findings published in The Journal of Clinical Endocrinology & Metabolism.

https://cushings.invisionzone.com/topic/57790-older-adults-with-cushing%E2%80%99s-disease-present-with-fewer-symptoms-than-younger-patients/

The Impact of Adrenalectomy On Metabolic Outcomes of Patients Wwth Mild Autonomous Cortisol Secretion Defined by Low-Dose Dexamethasone Suppression Testing

Tue, 05 May 2026 18:00:00 EST

(Tue, 05 May 2026 )

Weight loss should be considered as a potential benefit of adrenalectomy in patients with mild autonomous cortisol secretion.

https://cushings.invisionzone.com/topic/57892-the-impact-of-adrenalectomy-on-metabolic-outcomes-of-patients-wwth-mild-autonomous-cortisol-secretion-defined-by-low-dose-dexamethasone-suppression-testing/

Interview Archive with Judy, mom to 2 Cushing’s Patients, and her daughter Jess

Tue, 05 May 2026 21:00:00 EST

(Tue, 05 May 2026 )

Interview with Judy, the mother of two Cushing’s patients, and her daughter, Jess, a high school student with Cushing’s. Robin (staticnrg) hosted.

Secondary Adrenal Insufficiency and Iatrogenic Cushing's Syndrome in a 13-Year-Old Male With Vogt-Koyanagi-Harada Disease

Wed, 06 May 2026 01:00:00 EST

(Wed, 06 May 2026 )

We report a 13-year-old male with VKH who developed iatrogenic Cushing’s syndrome and secondary adrenal insufficiency after prolonged prednisone treatment. Despite adding mycophenolate mofetil, tapering failed due to relapses. He showed weight gain, growth delay, striae, and suppressed cortisol and adrenocorticotropic hormone, confirming hypothalamic-pituitary-adrenal axis suppression.

https://cushings.invisionzone.com/topic/57909-secondary-adrenal-insufficiency-and-iatrogenic-cushings-syndrome-in-a-13-year-old-male-with-vogt-koyanagi-harada-disease/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Wed, 06 May 2026 03:00:00 EST

(Wed, 06 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

A Challenging Diagnosis of Cushing’s Syndrome in Primary Care: A Case Report

Wed, 06 May 2026 04:00:00 EST

(Wed, 06 May 2026 )

Cushing’s syndrome is a rare endocrine disorder characterized by an insidious course and multisystem manifestations, often leading to delayed diagnosis due to its nonspecific presentation. A 52-year-old woman with a history of type 2 diabetes mellitus and hypertension was followed in primary care for persistent musculoskeletal pain and worsening metabolic control, initially attributed to poor treatment adherence. Her condition progressively led to significant functional impairment, requiring the use of crutches for ambulation and ultimately resulting in medical retirement due to disability. After presenting with abdominal pain, a computed tomography scan incidentally revealed a 35 mm left adrenal mass suggestive of an adenoma. In light of the clinical context, further evaluation confirmed adrenocorticotropic hormone (ACTH)-independent hypercortisolism. The patient underwent left adrenalectomy and remains under clinical follow-up, with progressive improvement in metabolic parameters and functional status.

This case highlights the importance of reassessing persistent symptoms and appropriately evaluating incidental findings in primary care, as well as the potential for significant functional decline in undiagnosed cases. Early recognition of atypical presentations may facilitate the diagnosis of rare endocrine disorders.

https://cushings.invisionzone.com/topic/57956-a-challenging-diagnosis-of-cushing%E2%80%99s-syndrome-in-primary-care-a-case-report/

Dee (Dee), Pituitary Bio

Wed, 06 May 2026 05:00:00 EST

(Wed, 06 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

A few years passed and my blood pressure sky rocketed, my hair started falling out, my teeth were breaking and I was gaining weight and unable to stop it. I grew a heavy beard, black hairs on my arms and thighs. My face became distored, my head was pushed towards my feet from a hump on my back. I was losing the use of my legs, and unable to hold a pen or pencil. I started to look 7 months pregnant with a larged mid-section. I couldn’t retain simple instructions, and had to stop driving...

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Wed, 06 May 2026 06:00:00 EST

(Wed, 06 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Navigating the Surgical Landscape: A Comprehensive Analysis of Endoscopic vs. Microscopic Transsphenoidal Pituitary Surgery Outcomes

Wed, 06 May 2026 06:00:00 EST

(Wed, 06 May 2026 )

Pituitary surgery, a critical intervention for various pituitary disorders, has sparked ongoing debates regarding the preference between endoscopic and microscopic transsphenoidal approaches. This systematic review delves into the outcomes associated with these techniques, taking into account the recent advancements in neurosurgery.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Wed, 06 May 2026 07:00:00 EST

(Wed, 06 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Cushing’s Syndrome caused by ACTH Precursors Secreted from a Pancreatic Yolk Sac Tumor in an Adult

Wed, 06 May 2026 07:00:00 EST

(Wed, 06 May 2026 )

A 27-year-old Chinese woman, who had unremarkable past health and family history, presented with right upper quadrant abdominal pain and nausea in early 2020. Abdominal ultrasonography was unrevealing. A few months later, she developed Cushingoid features and oligomenorrhea.

Cushing’s Myths and Facts: “Each Person Requires the Same Dose of Steroid in Order to Survive…”

Wed, 06 May 2026 09:00:00 EST

(Wed, 06 May 2026 )

Fact: In simple terms, Adrenal Insufficiency occurs when the body does not have enough cortisol in it. You see, cortisol is life sustaining and we actually do need cortisol to survive. You have probably seen the commercials about “getting rid of extra belly fat” by lowering your cortisol. These advertisements make it hard for people to actually understand the importance of the function of cortisol....

Tips for Living with Cushing’s

Wed, 06 May 2026 09:00:00 EST

(Wed, 06 May 2026 )

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Behind High Blood Pressure and Anxiety, a Hidden Diagnosis: The Overlooked Rise of Adrenal Disorders

Wed, 06 May 2026 09:00:00 EST

(Wed, 06 May 2026 )

April marks Adrenal Awareness Month, a national initiative focused on a group of hormonal disorders that are frequently overlooked, often misdiagnosed, and in some cases life-threatening if left untreated. Many adrenal disorders present with symptoms that mimic common conditions—such as high blood pressure, anxiety, weight gain, or fatigue—leading patients to go undiagnosed for years.

Adrenal Awareness Month expands its focus to spotlight a broader range of adrenal disorders, including Cushing’s syndrome, pheochromocytoma, Conn’s syndrome, and adrenal cancer. Each condition will be featured throughout the month, offering targeted education, resources, and increased visibility for these complex and often overlooked diseases.

https://cushings.invisionzone.com/topic/57950-behind-high-blood-pressure-and-anxiety-a-hidden-diagnosis-the-overlooked-rise-of-adrenal-disorders/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Wed, 06 May 2026 10:00:00 EST

(Wed, 06 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Millennial Woman Hasn’t Slept the Night in 19 Months—Viewers Shocked Why

Wed, 06 May 2026 10:00:00 EST

(Wed, 06 May 2026 )

Adrenal hormones: Excess can lead to Cushing’s disease, characterized by a moon-shaped face, excess body hair, easy bruising, menstrual irregularities and high blood pressure.

https://cushings.invisionzone.com/topic/57893-newsweek-article-millennial-woman-hasn%E2%80%99t-slept-the-night-in-19-months%E2%80%94viewers-shocked-why/

Personalized Noninvasive Diagnostic Algorithms Based on Urinary Free Cortisol in ACTH-dependant Cushing’s Syndrome

Wed, 06 May 2026 11:00:00 EST

(Wed, 06 May 2026 )

Current guidelines for distinguishing Cushing's disease (CD) from ectopic ACTH secretion (EAS) are questionable, as they use pituitary magnetic resonance imaging (MRI) as first-line investigation for all patients. CRH testing is no longer available, and they suggest performing inferior petrosal sinus sampling (BIPPS), an invasive and rarely available investigation, in many patients.

https://cushings.invisionzone.com/topic/57765-personalized-noninvasive-diagnostic-algorithms-based-on-urinary-free-cortisol-in-acth-dependant-cushing%E2%80%99s-syndrome/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Wed, 06 May 2026 11:00:00 EST

(Wed, 06 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Cushing Syndrome Leaves Lasting Health Effects

Wed, 06 May 2026 15:00:00 EST

(Wed, 06 May 2026 )

Compared with a matched population-based control group, patients with Cushing syndrome continued to exhibit elevated systolic and diastolic blood pressures along with reduced kidney function at least 14 years after biochemical remission.

https://cushings.invisionzone.com/topic/57860-cushing-syndrome-leaves-lasting-health-effects/

In Memory of Gregory J. Bart Jr. ~ May 7, 2016

Thu, 07 May 2026 01:00:00 EST

(Thu, 07 May 2026 )

He died of a presumed heart attack.

September 19, 2015 he said ''I was diagnosed hypertensive way back when I was 20. The condition remained for years, and became more acute with my cushings pit tumor. I still have high blood pressure, partially teated with three meds. I'll have to consult my doc and see if this may also be an issue.'

More information at https://cushingsbios.com/2022/05/07/in-memory-of-gregory-j-bart-jr-may-7-2016-2/

Tracking a Mystery Disease to the Pituitary Gland

Thu, 07 May 2026 03:00:00 EST

(Thu, 07 May 2026 )

Sharmyn McGraw knows as much about pituitary disease as some doctors. She learned about it after struggling for years with a medical mystery that began in 1993.

First, she began to feel anxious. Then, she began to gain weight, and she developed a rash. Much of her hair fell out. Her eyes began to yellow and her face puffed up.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Thu, 07 May 2026 03:00:00 EST

(Thu, 07 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Iatrogenic Cushing’s Syndrome and the Hidden Ingredient of Artri King

Thu, 07 May 2026 04:00:00 EST

(Thu, 07 May 2026 )

We present a case of a 52-year-old man with osteoporosis who sustained fragility fractures and became wheelchair-bound due to progressive lower extremity weakness. Evaluation demonstrated suppression of the hypothalamic-pituitary-adrenal axis, with undetectable salivary and urinary cortisol levels. Further investigation revealed long-term use of Artri King, a supplement for musculoskeletal pain that contains undisclosed glucocorticoids. This case highlights the risk of unregulated supplements causing iatrogenic Cushing’s syndrome and its associated complications.

https://cushings.invisionzone.com/topic/57936-iatrogenic-cushing%E2%80%99s-syndrome-and-the-hidden-ingredient-of-artri-king/

Reversibility of Impaired Large-Scale Functional Brain Networks in Cushing’s Disease after Surgery Treatment: A Longitudinal Study

Thu, 07 May 2026 05:00:00 EST

(Thu, 07 May 2026 )

Chronic exposure to excessive endogenous cortisol leads to brain changes in Cushing’s disease (CD). However, it remains unclear how CD affects large-scale functional networks (FNs) and whether these effects are reversible after treatment. This study aimed to investigate functional network changes of CD patients and their reversibility in a longitudinal cohort.

Iatrogenic Cushing Syndrome and Adrenal Suppression Presenting as Perimenopause

Thu, 07 May 2026 05:00:00 EST

(Thu, 07 May 2026 )

Secondary adrenal insufficiency is a life-threatening condition that may arise in the setting of iatrogenic Cushing syndrome. Intra-articular corticosteroid injections (IACs) are a standard treatment for osteoarthritis, and they carry a high risk of secondary central adrenal suppression (SAI).

https://cushings.invisionzone.com/topic/57766-iatrogenic-cushing-syndrome-and-adrenal-suppression-presenting-as-perimenopause/

From Weight Gain To Diabetes—Endocrinologist Shares Signs That Indicate You Have Cushing’s Syndrome

Thu, 07 May 2026 05:00:00 EST

(Thu, 07 May 2026 )

Cushing’s syndrome happens when the body has too much cortisol, the stress hormone. It can cause weight gain, high blood pressure, and diabetes. So how to keep your health in check and what are the treatment options available? In an exclusive interview with Times Now, an Endocrinologist explains its symptoms, causes, and treatments.

https://cushings.invisionzone.com/topic/57791-from-weight-gain-to-diabetes%E2%80%94endocrinologist-shares-signs-that-indicate-you-have-cushing%E2%80%99s-syndrome/

Ultrasound-Guided Jugular Vein Access for Inferior Petrosal Sinus Sampling: A Safe and Feasible Technique

Thu, 07 May 2026 05:00:00 EST

(Thu, 07 May 2026 )

A woman with poorly controlled diabetes, obesity, chronic kidney disease (CKD), and hypertension presented with suspected Cushing’s syndrome. Despite normal urinary free cortisol (UFC) levels (likely influenced by renal dysfunction), clinical suspicion prompted further testing, which revealed an inverted cortisol rhythm and lack of suppression on low-dose dexamethasone. High-dose suppression indicated a pituitary source. MRI findings were inconclusive. To confirm the diagnosis, bilateral IPSS was attempted. Right petrosal sinus catheterization via femoral access was successful; however, left-sided access failed. An alternative, ultrasound-guided direct left internal jugular puncture was performed, allowing complete sampling.

https://cushings.invisionzone.com/topic/57926-ultrasound-guided-jugular-vein-access-for-inferior-petrosal-sinus-sampling-a-safe-and-feasible-technique/

Suggesting Cushing’s to Others

Thu, 07 May 2026 05:00:00 EST

(Thu, 07 May 2026 )

Some early responses from Facebook:
Would you tell a stranger they might have Cushing’s?

Yes!!!

I did…and it did not go over well. I recommended two ladies see an endo because they were obviously cushie. Both thought I was nuts and didn’t listen to me (that I know of.) One was a patient of my GI and she told me all her symptoms and it was classic Cushing’s-and she didn’t believe me. She told the doc I was nuts. I don’t know if I helped or hindered their quest for a diagnosis. It makes me think twice if I see someone that might have Cushing’s.

Well...

https://cushieblog.com/2025/12/06/suggesting-cushings-to-others/

Dee (Dee), Pituitary Bio

Thu, 07 May 2026 05:00:00 EST

(Thu, 07 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Thu, 07 May 2026 06:00:00 EST

(Thu, 07 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Thu, 07 May 2026 07:00:00 EST

(Thu, 07 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

A Patient With a Bronchial Carcinoid Presents With Cushingoid Symptoms Due To An Atypical and Potentially Dangerous Supplement

Thu, 07 May 2026 08:00:00 EST

(Thu, 07 May 2026 )

The most common cause of ectopic ACTH syndrome is pulmonary carcinoid tumors and squamous cell lung cancer; however it is a relatively uncommon complication of pulmonary neoplasms.

The most common cause of Cushing syndrome is iatrogenic corticosteroid use and it should be considered in all patients regardless of clinical background.
Low urine cortisol levels may be associated with exogenous glucocorticoid exposure.
Occult glucocorticoid exposure is rare but can be evaluated with liquid chromatography.
Consumers should be aware of the potential risks of taking supplements, especially those advertised as joint pain relief products.

Cushing Syndrome Caused by an Ectopic ACTH-Producing Pituitary Adenoma of the Clivus Region

Thu, 07 May 2026 09:00:00 EST

(Thu, 07 May 2026 )

Ectopic ACTH-producing pituitary adenoma (EAPA) of the clivus region is extraordinarily infrequent condition and merely a few reports have been reported to date.

The patient was a 53-year-old woman who presented with Cushing-like appearances and a soft tissue mass in the clivus region.

Paraneoplastic Cushing's Syndrome Due to ACTH-Secreting Acinic Cell Carcinoma of the Parotid Gland: A Rare Case

Thu, 07 May 2026 09:00:00 EST

(Thu, 07 May 2026 )

Although acinic cell carcinoma — a cancer of the glands that produce saliva — is usually considered low risk, it can behave aggressively and cause Cushing’s syndrome, according to researchers who described such a case involving a 58-year-old man in Turkey.

They added that if not recognized and treated at an early stage, it can rapidly become life-threatening.

https://cushings.invisionzone.com/topic/57938-paraneoplastic-cushings-syndrome-due-to-acth-secreting-acinic-cell-carcinoma-of-the-parotid-gland-a-rare-case/

Merck Manuals: Answering Common Questions About Cushing Syndrome

Thu, 07 May 2026 10:00:00 EST

(Thu, 07 May 2026 )

High cortisol – and its deleterious effects on the body – may be a more commonly recognized phrase in today's healthcare lexicon. Still, doctors say there is a need for more awareness of a rare and potentially life-threatening condition involving cortisol, known as Cushing's Syndrome

https://cushings.invisionzone.com/topic/57808-merck-manuals-answering-common-questions-about-cushing-syndrome/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Thu, 07 May 2026 10:00:00 EST

(Thu, 07 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Cushing’s Disease: When Symptoms Are Mistaken for Menopause

Thu, 07 May 2026 10:00:00 EST

(Thu, 07 May 2026 )

After 8 years of menopause-like symptoms, a 62 year old patient discovered she actually had Cushing’s disease. Read about her long journey to get a diagnosis and her success in finding her dream-come-true neurosurgeon.

https://cushings.invisionzone.com/topic/57939-cushing%E2%80%99s-disease-when-symptoms-are-mistaken-for-menopause/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Thu, 07 May 2026 11:00:00 EST

(Thu, 07 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Osilodrostat Treatment for Adrenal and Ectopic Cushing Syndrome

Thu, 07 May 2026 11:00:00 EST

(Thu, 07 May 2026 )

Although most cases of endogenous Cushing syndrome are caused by a pituitary adenoma (Cushing disease), approximately one-third of patients present with ectopic or adrenal causes.

Surgery is the first-line treatment for most patients with Cushing syndrome; however, medical therapy is an important management option for those who are not eligible for, refuse, or do not respond to surgery.

https://cushings.invisionzone.com/topic/57823-osilodrostat-treatment-for-adrenal-and-ectopic-cushing-syndrome/

Survival Probabilities in Patients with Ectopic Cushing’s Syndrome

Thu, 07 May 2026 11:00:00 EST

(Thu, 07 May 2026 )

Survival in Ectopic Cushing’s Syndrome varies considerably, mainly due to the underlying origin of the tumor, tumor stage and severity of the hypercortisolism. Further studies analyzing the importance of factors affecting survival are needed.

https://cushings.invisionzone.com/topic/57838-survival-probabilities-in-patients-with-ectopic-cushing%E2%80%99s-syndrome/

Therapeutic Options for the Prevention of Thromboses in Cushing’s Syndrome

Fri, 08 May 2026 01:00:00 EST

(Fri, 08 May 2026 )

Although low-molecular weight heparin (LMWH) is currently recommended as the gold standard for anticoagulation in patients with hypercortisolism, our evidence suggests that low-dose antiplatelets such as aspirin 81 mg could outperform it.

https://cushings.invisionzone.com/topic/57842-therapeutic-options-for-the-prevention-of-thromboses-in-cushing%E2%80%99s-syndrome/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Fri, 08 May 2026 03:00:00 EST

(Fri, 08 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Is Cushing Syndrome More Common in the US Than We Think?

Fri, 08 May 2026 05:00:00 EST

(Fri, 08 May 2026 )

'Cases are absolutely being missed…. Clinicians should realize that cortisol excess is not rare. It may not be common, but it needs to be considered in patients with any constellation of features that are seen in cortisol excess,' study investigator Ty B. Carroll, MD, Associate Professor of Medicine, Endocrinology and Molecular Medicine, and the Endocrine Fellowship Program Director at Medical College of Wisconsin in Milwaukee, told Medscape Medical News.

From https://cushings.invisionzone.com/topic/57737-is-cushing-syndrome-more-common-in-the-us-than-we-think/

Dee (Dee), Pituitary Bio

Fri, 08 May 2026 05:00:00 EST

(Fri, 08 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Fri, 08 May 2026 06:00:00 EST

(Fri, 08 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Comment added to Pauline, Undiagnosed Bio

Fri, 08 May 2026 06:00:00 EST

(Fri, 08 May 2026 )

Hi I can relate to what you shared. I have hump on back of my neck. I am hairy and have other symptoms of Cushing's. I have b12 injections every 3 months…

Interview With an Endocrinologist

Fri, 08 May 2026 06:00:00 EST

(Fri, 08 May 2026 )

“Cushing’s Syndrome can be life-threatening if left untreated, but early diagnosis and proper management can significantly improve quality of life. So if you experience unexplained weight gain, blood pressure spikes, or other symptoms, consult an endocrinologist to manage hormonal imbalances,” he said.

https://cushings-help.com/2025/03/07/interview-with-an-endo/

Avascular Necrosis in Patients With Cushing Syndrome

Fri, 08 May 2026 06:00:00 EST

(Fri, 08 May 2026 )

We describe a case of a 71-year-old male with florid Cushing disease who initially presented with bilateral hip AVN and later developed bilateral shoulder Avascular Necrosis despite achieving biochemical remission following transsphenoidal surgery and adjuvant stereotactic photon radiosurgery. AVN in endogenous CS is underreported, and guidance on routine screening is lacking.

https://cushings.invisionzone.com/topic/57792-avascular-necrosis-in-patients-with-cushing-syndrome/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Fri, 08 May 2026 07:00:00 EST

(Fri, 08 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Chronic Insomnia Can Be Sign of Cushing’s

Fri, 08 May 2026 08:00:00 EST

(Fri, 08 May 2026 )

Chronic insomnia can be a sign of Cushing’s syndrome, and doctors need be aware of this possibility, according to a case report of a woman diagnosed with Cushing’s shortly after seeking help for her insomnia.

This case also emphasized the usefulness of the dexamethasone suppression test in identifying the specific cause of Cushing’s.

Diagnostic Dilemma in Cushing’s Syndrome: Discrepancy Between Patient-Reported And Physician-Assessed Manifestations

Fri, 08 May 2026 08:00:00 EST

(Fri, 08 May 2026 )

Early diagnosis and immediate treatment of Cushing’s syndrome (CS) are critical for a better prognosis but remain a challenge. However, few comprehensive reports have focused on this issue or investigated whether patient-reported manifestations are consistent with physician-assessed symptoms of CS. This study aimed to clarify the differences in patient-reported and physician-assessed manifestations of signs and symptoms of CS that prevent early diagnosis.

Minimizing the Number of False Positives in Dexamethasone Suppression Testing for the Diagnosis of Cushing’s Syndrome

Fri, 08 May 2026 09:00:00 EST

(Fri, 08 May 2026 )

A method for diagnosing Cushing's syndrome efficiently and accurately. The approach involves simultaneous the measurement of cortisol and dexamethasone levels using LC-MS/MS, which reduces false positives in dexamethasone suppression test (DSTs). The described LC-MS/MS method enables the tracking of multiple analytes, including cortisol, cortisone, and dexamethasone, in serum or plasma…

A Case of an Ectopic ACTH-Producing Tumor With Adrenal Shrinkage During Osilodrostat Administration

Fri, 08 May 2026 09:00:00 EST

(Fri, 08 May 2026 )

The case involves a 68-year-old man diagnosed with small cell lung cancer and ectopic ACTH-producing Cushing syndrome. Initially, metyrapone was administered to manage hypercortisolism, but its effect proved insufficient. Subsequently, osilodrostat was initiated while gradually decreasing metyrapone, leading to full suppression of blood cortisol levels. With continued osilodrostat treatment, the adrenal glands reduced in size, suggesting the potential to reduce the osilodrostat dosage.

How To Tell if You Have “Cortisol Face” And What to Do About It

Fri, 08 May 2026 09:00:00 EST

(Fri, 08 May 2026 )

The biology behind cortisol face is real. A rough week probably is not causing it. But if changes persist and stack up alongside other symptoms, it is worth taking seriously.

https://cushings.invisionzone.com/topic/57951-how-to-tell-if-you-have-%E2%80%9Ccortisol-face%E2%80%9D-and-what-to-do-about-it/

Urinary free cortisol analyses: Enhancing their clinical performance in Cushing's syndrome management by means of LC-MS/MS

Fri, 08 May 2026 09:00:00 EST

(Fri, 08 May 2026 )

24 h urinary free cortisol (UFC) analysis constitutes one of the three first level recommended tests in Cushing's syndrome (CS) diagnostic confirmation work up. However, it occasionally leads to inaccurate results due to the use of immunoassays (IAs) or the concomitant administration of exogenous glucocorticoids, among others.

https://cushings.invisionzone.com/topic/57952-urinary-free-cortisol-analyses-enhancing-their-clinical-performance-in-cushings-syndrome-management-by-means-of-lc-msms/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Fri, 08 May 2026 10:00:00 EST

(Fri, 08 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Sleep Disturbances in Patients With Cushing Syndrome and Mild Autonomous Cortisol SecretionPatients with mild autonomous cortisol secretion (MACS) demonstrate sleep impairment that is similar to patients with Cushing's Syndrome. Younger women with higher clinical severity of MACS are more likely to have impaired sleep.

Fri, 08 May 2026 10:00:00 EST

(Fri, 08 May 2026 )

Patients with mild autonomous cortisol secretion (MACS) demonstrate sleep impairment that is similar to patients with Cushing's Syndrome. Younger women with higher clinical severity of MACS are more likely to have impaired sleep.

https://cushings.invisionzone.com/topic/57895-sleep-disturbances-in-patients-with-cushing-syndrome-and-mild-autonomous-cortisol-secretion/

Myths and Facts about Cushing’s: Cushing’s Syndrome/Disease can be healed or cured

Fri, 08 May 2026 11:00:00 EST

(Fri, 08 May 2026 )

Fact: NO! Caloric intake or lack of exercise has NO impact on weight gain and/ or loss in persons with Cushing’s...

SPECIAL Archived Cushing’s Awareness Day Voice Chat!

Fri, 08 May 2026 11:00:00 EST

(Fri, 08 May 2026 )

Listen as Jayne Kerns and Robin Smith (staticnrg) hosted a Cushing’s Awareness Day Special Chat.

Multiple Clinical Indications of Mifepristone: A Systematic Review

Fri, 08 May 2026 11:00:00 EST

(Fri, 08 May 2026 )

Mifepristone has also been shown to improve treatment course in patients with Cushing’s disease (CD) who failed or are unable to undergo surgical treatment. In addition, mifepristone has been shown to be a successful treatment option for adenomyosis and leiomyomas.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Fri, 08 May 2026 11:00:00 EST

(Fri, 08 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

In Memory of Melinda Smith ~ May 9, 2014

Sat, 09 May 2026 01:00:00 EST

(Sat, 09 May 2026 )

Sadly, we lost another Cushing’s patient on Friday, May 9, 2014. Melinda was a member of the Cushing’s Help message boards since Jun 24, 2007.

She was only 25 and left behind a young son and many loving family members.

Long-Term Efficacy and Safety of Subcutaneous Pasireotide Alone or In Combination With Cabergoline in Cushing’s Disease

Sat, 09 May 2026 03:00:00 EST

(Sat, 09 May 2026 )

Addition of cabergoline in patients with persistently elevated mUFC on maximum tolerated doses of pasireotide is an effective and well-tolerated long-term strategy for enhancing control of hypercortisolism in some CD patients.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sat, 09 May 2026 03:00:00 EST

(Sat, 09 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Cushing's Basics: Family Information / Kate

Sat, 09 May 2026 04:00:00 EST

(Sat, 09 May 2026 )

Dear friends and family:

I am writing this letter to share with you some basic facts about Cushing’s Disease/Syndrome and the recovery process so that you will have sufficient information to form realistic expectations about me and my ability to engage in certain activities in light of this disease and its aftermath.

As you know, Cushing’s is a rarely diagnosed endocrine disorder characterized by hypercortisolism.

Surviving Cushing’s Disease: A Young Man’s Journey

Sat, 09 May 2026 04:00:00 EST

(Sat, 09 May 2026 )

This narrative nonfiction novel chronicles my son’s twenty-year journey to get his Cushing’s disease diagnosed—a journey that took far too long.

Throughout the book, I highlight opportunities for testing that could have been done according to endocrinologist guidelines.

The core message is clear: early diagnosis is crucial for people to live vibrant lives.

Read Surviving Cushing’s Disease: A Young Man’s Journey.

Osilodrostat-associated Adrenal Gland Shrinkage: a Case Series of Patients with ACTH-Dependent Cushing’s Syndrome

Sat, 09 May 2026 05:00:00 EST

(Sat, 09 May 2026 )

Medical therapy for Cushing’s syndrome (CS) is increasingly used. A potent adrenal steroidogenesis inhibitor, osilodrostat, has been rarely linked to prolonged adrenal insufficiency (AI).

https://cushings.invisionzone.com/topic/57897-osilodrostat-associated-adrenal-gland-shrinkage-a-case-series-of-patients-with-acth-dependent-cushing%E2%80%99s-syndrome/

Dee (Dee), Pituitary Bio

Sat, 09 May 2026 05:00:00 EST

(Sat, 09 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Carlin, Recovered from Pituitary Tumor

Sat, 09 May 2026 06:00:00 EST

(Sat, 09 May 2026 )

Carlin is from the Napa Valley CA. USA.

I’m 66 yo and have recovered from Cushings but now take hydrocortisone, thyroxine, ddavp and citalopram. It’s was a real fight to find a dr who believed me. (my GP said I was a morbidly obese hypochondriac).

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sat, 09 May 2026 06:00:00 EST

(Sat, 09 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Comment added to Celebrities with Cushing’s

Sat, 09 May 2026 06:00:00 EST

(Sat, 09 May 2026 )

I read Kevin Sorbo developed Cushings as a result of his Steroid usage on “Hercules, the Legendary Journeys”. I recall them saying that’s why the series ended. He actually tore tissue and muscle. Can anyone confirm?

Related Factors of Delirium After Transsphenoidal Endoscopic Pituitary Adenoma Resection

Sat, 09 May 2026 06:00:00 EST

(Sat, 09 May 2026 )

The primary aim of this study is to explore the factors associated with delirium incidence in postoperative patients who have undergone endoscopic transsphenoidal approach surgery for pituitary adenoma.

Janet (janetelizabeth), Adrenal Bio

Sat, 09 May 2026 06:00:00 EST

(Sat, 09 May 2026 )

I have recently been diagnosed with cushings syndrome and awaiting removal of gland and tumour.

https://cushingsbios.com/2025/11/07/janet-janetelizabeth-adrenal-bio/

Cushing's Basics: The Endocrine System

Sat, 09 May 2026 07:00:00 EST

(Sat, 09 May 2026 )

The endocrine system is a complex network of glands and organs. It uses hormones to control and coordinate your body's metabolism, energy level, reproduction, growth and development, and response to injury, stress, and mood. The following are integral parts of the endocrine system..

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sat, 09 May 2026 07:00:00 EST

(Sat, 09 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Cushing’s Syndrome: A Tale of Frequent Misdiagnosis

Sat, 09 May 2026 08:00:00 EST

(Sat, 09 May 2026 )

Cushing’s syndrome is considered rare, but that may be because it is under-reported. As a result, we don’t have good estimates for how many people have it, which is why the estimates for the actual number of cases vary so much–from 5 to 28 million people. The most common age group that Cushing’s affects are those 20 to 50 years old. It is thought that obesity, type 2 diabetes, and high blood pressure may increase your risk of developing this syndrome.

New Testimonial From Facebook

Sat, 09 May 2026 08:00:00 EST

(Sat, 09 May 2026 )

…for Mary Kelly O'Connor and her diligence in creating a support group website that many of us feel was literally a lifesaver.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Sat, 09 May 2026 08:00:00 EST

(Sat, 09 May 2026 )

Acromegaly: Chronic disease root of young man's abnormally gray hair and facial changes

Sat, 09 May 2026 09:00:00 EST

(Sat, 09 May 2026 )

A chronic, progressive disease was discovered to be the reason why a man in his 20s experienced a sudden increase of gray hair and facial changes, local doctors said…

Doctors suspected he suffered from acromegaly, a chronic disease characterized by enlargement of head bones, soft parts of the feet and hands and sometimes other parts of the body due to excessive secretion of growth hormones by the pituitary gland.

Vision Loss May Herald Brain Tumor

Sat, 09 May 2026 09:00:00 EST

(Sat, 09 May 2026 )

Tumors arising in the pituitary gland show symptoms either due to excessive hormone secretion or due to excessive growth and compression and spread to the surrounding tissues. Adenomas that do not secrete hormones usually grow slowly and can remain asymptomatic for years. Those who secrete hormones show early symptoms due to the effects of hormones in the body…

Cushing's - In ACTH excess; fat in abnormal areas of the body, muscle weakness, high blood pressure and blood sugar, skin oily and acne development, stretch marks, psychological problems.

Helpful Doctors: Dr. Sandeep Kunwar

Sat, 09 May 2026 09:00:00 EST

(Sat, 09 May 2026 )

Dr. Kunwar specializes in gamma knife radiosurgery for metastatic and primary brain tumors, and uses the endonasal approach for pituitary tumors. His research works to improve surgical therapy for brain tumors, particularly glioblastomas. He has pioneered a minimally invasive surgical technique for skull-based tumors and has successfully applied that skill to transcranial and spine patients as well.

Radiation-induced Undifferentiated Malignant Pituitary Tumor After 5 Years of Treatment for Cushing Disease

Sat, 09 May 2026 09:00:00 EST

(Sat, 09 May 2026 )

The incidence of a second pituitary tumor in patients irradiated for adrenocorticotropic hormone secreting pituitary adenoma is rare. We report a case of a 40-year-old female with Cushing disease who underwent surgical management followed by radiotherapy.

A Case Series of Bilateral Inferior Petrosal Sinus Sampling Using Desmopressin for Evaluation of ACTH-Dependent Cushing’s Syndrome in Pediatric Patients

Sat, 09 May 2026 10:00:00 EST

(Sat, 09 May 2026 )

Pediatric Cushing Syndrome (CS) is rare and difficult to diagnose, especially when distinguishing ACTH-dependent subtypes. Bilateral inferior petrosal sinus sampling (BIPSS) is an essential but technically challenging procedure for this purpose.

https://cushings.invisionzone.com/topic/57839-a-case-series-of-bilateral-inferior-petrosal-sinus-sampling-using-desmopressin-for-evaluation-of-acth-dependent-cushing%E2%80%99s-syndrome-in-pediatric-patients/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sat, 09 May 2026 10:00:00 EST

(Sat, 09 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Interview Archive: JenS discussed Bilateral Adrenalectomy (BLA)

Sat, 09 May 2026 11:00:00 EST

(Sat, 09 May 2026 )

Jen had Pituitary surgery by Dr. Shahinian 4/28/04, removed ACTH secreting corticotroph hyperplasia and prolactinoma.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sat, 09 May 2026 11:00:00 EST

(Sat, 09 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Cushing’s Syndrome in a Young Woman Due to Prolonged Betamethasone Nasal Drop Use

Sat, 09 May 2026 11:00:00 EST

(Sat, 09 May 2026 )

This report is about a 21-year-old Iranian woman using betamethasone nasal drops for nasal obstruction. The patient presented with weight gain, Amenorrhea, mood disturbances, red purplish striae, and mild hirsutism. Hormonal assessments revealed suppression of the hypothalamic–pituitary–adrenal axis.

https://cushings.invisionzone.com/topic/57861-cushing%E2%80%99s-syndrome-in-a-young-woman-due-to-prolonged-betamethasone-nasal-drop-use/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 10 May 2026 03:00:00 EST

(Sun, 10 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dee (Dee), Pituitary Bio

Sun, 10 May 2026 05:00:00 EST

(Sun, 10 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Complications and Mortality of Cushing’s Disease: Report on Data Collected Over a 20-Year Period at a Referral Centre

Sun, 10 May 2026 06:00:00 EST

(Sun, 10 May 2026 )

Patients with active Cushing's Disease presented a poor survival outcome. Remission restored the patients’ life expectancy regardless of the timing or the types of treatments used to achieve it. Persistent Cushing's Disease-related comorbidities remained major risk factors.

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 10 May 2026 06:00:00 EST

(Sun, 10 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 10 May 2026 07:00:00 EST

(Sun, 10 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Book - We Are Not Alone: Learning to Live with Chronic Illness

Sun, 10 May 2026 07:00:00 EST

(Sun, 10 May 2026 )

A twilight zone moment - I just started rereading this book again last night and this post from November 10, 2008 appeared on Facebook:

Hiding In Plain Sight: Florid Cushing’s Disease Presenting As A Severe Extremity Cellulitis

Sun, 10 May 2026 08:00:00 EST

(Sun, 10 May 2026 )

Cushing’s syndrome is a rare disease, and the constellation of clinical features can be overlooked if clinicians are not aware of the manifestations of hypercortisolism. We present the case of a patient with Cushing’s syndrome that went unrecognized with life-threatening sequelae.

18 Years Cancer-Free!

Sun, 10 May 2026 08:00:00 EST

(Sun, 10 May 2026 )

Today is the Eighteenth Anniversary of my kidney cancer surgery. These eighteen years have been bonus years for me. For my cancer stage, the 5-year survival rate was 81% and I’ve made it more than three times that long – so far.

(Korlym) Corcept settles patent dispute with Hikma over Cushing’s syndrome drug

Sun, 10 May 2026 09:00:00 EST

(Sun, 10 May 2026 )

Per the terms of the settlement, Corcept (CORT) has allowed Hikma (OTCPK:HKMPF) the rights to market a generic version of Korlym from Oct. 01, 2034, or earlier subject to certain conditions.

A Rare Case When Acromegaly Meets Cushing Syndrome

Sun, 10 May 2026 09:00:00 EST

(Sun, 10 May 2026 )

Acromegaly is very uncommon, as is non-iatrogenic Cushing syndrome; we discuss a patient who was found to have both a pituitary adenoma causing acromegaly and a cortisol-producing adrenal adenoma causing Cushing syndrome within 1 year.

Clinical Efficacy and Safety of Fluconazole Treatment in Patients with Cushing’s Syndrome

Sun, 10 May 2026 09:00:00 EST

(Sun, 10 May 2026 )

Ketoconazole is effective for treating Cushing’s syndrome (CS) but its use is limited by the risk of hepatotoxicity. Fluconazole, with similar antifungal properties, is being investigated as a potentially safer alternative for managing CS. This study aims to evaluate the efficacy and safety of fluconazole in patients with CS.

https://cushings.invisionzone.com/topic/57910-clinical-efficacy-and-safety-of-fluconazole-treatment-in-patients-with-cushing%E2%80%99s-syndrome/

A Case of Adrenocorticotropin-dependent Cushing Syndrome with Osilodrostat Exposure in Early Pregnancy

Sun, 10 May 2026 09:00:00 EST

(Sun, 10 May 2026 )

Active Cushing syndrome decreases fertility, which explains its rarity in pregnancy. Fewer than 250 cases have been documented. Whether it is ACTH-dependent or ACTH-independent, this disease poses significant risks to both mother and fetus. Its maternal complications include hypertension, preeclampsia, and diabetes, whereas the fetal risks include miscarriage, intrauterine growth restriction, and prematurity.

https://cushings.invisionzone.com/topic/57927-a-case-of-adrenocorticotropin-dependent-cushing-syndrome-with-osilodrostat-exposure-in-early-pregnancy/

What Do You Think? Medical Gaslighting

Sun, 10 May 2026 10:00:00 EST

(Sun, 10 May 2026 )

%MCEPASTEBIN%

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 10 May 2026 10:00:00 EST

(Sun, 10 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Cushing Syndrome Test Choice Should Fit Patient Factors & Disease Stage

Sun, 10 May 2026 10:00:00 EST

(Sun, 10 May 2026 )

Caused by excessive exposure to the hormone cortisol, endogenous Cushing syndrome (CS) is difficult to diagnose. Currently available biochemical tests that assess cortisol production have limited diagnostic specificity and sensitivity, and their performance can vary depending on the patient, according to a review article in Current Opinion in Endocrinology, Diabetes and Obesity.

https://cushings.invisionzone.com/topic/57898-cushing-syndrome-test-choice-should-fit-patient-factors-disease-stage/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 10 May 2026 11:00:00 EST

(Sun, 10 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Cushing’s Myths and Facts: “All types of Cushing’s are the same”

Sun, 10 May 2026 12:00:00 EST

(Sun, 10 May 2026 )

There are many genetic varieties with quite a few discovered in the past couple of years. Plus, there are several types such as adrenal, ectopic, and pituitary. And so on...

Adrenal Crisis: Still Deadly in the 21st Century.

Sun, 10 May 2026 12:00:00 EST

(Sun, 10 May 2026 )

Adrenal crisis is a life-threatening medical emergency, associated with a high mortality unless it is appropriately recognized and early treatment is rendered. Despite it being a treatable condition for almost 70 years, failure of adequate preventive measures or delayed treatment has often led to unnecessary deaths.

Watch video at https://cushings-help.com/2025/05/10/adrenal-crisis-still-deadly-in-the-21st-century/

An Ectopic Cushing’s Syndrome with Severe Psychiatric Presentation

Sun, 10 May 2026 15:00:00 EST

(Sun, 10 May 2026 )

We report a case of severe EAS in a young Tunisian man resulting from a well differentiated Neuroendocrine Tumor (NET) of the lung. Besides catabolic signs and profound hypokalemia orienting towards Cushing’s Syndrome (CS), psychiatric symptoms were particularly severe, dominant and atypical including persecutory delusions, depression and anxiety.

Diagnostic Performance of Desmopressin Stimulation Test in Pediatric Cushing’s Disease

Sun, 10 May 2026 18:00:00 EST

(Sun, 10 May 2026 )

To evaluate the diagnostic performance of the desmopressin (DDAVP) stimulation test in pediatric patients with Cushing’s disease (CD), and to compare its accuracy and safety profile to the ovine corticotropin-releasing hormone (oCRH) stimulation test.

https://cushings.invisionzone.com/topic/57940-diagnostic-performance-of-desmopressin-stimulation-test-in-pediatric-cushing%E2%80%99s-disease/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Mon, 11 May 2026 03:00:00 EST

(Mon, 11 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Complete Surgical Resection of Cortisol Secreting Neuroendocrine Thymic Tumour

Mon, 11 May 2026 03:00:00 EST

(Mon, 11 May 2026 )

43-year-old male presented with Cushing’s syndrome and was diagnosed with a cortical secreting atypical carcinoid of the thymus. He underwent a robotic thymectomy.

https://cushings.invisionzone.com/topic/57911-complete-surgical-resection-of-cortisol-secreting-neuroendocrine-thymic-tumour/

Whole Blood Transcriptomic Signature of Cushing's Syndrome

Mon, 11 May 2026 05:00:00 EST

(Mon, 11 May 2026 )

Whole blood transcriptome reflects the circulating levels of glucocorticoids. FKBP5 expression could be a nonhormonal marker of Cushing's syndrome.

Risk Comparison and Assessment Model of Deep Vein Thrombosis in Patients with Pituitary Adenomas After Surgery

Mon, 11 May 2026 05:00:00 EST

(Mon, 11 May 2026 )

Limited studies have identified a particularly elevated Venous thromboembolism (VTE) risk in patients with Cushing's disease, a hormone-secreting subtype of pituitary adenoma.

https://cushings.invisionzone.com/topic/57899-risk-comparison-and-assessment-model-of-deep-vein-thrombosis-in-patients-with-pituitary-adenomas-after-surgery/

Dee (Dee), Pituitary Bio

Mon, 11 May 2026 05:00:00 EST

(Mon, 11 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Mon, 11 May 2026 06:00:00 EST

(Mon, 11 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Mon, 11 May 2026 07:00:00 EST

(Mon, 11 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

BMD may Underestimate Bone Deterioration for Women with Endogenous Cushing’s Syndrome

Mon, 11 May 2026 07:00:00 EST

(Mon, 11 May 2026 )

Of the 40 women with Cushing’s syndrome, 32 were ACTH-dependent and the other eight were ACTH independent. Of the independent group, seven had adrenal adenoma and one had adrenocortical carcinoma.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Mon, 11 May 2026 08:00:00 EST

(Mon, 11 May 2026 )

Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome

Mon, 11 May 2026 09:00:00 EST

(Mon, 11 May 2026 )

Cushing syndrome (CS) is a rare disease caused by excess cortisol levels with high cardiovascular morbidity and mortality. Hypertension in CS promotes hypercortisolism-associated cardiovascular events.

Basics: What Is Moon Face?

Mon, 11 May 2026 09:00:00 EST

(Mon, 11 May 2026 )

Among the most common causes of moon face is Cushing's syndrome—a condition that occurs when your body makes too much cortisol, which is commonly referred to as the 'stress hormone.' One of the most common symptoms of Cushing's syndrome is moon face, but you might also experience darkening of the skin, weight gain, and muscle weakness.

Treatment-Resistant Cushing Disease and Acromegaly in a Young Woman: A Case Of Functional Pituitary Macroadenoma

Mon, 11 May 2026 09:00:00 EST

(Mon, 11 May 2026 )

Cushing disease and acromegaly are common endocrine disorders caused by excessive cortisol and growth hormone production, respectively. Both conditions can co-occur due to functioning pituitary adenomas, which are typically benign pituitary gland tumors. This report discusses a 30-year-old woman with hyperpituitarism leading to treatment-resistant Cushing disease and acromegaly caused by a functional pituitary macroadenoma.

https://cushings.invisionzone.com/topic/57793-treatment-resistant-cushing-disease-and-acromegaly-in-a-young-woman-a-case-of-functional-pituitary-macroadenoma/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Mon, 11 May 2026 10:00:00 EST

(Mon, 11 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Mary O’Connor (MaryO) second interview archive with Robin Smith (staticnrg)

Mon, 11 May 2026 11:00:00 EST

(Mon, 11 May 2026 )

Robin had Cushing's for over 20 years, at least. Of course, no one figured it out or even put two and two together until her new PCP whom she found in 2004 said 'endocrine'. She didn't figure it out, either, but at least Robin had a piece of the puzzle and she found cushings-help.com. Robin immediately went into denial and left for several months until she got so sick she knew she had to have help. She had originally sought this PCP because she had been going to all sorts of doctors.

Ectopic Cushing Syndrome in Metastatic Castration‑Resistant Prostate Cancer

Mon, 11 May 2026 11:00:00 EST

(Mon, 11 May 2026 )

Cushing's syndrome (CS), as a result of ectopic adrenocorticotropic hormone (ACTH) production, constitutes a common paraneoplastic manifestation of various malignancies, with the most common being small cell lung carcinoma. In the literature, fewer than fifty cases associating ectopic CS with prostate cancer have been documented. In the present study, the case of a 76‑year old man suffering from castration‑resistant prostate adenocarcinoma that had been treated with enzalutamide and luteinizing hormone‑releasing hormone (LHRH) analogue for the last four years is presented.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Mon, 11 May 2026 11:00:00 EST

(Mon, 11 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Basics: Testing: IGF-1 (Insulin-like growth factor 1)

Mon, 11 May 2026 12:00:00 EST

(Mon, 11 May 2026 )

IGF-1 is an important growth hormone, mediating the protein anabolic and linear growth promoting effect of pituitary GH. It has a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimised by the synergistic action with GH.

Osilodrostat for Cyclic Cushing’s Disease

Mon, 11 May 2026 12:00:00 EST

(Mon, 11 May 2026 )

Cyclic Cushing’s syndrome is a rare subtype of Cushing’s syndrome with episodes of hypercortisolism, followed by spontaneous remission.

https://cushings.invisionzone.com/topic/57900-osilodrostat-for-cyclic-cushing%E2%80%99s-disease/

Add or update Your Bio

Tue, 12 May 2026 01:00:00 EST

(Tue, 12 May 2026 )

Please add your bio. Your information will help others.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Tue, 12 May 2026 03:00:00 EST

(Tue, 12 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Endogenous Cushing's Syndrome Market Insights Highlight Expanding Outlook Till 2032

Tue, 12 May 2026 03:00:00 EST

(Tue, 12 May 2026 )

Endogenous Cushing's Syndrome is a rare hormonal disorder caused by the body's overproduction of cortisol, a hormone produced by the adrenal glands. This overproduction can result from tumors or abnormalities in the pituitary gland (Cushing's disease), adrenal glands, or other parts of the body that cause excessive cortisol secretion. It contrasts with exogenous Cushing's syndrome, which results from external sources like long-term use of corticosteroid medications.

https://cushings.invisionzone.com/topic/57912-endogenous-cushings-syndrome-market-insights-highlight-expanding-outlook-till-2032/

Alyssa, Pituitary Video

Tue, 12 May 2026 04:00:00 EST

(Tue, 12 May 2026 )

Alyssa is a busy wife and mother who finally found the time and space in her life to train as a triathlete. Everything went well until her body started to rebel. She and her doctors were mystified when her exercise was derailed by fatigue, unusual aches, and worst of all, a significant weight gain despite careful eating and loads of exercise.

https://cushingsbios.com/2025/06/12/alyssa-pituitary-video/

Dee (Dee), Pituitary Bio

Tue, 12 May 2026 05:00:00 EST

(Tue, 12 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Tue, 12 May 2026 06:00:00 EST

(Tue, 12 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Tue, 12 May 2026 07:00:00 EST

(Tue, 12 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Intensity-Modulated Radiotherapy for Cushing’s Disease: Single-Center Experience in 70 Patients

Tue, 12 May 2026 07:00:00 EST

(Tue, 12 May 2026 )

Intensity-Modulated Radiotherapy for Cushing’s Disease was a highly effective second-line therapy with low side effect profile for CD patients. Endocrine remission, tumor control and recurrence rates were comparable to previous reports on FRT and SRS.

Response to Osilodrostat Therapy in Adrenal Cushing’s Syndrome

Tue, 12 May 2026 08:00:00 EST

(Tue, 12 May 2026 )

Our study demonstrated that osilodrostat therapy in patients with CPA may require a different approach than that in CD, with higher doses, faster dose escalation, and a possible initial inverse response or lack of response.

Archived Interview: Cushing’s Diagnosis and Symptoms, part 2

Tue, 12 May 2026 09:00:00 EST

(Tue, 12 May 2026 )

Listen as Robin Smith (staticnrg) and Mary O’Connor (MaryO) co-host Cushing’s message board members calling in to talk about their fight for diagnosis and treatment. The show will be opened with a brief explanation of what Cushing’s is and what the symptoms are.

Listen at https://cushieblogger.com/2022/04/12/archived-interview-cushings-diagnosis-and-symptoms-part-2-2/

Prospective Assessment of Mood and Quality of Life in Cushing syndrome before and after Biochemical Control

Tue, 12 May 2026 09:00:00 EST

(Tue, 12 May 2026 )

Although effective treatment improves mood and Quality of Life in Cushing's Syndrome, clinically meaningful recovery is variable and incomplete for some patients.

https://cushings.invisionzone.com/topic/57913-prospective-assessment-of-mood-and-quality-of-life-in-cushing-syndrome-before-and-after-biochemical-control/

Ectopic Adrenocorticotropic Hormone Syndrome Due To Olfactory Neuroblastoma: A Case Report And Literature Review

Tue, 12 May 2026 10:00:00 EST

(Tue, 12 May 2026 )

Production of adrenocorticotropic hormone (ACTH) from nonpituitary tumors – known as ectopic ACTH syndrome (EAS) – is the cause of ACTH-dependent hypercortisolism in up to 18% of all cases of Cushing's syndrome.

https://cushings.invisionzone.com/topic/57851-ectopic-adrenocorticotropic-hormone-syndrome-due-to-olfactory-neuroblastoma-a-case-report-and-literature-review/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Tue, 12 May 2026 10:00:00 EST

(Tue, 12 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Tue, 12 May 2026 11:00:00 EST

(Tue, 12 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Once-Daily Treatment for Cushing Syndrome May Safely Restore Cortisol Rhythms

Tue, 12 May 2026 19:00:00 EST

(Tue, 12 May 2026 )

Once-daily evening osilodrostat improved cortisol rhythms, sleep, and quality of life in Cushing syndrome without compromising disease control or safety.

https://cushings.invisionzone.com/topic/57841-once-daily-treatment-for-cushing-syndrome-may-safely-restore-cortisol-rhythms/

Spontaneous Cushing’s Disease Remission Induced by Pituitary Apoplexy

Tue, 12 May 2026 22:00:00 EST

(Tue, 12 May 2026 )

Spontaneous remission of Cushing’s disease (CD) is uncommon and often attributed to pituitary tumor apoplexy. We present a case involving a 14-year-old female who exhibited clinical features of Cushing’s syndrome.

Cushie MemberMap

Wed, 13 May 2026 01:00:00 EST

(Wed, 13 May 2026 )

Add your own info (or your doctor's) to the Cushie MemberMap at https://cushieblogger.com/2018/11/17/rebuilding-the-membermap/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Wed, 13 May 2026 03:00:00 EST

(Wed, 13 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Rapid Endocrine Remission After ZAP-X Gyroscopic Radiosurgery for Cushing’s Disease

Wed, 13 May 2026 05:00:00 EST

(Wed, 13 May 2026 )

A 48-year-old female with an unremarkable medical history except for hyperlipidemia underwent investigation in 2018 due to symptoms and findings consistent with Cushing's syndrome, leading to the detection of hypercortisolism.

https://cushings.invisionzone.com/topic/57914-rapid-endocrine-remission-after-zap-x-gyroscopic-radiosurgery-for-cushing%E2%80%99s-disease/

Dee (Dee), Pituitary Bio

Wed, 13 May 2026 05:00:00 EST

(Wed, 13 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Wed, 13 May 2026 06:00:00 EST

(Wed, 13 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Wed, 13 May 2026 07:00:00 EST

(Wed, 13 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Ectopic Adrenocorticotropic Hormone (ACTH)-Dependent Cushing Syndrome Secondary to Olfactory Neuroblastoma

Wed, 13 May 2026 07:00:00 EST

(Wed, 13 May 2026 )

This report presents a case of ACTH-dependent Cushing syndrome due to Olfactory neuroblastoma (ONB), emphasizing the diagnostic complexity, multidisciplinary management, and favorable clinical outcomes.

https://cushings.invisionzone.com/topic/57879-ectopic-adrenocorticotropic-hormone-acth-dependent-cushing-syndrome-secondary-to-olfactory-neuroblastoma/

Helpful Doctors: Dr. Fernandez-Miranda

Wed, 13 May 2026 09:00:00 EST

(Wed, 13 May 2026 )

I was then fortunate to continue my clinical training at University of Virginia with several giants of neurosurgery, and I was greatly influenced by the meticulous approach of Dr. Ed Oldfield’s pituitary surgeries, particularly for Cushing’s disease. It was such a joy to watch his precise extracapsular tumor resections. At the same time, I had become totally enchanted by the endoscopic endonasal operations that Dr. Amin Kassam was performing at University of Pittsburgh, and after many requests he finally accepted me for specialized training with him and his team. That was a life changing event for me, as my career was about to be centered in the development and refinement of endoscopic endonasal skull base and pituitary surgery.

Adrenal Gland Volume Measurement Could Assist Surgery Option in Patients With Primary Pigmented Nodular Adrenocortical Disease

Wed, 13 May 2026 09:00:00 EST

(Wed, 13 May 2026 )

Primary pigmented nodular adrenocortical disease is a rare form of adrenocorticotropic hormone–independent Cushing syndrome originating from bilateral adrenal lesions.

https://cushings.invisionzone.com/topic/57852-adrenal-gland-volume-measurement-could-assist-surgery-option-in-patients-with-primary-pigmented-nodular-adrenocortical-disease/

New Area For Cushing's Basics

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

We'll periodically post basic Cushing's info here - along with updated info if available.

Please feel free to ask questions to learn more about Cushing's, testing, treatments and such.

Find it at https://cushings.invisionzone.com/forum/321-cushings-basics/

What Do You Think? Women, Patients of Color Warning About 'Medical Gaslighting'

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

One area where the problem of medical gaslighting is a huge issue is in the area of autoimmune diseases. So, we know that almost 80% of autoimmune disease sufferers are women, and there hasn't been nearly enough research into how to diagnose some of these diseases and how to recognize their symptoms. And as a result, a lot of women with autoimmune diseases say that when they have first gone to doctors, their symptoms have been dismissed, or doctors have said, 'It's just anxiety -- maybe you should go on an antidepressant,' something like that.

Express your thoughts at https://cushings.invisionzone.com/topic/56824-what-do-you-think-women-patients-of-color-warning-about-medical-gaslighting/

Bridget H, Ectopic Cushing's

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

Findling ordered a dotatate PET scan to find where Houser's tumor was, finding it in her left lung. Ultimately, after much deliberation, Houser elected to undergo surgery to remove part of her left lung. A pathologist found the tumor was a rare, slow-growing neuroendocrine lung cancer known as bronchial carcinoid, which can cause Cushing's.

Metformin Inhibits Cell Proliferation and ACTH Secretion In AtT20 Cells Via Regulating the Mapk Pathway

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

In conclusion, metformin inhibits tumor progression and ACTH secretion, potentially through suppression of the MAPK pathway in AtT20 cell lines. These findings suggest metformin as a potential drug for the treatment of Cushing's disease.

Olfactory Neuroblastoma Causing Cushing’s Syndrome Due to the Ectopic Adrenocorticotropic Hormone (ACTH) Secretion

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

Cushing’s syndrome is a constellation of features occurring due to high blood cortisol levels. We report a case of a 47-year-old male with a history of recurrent olfactory neuroblastoma (ONB). He presented with bilateral lower limb weakness and anosmia and was found to have Cushing’s syndrome due to high adrenocorticotropic hormone (ACTH) levels from an ectopic source, ONB in this case. Serum cortisol and ACTH levels declined after tumor removal.

A Case 0f Hailey–Hailey Disease Accompanied by Cushing’s Syndrome and Adrenal Insufficiency Due to Long-Term Usage of Topical Steroids With Review of Literature

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

Here, we report the case of a 50-year-old woman with HHD who had been using topical clobetasol or betamethasone for over 10 years, reaching doses up to 50 g/day.

She developed Cushingoid features, metabolic abnormalities, and suppression of the hypothalamic–pituitary–adrenal (HPA) axis. After tapering off topical corticosteroids, she developed adrenal insufficiency and associated withdrawal symptoms. Following the initiation of hydrocortisone replacement therapy, psychiatric symptoms, impaired glucose tolerance, and osteoporotic fractures emerged, suggesting exacerbation of iatrogenic Cushing’s syndrome.

https://cushings.invisionzone.com/topic/57862-a-case-0f-hailey%E2%80%93hailey-disease-accompanied-by-cushing%E2%80%99s-syndrome-and-adrenal-insufficiency-due-to-long-term-usage-of-topical-steroids-with-review-of-literature/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Wed, 13 May 2026 10:00:00 EST

(Wed, 13 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Wed, 13 May 2026 11:00:00 EST

(Wed, 13 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Crooke Cell Adenoma Confers Poorer Endocrinological Outcomes Compared with Corticotroph Adenoma

Wed, 13 May 2026 18:00:00 EST

(Wed, 13 May 2026 )

Crooke cell adenomas (CCA) are a rare, aggressive subset of adrenocorticotrophin secreting pituitary corticotroph adenomas (sCTA) found in 5–10% of patients with Cushing’s disease. Multiple studies support worse outcomes in CCA but are limited by small sample size and single-institution databases. We compared outcomes in CCA and sCTA using a multicenter, international retrospective database of high-volume skull base centers.

Need Help Paying for your Meds?

Wed, 13 May 2026 19:00:00 EST

(Wed, 13 May 2026 )

Since 1987, NORD has provided assistance programs to help patients obtain life-saving or life-sustaining medication they could not otherwise afford. These programs provide medication, financial assistance with insurance premiums and co-pays, diagnostic testing assistance, and travel assistance for clinical trials or consultation with disease specialists.

Osteoporosis as the First Sign of Cushing’s Disease in a Thin 16-Year-Old Boy

Thu, 14 May 2026 03:00:00 EST

(Thu, 14 May 2026 )

Cushing’s disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short stature, the boy underwent diagnostics, which excluded growth hormone (GH) deficiency, hypothyroidism and celiac disease. Finally, based on cortisol profile results, dexamethasone suppression tests and bilateral sampling during catheterization of the inferior petrosal sinuses, CD was diagnosed.

Ectopic CRH/ACTH-Co-Secreting Neuroendocrine Tumors Leading to Cushing's Disease

Thu, 14 May 2026 03:00:00 EST

(Thu, 14 May 2026 )

We report the case of a 53-year-old female patient who presented with severe Cushing’s syndrome and was diagnosed with ectopic ACTH syndrome. Despite initial indications pointing towards pituitary-dependent hypercortisolism, further investigations revealed the presence of a highly differentiated atypically located tumor in the upper lobe of the left lung, adjacent to the mediastinum. Immunohistochemistry of the tumor tissue demonstrated not only ACTH but also CRH and CRH-R1 expression.

https://cushings.invisionzone.com/topic/57795-ectopic-crhacth-co-secreting-neuroendocrine-tumors-leading-to-cushings-disease/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Thu, 14 May 2026 03:00:00 EST

(Thu, 14 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Rare Challenges in Diagnosing Cushing’s Syndrome and Primary Aldosteronism: A Case Report of a Female With a Negative Workup

Thu, 14 May 2026 04:00:00 EST

(Thu, 14 May 2026 )

Cushing’s syndrome with concurrent primary aldosteronism (PA) is a rare presentation, and establishing an early diagnosis is imperative to preventing morbidity and long-term sequelae. The diagnosis is established by sequential lab work, showing an elevated cortisol and aldosterone level.

Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission

Thu, 14 May 2026 04:00:00 EST

(Thu, 14 May 2026 )

Bone material properties remain altered in patients with endogenous CS, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.

https://cushings.invisionzone.com/topic/57772-bone-material-strength-index-is-low-in-patients-with-cushings-syndrome-even-after-long-term-remission/

Delirium Induced by Rapid Titration of Osilodrostat in a Patient With Cushing’s Disease

Thu, 14 May 2026 05:00:00 EST

(Thu, 14 May 2026 )

Cushing’s disease frequently presents with psychiatric symptoms such as depression, anxiety, and cognitive impairment. Osilodrostat, an 11β-hydroxylase inhibitor, is used for persistent or recurrent cases, but rapid titration may precipitate adrenal insufficiency and psychiatric complications.

https://cushings.invisionzone.com/topic/57915-delirium-induced-by-rapid-titration-of-osilodrostat-in-a-patient-with-cushing%E2%80%99s-disease/

Dee (Dee), Pituitary Bio

Thu, 14 May 2026 05:00:00 EST

(Thu, 14 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Thu, 14 May 2026 06:00:00 EST

(Thu, 14 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Thu, 14 May 2026 07:00:00 EST

(Thu, 14 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Treatment-Resistant Depression with Acute Psychosis in an Adolescent Girl with Cushing's Syndrome

Thu, 14 May 2026 08:00:00 EST

(Thu, 14 May 2026 )

Cushing's syndrome (CS) is a rare disease with multiple somatic signs and a high prevalence of co-occurring depression. However, the characteristics of depression secondary to CS and the differences from major depression have not been described in detail. In this case, we report a 17-year-old girl with treatment-resistant depression with a series of atypical features and acute psychotic episodes, which is a rare condition secondary to CS.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Thu, 14 May 2026 10:00:00 EST

(Thu, 14 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Thu, 14 May 2026 11:00:00 EST

(Thu, 14 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

ISTURISA® (osilodrostat) Now Available in Canada for the Treatment of Cushing's Disease

Fri, 15 May 2026 02:00:00 EST

(Fri, 15 May 2026 )

ISTURISA® (osilodrostat) is indicated for the treatment of adult patients with Cushing's disease who have persistent or recurrent hypercortisolism after primary pituitary surgery and/or irradiation, or for whom pituitary surgery is not an option.

https://cushings.invisionzone.com/topic/57941-isturisa%C2%AE-osilodrostat-now-available-in-canada-for-the-treatment-of-cushings-disease/

Anita S, Adrenal Bio

Fri, 15 May 2026 03:00:00 EST

(Fri, 15 May 2026 )

Anita is from Rye, Colorado

She was diagnosed with Cushing's in the summer of 2020 and now has an adrenal adenoma on heright.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Fri, 15 May 2026 03:00:00 EST

(Fri, 15 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Comment added to Day 16, Cushing’s Awareness Challenge

Fri, 15 May 2026 04:00:00 EST

(Fri, 15 May 2026 )

Boy, I really needed to reread this again today.

Many thanks again...to me!...for sharing.

Except for my new 'hobby' of learning the balalaika, everything is seeming painful, blah, boring and, at times, plain annoying.

Efficacy and Safety of Pasireotide in Patients With Cushing’s Disease

Fri, 15 May 2026 04:00:00 EST

(Fri, 15 May 2026 )

Pasireotide is the first pituitary-directed approved therapy for Cushing’s disease (CD), effective in reducing 24 h urine free cortisol (UFC) > 50% in more than half of patients, with beneficial effects and with a relatively high incidence of hyperglycemia. The aim of this study was to evaluate efficacy and safety of long-term treatment with pasireotide (PAS) in CD patients, also according to gender.

https://cushings.invisionzone.com/topic/57812-efficacy-and-safety-of-pasireotide-in-patients-with-cushing%E2%80%99s-disease/

Helpful Doctors: Ohio

Fri, 15 May 2026 05:00:00 EST

(Fri, 15 May 2026 )

Dr. Correa has special expertise in transgender medicine; neuroendocrinology; and caring for adults with adrenal disorders, such as Cushing's syndrome, Addison's disease, primary hyperaldosteronism, neuroendocrine tumors, and rare endocrine conditions.

Comment added to Day 15, Cushing’s Awareness Challenge

Fri, 15 May 2026 05:00:00 EST

(Fri, 15 May 2026 )

Cushing's awareness discussions come out in the oddest ways.

Last night, we were out at a Lebanese restaurant couple with a young couple from India and were talking about foods we liked. I said that I liked spicy foods in general.

That led to the fact that I haven't had a good sense of smell since my transsphenoidal surgery and that things taste better when I can smell them. That got us around to why I'd had the surgery and what the symptoms of Cushing's are....

Dee (Dee), Pituitary Bio

Fri, 15 May 2026 05:00:00 EST

(Fri, 15 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Fri, 15 May 2026 06:00:00 EST

(Fri, 15 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Fri, 15 May 2026 07:00:00 EST

(Fri, 15 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Basics: Meds - Korlym

Fri, 15 May 2026 08:00:00 EST

(Fri, 15 May 2026 )

Korlym (mifepristone), developed and marketed by Corcept Therapeutics, is an FDA-approved treatment for high blood sugar (hyperglycemia) in adults with Cushing’s syndrome who have type 2 diabetes or glucose intolerance, and for whom surgery is not an option, or failed to control their symptoms.

Cushing Syndrome - A Review

Fri, 15 May 2026 08:00:00 EST

(Fri, 15 May 2026 )

Cushing syndrome characteristically presents with skin changes such as facial plethora, easy bruising, and purple striae and with metabolic manifestations such as hyperglycemia, hypertension, and excess fat deposition in the face, back of the neck, and visceral organs.

Epicardial and Pericoronary Adipose Tissue and Coronary Plaque Burden in Patients with Cushing’s Syndrome

Fri, 15 May 2026 08:00:00 EST

(Fri, 15 May 2026 )

The purpose was to assess coronary inflammation by measuring the volume and density of the epicardial adipose tissue (EAT), perivascular fat attenuation index (FAI) and coronary plaque burden in patients with Cushing’s syndrome (CS) based on coronary computed tomography angiography (CCTA).

A Rare Case of PRKACA Duplication–Associated Childhood-Onset Primary Pigmented Nodular Adrenocortical Disease

Fri, 15 May 2026 10:00:00 EST

(Fri, 15 May 2026 )

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare but important cause of adrenocorticotropic hormone (ACTH)-independent Cushing syndrome (CS). It usually presents as cyclical CS in young adults. Childhood onset of PPNAD is exceedingly rare. About 90% of cases of PPNAD are associated with Carney complex (CNC).

https://cushings.invisionzone.com/topic/57796-a-rare-case-of-prkaca-duplication%E2%80%93associated-childhood-onset-primary-pigmented-nodular-adrenocortical-disease/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Fri, 15 May 2026 10:00:00 EST

(Fri, 15 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Fri, 15 May 2026 11:00:00 EST

(Fri, 15 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

The Role of Late-Night Salivary Cortisol in the Assessment of Endocrine Remission in Patients With Cushing's Disease After Pituitary Radiotherapy

Fri, 15 May 2026 11:00:00 EST

(Fri, 15 May 2026 )

Pituitary radiotherapy (RT) is used for persistent/recurrent Cushing's disease (CD) after pituitary surgery. The utility of late-night salivary cortisol (LNSC) in evaluating endocrine remission after RT is unclear.

https://cushings.invisionzone.com/topic/57829-the-role-of-late-night-salivary-cortisol-in-the-assessment-of-endocrine-remission-in-patients-with-cushings-disease-after-pituitary-radiotherapy/

Archived Interview: Jenn, Steroid Induced (Iatrogenic) Cushing’s patient

Fri, 15 May 2026 15:00:00 EST

(Fri, 15 May 2026 )

Jenn (StaceyJenn) was diagnosed with adrenal insufficiency, hypothyroidism, and a host of other ailments in 2001 (candidiasis, intestinal permeability, 22 latent food allergies). Once diagnosed, she was on specially formulated hydrocortisone for 7 years as she was allergic to the fillers in the meds...

Listen at https://cushieblogger.com/2019/04/15/archived-interview-jenn-steroid-induced-iatrogenic-cushings-patient/

Bilateral Inferior Petrosal Sinus Sampling: Validity, Diagnostic Accuracy in Lateralization of Pituitary Microadenoma, and Treatment In Eleven Patients with Cushing’s Syndrome – a Single-Center Retrospective Cohort Study

Fri, 15 May 2026 17:00:00 EST

(Fri, 15 May 2026 )

This study suggests that BIPSS may be a reliable and low-complication technique in evaluating patients with ACTH-dependent CS who had inconclusive imaging and biochemical test results. The diagnostic accuracy is improved by DDAVP stimulation. Pituitary adenoma lateralization can be predicted with the aid of BIPSS.

Teenager Overcomes Brain Tumour and Shares His Experience (Hypopituitarism)

Sat, 16 May 2026 03:00:00 EST

(Sat, 16 May 2026 )

The tumour affected teenager Niall’s pituitary gland, resulting in a condition known as hypopituitarism.

Epigenetic Mechanisms Modulated by Glucocorticoids With a Focus on Cushing Syndrome

Sat, 16 May 2026 03:00:00 EST

(Sat, 16 May 2026 )

In Cushing syndrome (CS), prolonged exposure to high cortisol levels results in a wide range of devastating effects causing multisystem morbidity.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sat, 16 May 2026 03:00:00 EST

(Sat, 16 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

First Oral Therapy for Rare Adrenal Gland Tumors Gets Green Light From FDA

Sat, 16 May 2026 05:00:00 EST

(Sat, 16 May 2026 )

The FDA has expanded the approval of belzutifanopens in a new tab or window (Welireg) to include certain types of pheochromocytoma or paraganglioma (PPGL) in adults and children.

The action establishes belzutifan as the only approved oral therapy for PPGL. The approval stipulates use in adults and children 12 years or older with locally advanced, unresectable, or metastatic PPGL.

https://cushings.invisionzone.com/topic/57827-first-oral-therapy-for-rare-adrenal-gland-tumors-gets-green-light-from-fda/

Dee (Dee), Pituitary Bio

Sat, 16 May 2026 05:00:00 EST

(Sat, 16 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Cushing's Basics: Testing: Inferior Petrosal Sinus Sampling

Sat, 16 May 2026 06:00:00 EST

(Sat, 16 May 2026 )

Video, personal stories and 'official information'.

The MRI still showed nothing, so they did a Petrosal Sinus Sampling Test. That scared me more than the prospect of surgery. (This test carries the risk of stroke and uncontrollable bleeding from the incision points.)

Catheters were fed from my groin area to my pituitary gland and dye was injected. I could watch the whole procedure on monitors. I could not move during this test or for several hours afterwards to prevent uncontrollable bleeding from a major artery.

The test did show where the tumor probably was located...

Novel Application of Amniotic Membrane Saves Adrenal Tissue in Patients Undergoing Adrenal Surgery

Sat, 16 May 2026 06:00:00 EST

(Sat, 16 May 2026 )

The goal is to leave some normal adrenal tissue so that the patient can avoid adrenal insufficiency which requires a daily dose of several adrenal hormones and steroids. Partial adrenal surgery is especially beneficial for patients with pheochromocytoma, as well as Conn's and Cushing's syndrome. Avoiding daily steroids is life-changing for these patients so this is a major breakthrough.'

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sat, 16 May 2026 06:00:00 EST

(Sat, 16 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Janet (janetelizabeth), Adrenal Bio

Sat, 16 May 2026 06:00:00 EST

(Sat, 16 May 2026 )

I have recently been diagnosed with cushings syndrome and awaiting removal of gland and tumour.

https://cushingsbios.com/2025/11/07/janet-janetelizabeth-adrenal-bio/

Comment added to Niamh (niamhiblog), Adrenal Bio

Sat, 16 May 2026 07:00:00 EST

(Sat, 16 May 2026 )

I have a tumour on my right adrenal gland and diagnosed with Cushings 3 years ago . Covid got in the way of surgery initially so now I wait and I wait. I try to keep going but I really just want to stay in bed as I’ve little energy, poor concentration and less interest…

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sat, 16 May 2026 07:00:00 EST

(Sat, 16 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Asymptomatic Pheochromocytoma Associated with MEN Syndrome and Subclinical Cushing's Syndrome

Sat, 16 May 2026 08:00:00 EST

(Sat, 16 May 2026 )

Pheochromocytoma and Cushing's syndrome are rare endocrine conditions caused by tumors in the adrenal gland. These conditions are classified under Multiple Endocrine Neoplasia (MEN) syndrome...

What Was the Most Memorable Thing that Happened to YOU Last Year?

Sat, 16 May 2026 08:00:00 EST

(Sat, 16 May 2026 )

Basics: Pseudo-Cushing’s syndrome

Sat, 16 May 2026 09:00:00 EST

(Sat, 16 May 2026 )

Pseudo-Cushing’s syndrome is when symptoms are similar to those of Cushing’s syndrome, but further tests show that the syndrome is not present.

Cushing’s Syndrome is Associated with Early Medical- and Surgical-related Complications Following Total Joint Arthroplasty

Sat, 16 May 2026 09:00:00 EST

(Sat, 16 May 2026 )

Cushing’s syndrome is associated with early medical- and surgical-related complications following total joint arthroplasty and a reduced incidence of manipulation under anesthesia following total knee arthroplasty.

Clinical Efficacy and Safety of Fluconazole Treatment in Patients with Cushing’s Syndrome

Sat, 16 May 2026 09:00:00 EST

(Sat, 16 May 2026 )

https://cushings.invisionzone.com/topic/57916-clinical-efficacy-and-safety-of-fluconazole-treatment-in-patients-with-cushing%E2%80%99s-syndrome/

Call 911! Adrenal Crisis, Addison's/Adrenal Insufficiency

Sat, 16 May 2026 10:00:00 EST

(Sat, 16 May 2026 )

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Violaceous Abdominal Striae Noted on Physical Examination: A Clue to the Diagnosis of Cushing’s Syndrome

Sat, 16 May 2026 10:00:00 EST

(Sat, 16 May 2026 )

Doctors should suspect Cushing’s syndrome when they see patients with purple stretch marks and metabolic conditions such as diabetes, even if those symptoms aren’t the reasons for a medical visit, physicians in Japan wrote in a case study describing how they reached that diagnosis for a woman in her early 30s.

Insights on Diagnosing and Managing Cushing’s Syndrome

Sat, 16 May 2026 10:00:00 EST

(Sat, 16 May 2026 )

A lot of Cushing’s patients are getting diagnosed and treated in primary care, which is completely appropriate. But I’ve also met endocrinologists who are uncomfortable diagnosing and managing Cushing’s because it is so rare,” she said.

Mortality in Cushing’s Syndrome: Declining Over Two Decades but Remaining Higher Than the General Population

Sat, 16 May 2026 10:00:00 EST

(Sat, 16 May 2026 )

Patients with endogenous Cushing’s syndrome (CS) have elevated mortality, particularly during active disease. A recent meta-analysis reported reduced mortality rates after 2000 in adrenal CS and Cushing disease (CD), though many studies lacked population-matched controls.

https://cushings.invisionzone.com/topic/57813-mortality-in-cushing%E2%80%99s-syndrome-declining-over-two-decades-but-remaining-higher-than-the-general-population/

Novel Cushing's Syndrome Drug Improves Hypertension, Hyperglycemia

Sat, 16 May 2026 10:00:00 EST

(Sat, 16 May 2026 )

Relacorilant works differently than other agents indicated for endogenous hypercortisolism (also known as Cushing's syndrome) like the nonselective glucocorticoid receptor antagonist mifepristone (Korlym), which can be difficult to use given its drug-drug interactions and side effects like endometrial hypertrophy and vaginal bleeding.

https://cushings.invisionzone.com/topic/57853-novel-cushings-syndrome-drug-improves-hypertension-hyperglycemia/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sat, 16 May 2026 10:00:00 EST

(Sat, 16 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sat, 16 May 2026 11:00:00 EST

(Sat, 16 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Archived Interview: Terry G, pituitary patient

Sat, 16 May 2026 18:00:00 EST

(Sat, 16 May 2026 )

Terry (Terry) is a long time pituitary Cushing’s survivor. Terry had a pituitary surgery (in LA) in October of 2003 which did not cure her Cushing’s Disease. Then, Dec 13th, 2003 she had her BLA in a Wisconsin hospital. She also had an infection in her sphenoid sinus. It originated at the site of her pituitary surgery from October 2003. She had to be on a lot of antibiotics and narcotic pain relievers. In Sept 2005 the surgeon remove the infection from one area, making another area clear…..

Listen at https://cushieblogger.com/2019/04/16/archived-interview-terry-g-pituitary-patient/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 17 May 2026 03:00:00 EST

(Sun, 17 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Approach to the Patient with Cushing’s Syndrome: Use of Anticoagulation Therapy

Sun, 17 May 2026 04:00:00 EST

(Sun, 17 May 2026 )

There is an increased awareness on the higher hypecoagulability risks in patients with Cushing’s syndrome (CS) but management remains controversial.

https://cushings.invisionzone.com/topic/57928-approach-to-the-patient-with-cushing%E2%80%99s-syndrome-use-of-anticoagulation-therapy/

Final Diagnosis: ACTH-dependent Cushing’s syndrome • ectopic ACTH syndrome

Sun, 17 May 2026 05:00:00 EST

(Sun, 17 May 2026 )

Adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (CS) secondary to an ectopic source is an uncommon condition, accounting for 4–5% of all cases of CS. Refractory hypokalemia can be the presenting feature in patients with ectopic ACTH syndrome (EAS), and is seen in up to 80% of cases. EAS can be rapidly progressive and life-threatening without timely diagnosis and intervention.

https://cushingsbios.com/2025/12/16/final-diagnosis-acth-dependent-cushings-syndrome-ectopic-acth-syndrome/

Dee (Dee), Pituitary Bio

Sun, 17 May 2026 05:00:00 EST

(Sun, 17 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 17 May 2026 06:00:00 EST

(Sun, 17 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Hormones and High Blood Pressure: Study Reveals Endocrine Culprits and Targeted Treatments

Sun, 17 May 2026 06:00:00 EST

(Sun, 17 May 2026 )

CS is treated through surgical procedures based on the detected lesions. Patients with severe CS are treated with steroidogenic inhibitors, such as metyrapone, ketoconazole, osilodrostat, and mitotane. Pituitary radiotherapy and bilateral adrenalectomy are performed when other treatments are not effective.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 17 May 2026 07:00:00 EST

(Sun, 17 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Spreading the Word

Sun, 17 May 2026 08:00:00 EST

(Sun, 17 May 2026 )

I had the opportunity to be in both Fair Oaks Emergency Room and the hospital in Fairfax, VA over the last couple days. Whenever a nurse/medical tech mentioned steroids, I asked what they knew about Cushing's. One asked if it was a medication. DUH!…

Prevalence and Associated Risk Factors for Venous Thromboembolism in a Large Cohort of Patients With Cushing Disease

Sun, 17 May 2026 08:00:00 EST

(Sun, 17 May 2026 )

Endogenous Cushing syndrome is associated with an intrinsic hypercoagulable state and an increased risk of venous thromboembolism (VTE). This study aimed to determine the prevalence and risk factors for VTE in a large cohort of patients with Cushing disease (CD).

https://cushings.invisionzone.com/topic/57917-prevalence-and-associated-risk-factors-for-venous-thromboembolism-in-a-large-cohort-of-patients-with-cushing-disease/

Insulin Resistance Unveiled: Cushing's Disease in a Patient with Type 1 Diabetes Mellitus and Worsening Glycemic Control

Sun, 17 May 2026 08:00:00 EST

(Sun, 17 May 2026 )

Type 1 diabetes mellitus is an autoimmune disease often characterized by endogenous insulin deficiency and often sensitivity to endogenous insulin administration. Cushing's disease, though rare, should be considered as a cause of insulin resistance and increased insulin requirements in individuals with type 1 diabetes mellitus.

https://cushings.invisionzone.com/topic/57942-insulin-resistance-unveiled-cushings-disease-in-a-patient-with-type-1-diabetes-mellitus-and-worsening-glycemic-control/

Transsphenoidal Surgery in an Older Patient with Cushing's Disease

Sun, 17 May 2026 09:00:00 EST

(Sun, 17 May 2026 )

Cushing's disease causes numerous metabolic disorders, cognitive decline, and sarcopenia, leading to deterioration of the general health in older individuals. Cushing's disease can be treated with transsphenoidal surgery, but thus far, surgery has often been avoided in older patients.

Repeat Endoscopic Endonasal Transsphenoidal Surgery for Residual or Recurrent Cushing's Disease: Safety, Feasibility, and Success

Sun, 17 May 2026 10:00:00 EST

(Sun, 17 May 2026 )

The success and outcomes of repeat endoscopic transsphenoidal surgery (ETS) for residual or recurrent Cushing's disease (CD) are underreported in the literature. This study aims to address this gap by assessing the safety, feasibility, and efficacy of repeat ETS in these patients.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 17 May 2026 10:00:00 EST

(Sun, 17 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 17 May 2026 11:00:00 EST

(Sun, 17 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Understanding Cortisol: The Stress Hormone Explained

Sun, 17 May 2026 12:00:00 EST

(Sun, 17 May 2026 )

Cortisol testing is not routinely done during medical check-ups, and there currently aren’t any at-home tests available to assess cortisol levels. Most healthcare providers only recommend testing for cortisol if there are symptoms indicative of conditions like Cushing’s syndrome.

https://cushings.invisionzone.com/topic/57776-understanding-cortisol-the-stress-hormone-explained/

Paediatric Cushing Syndrome: Prospective, Multisite, Observational Cohort Study

Sun, 17 May 2026 15:00:00 EST

(Sun, 17 May 2026 )

Paediatric endogenous Cushing syndrome is a rare condition with variable signs and symptoms of presentation. We studied a large cohort of paediatric patients with endogenous Cushing syndrome with the aim of describing anthropometric, clinical, and biochemical characteristics as well as associated complications and outcomes to aid diagnosis, treatment, and management.

Evaluating the usefulness of plasma chromogranin A measurement in cyclic ACTH-dependent Cushing’s syndrome

Sun, 17 May 2026 22:00:00 EST

(Sun, 17 May 2026 )

Cushing’s syndrome, a clinical condition characterized by hypercortisolemia, exhibits distinct clinical signs and is associated with cyclic cortisol secretion in some patients. The clinical presentation of cyclic Cushing’s syndrome can be ambiguous and its diagnosis is often challenging.

Clinical Features and Treatment Options for Pediatric Adrenal Incidentalomas

Mon, 18 May 2026 03:00:00 EST

(Mon, 18 May 2026 )

Cortical tumors are particularly rare among children with AIs and are sometimes not clearly distinguishable from neurogenic tumors on preoperative imaging; in such patients, the presence of subclinical Cushing’s syndrome needs to be carefully evaluated preoperatively; otherwise, a perioperative adrenal crisis may occur [21]. In patients in whom the possibility of an adrenocortical tumor was considered preoperatively, the assessment for subclinical Cushing’s syndrome mainly involved assessing the serum dehydroepiandrosterone sulfate level and performing an overnight dexamethasone suppression test.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Mon, 18 May 2026 03:00:00 EST

(Mon, 18 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

A Case of Recurrent Cushing’s Disease With Optimised Perinatal Outcomes

Mon, 18 May 2026 03:00:00 EST

(Mon, 18 May 2026 )

This is a case of a patient with a 10-year history of Cushing’s disease (CD) that was previously treated with transsphenoidal pituitary tumour resection. Conception occurred spontaneously, and during early pregnancy recurrent CD became apparent both clinically and biochemically.

https://cushings.invisionzone.com/topic/57928-approach-to-the-patient-with-cushing’s-syndrome-use-of-anticoagulation-therapy/

Obesity-Related Hemodynamic Alterations in Patients with Cushing’s Disease

Mon, 18 May 2026 04:00:00 EST

(Mon, 18 May 2026 )

Cushing’s disease (CD) is associated with a specific form of metabolic syndrome that includes visceral obesity, which may affect cardiovascular hemodynamics by stimulating hypercortisolism-related metabolic activity. The purpose of this study was to evaluate the relationship between obesity and the hemodynamic profile of patients with CD.

Basics: What is Cushing's disease?

Mon, 18 May 2026 05:00:00 EST

(Mon, 18 May 2026 )

Blood tests and an MRI confirmed that Yawn had a tumour in her pituitary gland — a small, pea-sized organ at the base of the brain — that caused the gland to release excess adrenocorticotropic hormones. As a result, she became inundated with cortisol, a steroid the body releases in response to danger or stress. This combination of factors led to her diagnosis — Cushing’s disease.https://cushings.invisionzone.com/topic/57014-basics-what-is-cushings-disease/

Consecutive Resections of Double Pituitary Adenoma for Resolution of Cushing Disease

Mon, 18 May 2026 05:00:00 EST

(Mon, 18 May 2026 )

Double pituitary adenomas are rare presentations of two distinct adenohypophyseal lesions seen in <1% of surgical cases. Increased rates of recurrence or persistence are reported in the resection of Cushing microadenomas and are attributed to the small tumor size and localization difficulties.

Predictors of Cancer in Patients With Endogenous Cushing’s Syndrome

Mon, 18 May 2026 05:00:00 EST

(Mon, 18 May 2026 )

Prolonged cortisol exposure may promote cancer development and growth. Epidemiological research showed that extended glucocorticoids use is associated with elevated overall cancer risk. Recently, several studies suggested that cortisol levels increase cancer risk in patients with endogenous Cushing’s syndrome (CS).

https://cushings.invisionzone.com/topic/57854-predictors-of-cancer-in-patients-with-endogenous-cushing%E2%80%99s-syndrome/

Dee (Dee), Pituitary Bio

Mon, 18 May 2026 05:00:00 EST

(Mon, 18 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Mon, 18 May 2026 06:00:00 EST

(Mon, 18 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Mon, 18 May 2026 07:00:00 EST

(Mon, 18 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

How AI Could Help Make Brain Surgery Safer

Mon, 18 May 2026 07:00:00 EST

(Mon, 18 May 2026 )

The AI system analyzed video of more than 200 pituitary gland tumor operations, and gained around 10 years-worth of experience in a fraction of the time.

Severe McCune–Albright Syndrome Presenting with Neonatal Cushing Syndrome: Navigating Through Clinical Obstacles

Mon, 18 May 2026 08:00:00 EST

(Mon, 18 May 2026 )

Café-au-lait skin macules, Cushing syndrome (CS), hyperthyroidism, and liver and cardiac dysfunction are presenting features of neonatal McCune–Albright syndrome (MAS), CS being the rarest endocrine feature. Although spontaneous resolution of hypercortisolism has been reported, outcome is usually unfavorable. While a unified approach to diagnosis, treatment, and follow-up is lacking, herein successful treatment and long-term follow-up of a rare case is presented.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Mon, 18 May 2026 08:00:00 EST

(Mon, 18 May 2026 )

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Mon, 18 May 2026 10:00:00 EST

(Mon, 18 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Interpetrosal Sphingosine-1-Phosphate Ratio Predicting Cushing’s Disease Tumor Laterality and Remission After Surgery

Mon, 18 May 2026 11:00:00 EST

(Mon, 18 May 2026 )

Cushing’s disease (CD) poses significant challenges in its treatment due to the lack of reliable biomarkers for predicting tumor localization or postoperative clinical outcomes. Sphingosine-1-phosphate (S1P) has been shown to increase cortisol biosynthesis and is regulated by adrenocorticotropic hormone (ACTH).

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Mon, 18 May 2026 11:00:00 EST

(Mon, 18 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

New Advances For Treating Complex Pituitary Tumors

Mon, 18 May 2026 15:00:00 EST

(Mon, 18 May 2026 )

Pituitary tumors can vary widely in severity, with some requiring surgical intervention. While certain pituitary tumors are more straightforward to remove, those that extend beyond the medial wall of the cavernous sinus (MWCS) are considered complex. A delicate region near the pituitary gland, the MWCS contains critical structures like cranial nerves and the carotid artery, which present additional surgical challenges.

https://cushings.invisionzone.com/topic/57830-new-advances-for-treating-complex-pituitary-tumors/

Add or update Your Bio

Tue, 19 May 2026 01:00:00 EST

(Tue, 19 May 2026 )

Please add your bio. Your information will help others.

Cushing's World Map

Tue, 19 May 2026 01:00:00 EST

(Tue, 19 May 2026 )

Add your location and diagnosis to our Cushing's World Map.
Helpful Doctor locations are being added to this map, as well

See the Map at https://drive.google.com/open?id=1NLdGqTJyaJOvxegUnUR_slLRcYyMsVbJ&usp=sharing

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Tue, 19 May 2026 03:00:00 EST

(Tue, 19 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dee (Dee), Pituitary Bio

Tue, 19 May 2026 05:00:00 EST

(Tue, 19 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Tue, 19 May 2026 06:00:00 EST

(Tue, 19 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

A Prospective Trial With Ketoconazole Induction Therapy and Octreotide Maintenance Treatment for Cushing's Disease

Tue, 19 May 2026 06:00:00 EST

(Tue, 19 May 2026 )

Sequential treatment with ketoconazole to lower cortisol levels followed by octreotide to maintain biochemical remission according to UFC may be effective in a subset of patients with mild Cushing's Disease, suggesting that cortisol-mediated suppression of SST2 expression is a reversible process.

https://cushings.invisionzone.com/topic/57843-a-prospective-trial-with-ketoconazole-induction-therapy-and-octreotide-maintenance-treatment-for-cushings-disease/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Tue, 19 May 2026 07:00:00 EST

(Tue, 19 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Pituitary Tumors and Treatments

Tue, 19 May 2026 08:00:00 EST

(Tue, 19 May 2026 )

Pituitary tumors start in the pituitary gland. They’re usually benign (not cancerous) and rarely spread to other parts of the body. Dr. Borghei-Razavi discusses pituitary tumors and treatments through minimally invasive surgical approaches offered at Cleveland Clinic Florida.

New Helpful Endo in Tennessee?

Tue, 19 May 2026 08:00:00 EST

(Tue, 19 May 2026 )

CHI Memorial Medical Group announces the opening of CHI Memorial Endocrinology Associates, a practice that provides comprehensive medical management and care for conditions like type 1 and 2 diabetes, thyroid disease, thyroid cancer and a range of metabolic, pituitary and adrenal disorders.

The practice will be led by Prashanth Sekhar, MD, a fellowship trained endocrinologist with more than 10 years’ experience helping individuals with hormone-related conditions and diseases.

Planning for Surgery? You Might Not Need All Those Tests Beforehand

Tue, 19 May 2026 09:00:00 EST

(Tue, 19 May 2026 )

Doctors delayed the surgery until he got a CT scan, which did not confirm a lung nodule but did find one on an adrenal gland. Again, doctors postponed surgery to allow for further work-up of the adrenal nodule, which was ultimately found to be benign. The man finally had his hernia repaired after six additional months of debilitating pain and repeated anxiety over incidental test findings suggesting he could have cancer.

From https://www.nytimes.com/2021/11/15/well/live/surgery-medical-tests.html

Longterm-Outcomes In Patients With Cushing’s Disease vs. Non-Functioning Pituitary Adenoma After Pituitary Surgery: An Active-Comparator Cohort Study

Tue, 19 May 2026 10:00:00 EST

(Tue, 19 May 2026 )

Even after pituitary surgery, Cushing's Disease patients faced a higher hazard of complications, especially psychiatric hospitalizations and sepsis.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Tue, 19 May 2026 10:00:00 EST

(Tue, 19 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Tue, 19 May 2026 11:00:00 EST

(Tue, 19 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Need Financial Assistance?

Tue, 19 May 2026 14:00:00 EST

(Tue, 19 May 2026 )

Cushing’s Syndrome | Accepting Applications

Medical Assistance
Co-Pay Assistance
Premium Assistance

Giving Thanks: Day Nineteen

Tue, 19 May 2026 15:00:00 EST

(Tue, 19 May 2026 )

I am thankful, believe it or not, that I had Cushing’s. Mind you, I wouldn’t want to have it now, although diagnoses and surgeries seem “easier” now.

Having Cushing’s taught me a lot, including how to stick up for myself, how to read medical books to learn more about my disease, how to do web design, how to navigate NIH. It taught me patience, how to make phone calls. It brought me a lot of new friends.

Read more at https://www.maryo.co/giving-thanks-day-19-2/

Thin Skin in Cushing’s Syndrome

Tue, 19 May 2026 16:00:00 EST

(Tue, 19 May 2026 )

A 53-year-old woman with a history of metastatic small-cell lung cancer was evaluated during an inpatient admission for Cushing’s syndrome on the basis of new findings of hypertension, hypokalemia, hyperglycemia, and metabolic alkalosis.

https://cushings.invisionzone.com/topic/57798-thin-skin-in-cushing%E2%80%99s-syndrome/

Adrenal Insufficiency May Be Misdiagnosed as Anxiety

Wed, 20 May 2026 03:00:00 EST

(Wed, 20 May 2026 )

The hormone cortisol is produced by the adrenal glands, so adrenal insufficiency (also called Addison’s disease) is caused when the adrenal glands do not produce cortisol normally. Low cortisol can actually cause anxiety and depression, so some patients may really have anxiety — though doctors need to do further testing and/or evaluation to see that it is caused by their hormone levels, not a mental illness.

https://cushings.invisionzone.com/topic/57767-adrenal-insufficiency-may-be-misdiagnosed-as-anxiety/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Wed, 20 May 2026 03:00:00 EST

(Wed, 20 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

From Reader's Digest!

Wed, 20 May 2026 05:00:00 EST

(Wed, 20 May 2026 )

The February 2022 issue of Reader's Digest has information about a pituitary Cushing's patient.

Read the article at https://cushings.invisionzone.com/topic/56500-from-this-months-readers-digest/

First-of-its Kind Hormone Replacement Treatment Shows Promise in Patient Trials

Wed, 20 May 2026 05:00:00 EST

(Wed, 20 May 2026 )

The new 'pulsatility' therapy, the culmination of ten years' research by the Bristol team, is designed to deliver standard hydrocortisone replacement to patients via a pump which replicates more closely cortisol's natural rhythmic secretion pattern. The pulsatile subcutaneous pump has now revealed promising results in its first clinical trial.

Dee (Dee), Pituitary Bio

Wed, 20 May 2026 05:00:00 EST

(Wed, 20 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Wed, 20 May 2026 06:00:00 EST

(Wed, 20 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Wed, 20 May 2026 07:00:00 EST

(Wed, 20 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Basics: Cushing's Syndrome vs. Cushing's Disease

Wed, 20 May 2026 08:00:00 EST

(Wed, 20 May 2026 )

Any condition that causes the adrenal gland to produce excessive cortisol results in the disorder Cushing's syndrome. Cushing syndrome is characterized by facial and torso obesity, high blood pressure, stretch marks on the belly, weakness, osteoporosis, and facial hair growth in females.

Surgical Remission of Cushing's Disease Tied to New Autoimmune Conditions

Wed, 20 May 2026 08:00:00 EST

(Wed, 20 May 2026 )

Development of autoimmune disease was more common in patients with surgical remission of Cushing's disease than in those with surgically treated nonfunctioning pituitary adenomas (NFPAs), according to a retrospective matched cohort study.

Olfactory Neuroblastoma Causing Cushing’s Syndrome Due to the Ectopic Adrenocorticotropic Hormone (ACTH) Secretion

Wed, 20 May 2026 09:00:00 EST

(Wed, 20 May 2026 )

Venous Thromboembolism in Cushing Syndrome

Wed, 20 May 2026 10:00:00 EST

(Wed, 20 May 2026 )

Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism.

Targeted analysis of Ubiquitin-Specific Peptidase (USP8) in a population of Iranian people with Cushing’s disease and a systematic review of the literature

Wed, 20 May 2026 10:00:00 EST

(Wed, 20 May 2026 )

Pituitary corticotroph adenoma accounts for 68% of endogenous hypercortisolism. Prolonged exposure to high cortisol levels is associated with a variety of long-term complications, impaired quality of life, and increased mortality. Transsphenoidal surgical excision is the treatment of choice. However, curative surgery is challenging with the initial remission rate of 65–85% and a high recurrence rate.

From https://cushings.invisionzone.com/topic/57747-targeted-analysis-of-ubiquitin-specific-peptidase-usp8-in-a-population-of-iranian-people-with-cushing%E2%80%99s-disease-and-a-systematic-review-of-the-literature/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Wed, 20 May 2026 10:00:00 EST

(Wed, 20 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

High Prevalence of Adrenal Imaging Abnormalities in Cushing’s Disease

Wed, 20 May 2026 10:00:00 EST

(Wed, 20 May 2026 )

We identified abnormal adrenal imaging in 51.5% of patients with CD. The prevalence of adrenal nodules in our study was 10-fold higher than in the normal population, for all age groups. This suggests that chronic ACTH secretion in Cushing's Disease is associated with adrenal nodules appearance.

https://cushings.invisionzone.com/topic/57881-high-prevalence-of-adrenal-imaging-abnormalities-in-cushing’s-disease/

What Causes Blood Sugar to Rise in Non-Diabetics?

Wed, 20 May 2026 11:00:00 EST

(Wed, 20 May 2026 )

People with Cushing’s syndrome are at an increased risk of developing impaired glucose tolerance and hyperglycemia as a result of increased levels of cortisol throughout the body…

Approximately 10% to 30% of people with Cushing’s syndrome will develop impaired glucose tolerance, while 40% to 45% will develop diabetes.

Helpful Doctors: Wisconsin

Wed, 20 May 2026 11:00:00 EST

(Wed, 20 May 2026 )

“My absolute favorite MD. Dr. Maas gets to know her patients and is very thorough. Dr. Maas gave me my life back and I will always love her for that. If you want a great Endocrinologist, she’s your best bet.” – Veronica M.

Can We Predict the Risk of Venous Thromboembolism in Patients With Cushing’s Syndrome

Wed, 20 May 2026 11:00:00 EST

(Wed, 20 May 2026 )

Patients with Cushing’s syndrome (CS) have an increased venous thromboembolism (VTE) risk with most studies focusing on the perioperative period. The purpose of this study was to assess the 5-year VTE risk and identify predictors of VTE at CS diagnosis.

https://cushings.invisionzone.com/topic/57777-can-we-predict-the-risk-of-venous-thromboembolism-in-patients-with-cushing%E2%80%99s-syndrome/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Wed, 20 May 2026 11:00:00 EST

(Wed, 20 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Bone Material Strength index is low in Patients with Cushing's Syndrome even after long-term remission

Wed, 20 May 2026 12:00:00 EST

(Wed, 20 May 2026 )

Bone material properties remain altered in patients with endogenous Cushing's Syndrome, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.

https://cushings.invisionzone.com/topic/57768-bone-material-strength-index-is-low-in-patients-with-cushings-syndrome-even-after-long-term-remission/

The Neurosurgical Outcome of Pediatric Cushing’s Disease in a Single Center From China: A 20-Year Experience

Wed, 20 May 2026 12:00:00 EST

(Wed, 20 May 2026 )

Transsphenoidal surgery represents a highly effective first-line treatment for pediatric CD, achieving high rates of immediate (90.9%) and long-term remission (81.8%) in a specialized center. A meticulous diagnostic approach incorporating BIPSS is crucial, particularly for MRI-negative cases. While recurrence occurred in a minority of patients, primarily those with microadenomas, durable disease control is attainable for the majority with appropriate surgical management. The transition to endoscopic techniques was feasible and effective.

https://cushings.invisionzone.com/topic/57885-the-neurosurgical-outcome-of-pediatric-cushing%E2%80%99s-disease-in-a-single-center-from-china-a-20-year-experience/

From Knee Pain Consultation to Pituitary Surgery: The Challenge of Cushing Disease Diagnosis

Thu, 21 May 2026 02:00:00 EST

(Thu, 21 May 2026 )

We present the case of a 66-year-old female patient who received a referral to endocrinology for an evaluation of obesity due to right knee arthropathy. Taking into consideration her age, she was screened for osteoporosis, with results that showed diminished bone density. Considering this, combined with other clinical features of the patient, suspicion turned toward hypercortisolism. Laboratory findings suggested that the CS was ACTH-dependent and originated in the pituitary gland.

After a second look at the magnetic resonance imaging results, a 4-mm lesion was identified on the pituitary gland, prompting a transsphenoidal resection of the pituitary adenoma.

The Reflex Dexamethasone Suppression Test: Development and Assessment of Reflexed Serum Dexamethasone Measurement for the Diagnosis of Cushing Syndrome

Thu, 21 May 2026 03:00:00 EST

(Thu, 21 May 2026 )

Screening for Cushing syndrome (CS; endogenous overproduction of ACTH or cortisol) is performed by the low-dose overnight serum dexamethasone suppression test (oDST) with the measurement of serum dexamethasone concentration to assure an effective dose.

https://cushings.invisionzone.com/topic/57865-the-reflex-dexamethasone-suppression-test-development-and-assessment-of-reflexed-serum-dexamethasone-measurement-for-the-diagnosis-of-cushing-syndrome/

Severe Psychosis Due to Cushing Syndrome

Thu, 21 May 2026 03:00:00 EST

(Thu, 21 May 2026 )

Cushing syndrome (CS) is a rare clinical condition resulting in excess cortisol production. Neuropsychiatric disturbances are prevalent, in addition to the well-known metabolic effects. Depression and anxiety are the most common manifestations, while mania and psychosis are rare.1,2 We report the case of a patient who presented with severe psychosis due to adrenocorticotropic hormone (ACTH)–dependent CS due to a pituitary adenoma (PA).

https://cushings.invisionzone.com/topic/57866-severe-psychosis-due-to-cushing-syndrome/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Thu, 21 May 2026 03:00:00 EST

(Thu, 21 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Shagufta, Pituitary Recurrence

Thu, 21 May 2026 04:00:00 EST

(Thu, 21 May 2026 )

Shagufta is a Cushings survivor - post pituitary surgery 20 years ago. Cushing's came back in 2008 after three surgeries. Was put on medication until 2012 when s/he had gamma knife radiotherapy. Still has health issues...

High Recovery Rate of Adrenal Function After Successful Surgical Treatment of Cushing’s Syndrome

Thu, 21 May 2026 04:00:00 EST

(Thu, 21 May 2026 )

The recovery rate of adrenal function after successful surgery as first-line treatment in patients with Cushing’s syndrome is high. However, it may take several months to years before recovery of adrenal function occurs. In case of early recovery of adrenal function, clinicians should be aware of a possible recurrence of Cushing’s disease.

https://cushings.invisionzone.com/topic/57814-high-recovery-rate-of-adrenal-function-after-successful-surgical-treatment-of-cushing%E2%80%99s-syndrome/

Ectopic Cushing’s Syndrome From a Corticotropin-Releasing Hormone-Secreting Medullary Thyroid Carcinoma: a Rare Pitfall af Inferior Petrosal Sinus Sampling

Thu, 21 May 2026 05:00:00 EST

(Thu, 21 May 2026 )

This case shows that Cushing’s Syndrome (CS) caused by ectopic corticotropin-releasing hormone (CRH) secretion may masquerade as CS due to a false positive inferior petrosal sinus sampling test (IPSS) test. It also highlights the importance of considering rare causes of CS when diagnostic test results are ambiguous.

Dee (Dee), Pituitary Bio

Thu, 21 May 2026 05:00:00 EST

(Thu, 21 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Thu, 21 May 2026 06:00:00 EST

(Thu, 21 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Prospective Assessment of Mood and Quality of Life in Cushing Syndrome Before and After Biochemical Control

Thu, 21 May 2026 06:00:00 EST

(Thu, 21 May 2026 )

Cushing’s syndrome (CS) impairs quality of life (QoL) and mood. Prospective real-life data on posttreatment recovery and predictors of improvement are limited.

https://cushings.invisionzone.com/topic/57918-prospective-assessment-of-mood-and-quality-of-life-in-cushing-syndrome-before-and-after-biochemical-control/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Thu, 21 May 2026 07:00:00 EST

(Thu, 21 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Valrie, Pituitary News Item

Thu, 21 May 2026 09:00:00 EST

(Thu, 21 May 2026 )

HOUR-LONG seizures, vision loss in the right eye, and failure to complete sentences are among the challenges that 54-year-old Valrie Anderson has been battling for the last 20 years.

These problems stem from a condition called pituitary adenoma, which is a growth or tumour on the pituitary gland in the brain.

Challenges of Cushing's Syndrome and Bariatric Surgery

Thu, 21 May 2026 10:00:00 EST

(Thu, 21 May 2026 )

Cushing’s disease (CD), caused by an adrenocorticotropic hormone-secreting pituitary adenoma, is challenging to diagnose, especially in obese patients post-bariatric surgery.

This report discusses a misdiagnosed case of CD in a 42-year-old obese male with hypertension. CD was suspected only after surgery, confirmed by magnetic resonance imaging (MRI) showing a pituitary macroadenoma.

https://cushings.invisionzone.com/topic/57844-challenges-of-cushings-syndrome-and-bariatric-surgery/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Thu, 21 May 2026 10:00:00 EST

(Thu, 21 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Thu, 21 May 2026 11:00:00 EST

(Thu, 21 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Basics: Pituitary Tumors and Headaches

Thu, 21 May 2026 18:00:00 EST

(Thu, 21 May 2026 )

Headaches are a common complaint in patients with pituitary tumors. Although many patients presumably have headaches which are unrelated to their pituitary tumor, there are several important direct and indirect mechanisms by which pituitary tumors may elicit or exacerbate headaches. Pituitary tumors may directly provoke headaches by eroding laterally into the cavernous sinus, which contains the first and second divisions of the trigeminal nerve, by involvement of the dural lining of the sella or diaphragma sella (which are innervated by the trigeminal nerve), or via sinusitis, particularly after transsphenoidal surgery.

Osilodrostat Treatment of Cushing Syndrome in Real-World Clinical Practice

Thu, 21 May 2026 19:00:00 EST

(Thu, 21 May 2026 )

In clinical trials, osilodrostat (11β-hydroxylase inhibitor) effectively reduced cortisol levels in patients with endogenous Cushing syndrome (CS).

https://cushings.invisionzone.com/topic/57831-osilodrostat-treatment-of-cushing-syndrome-in-real-world-clinical-practice/

Cushing Syndrome due to a CRH- and ACTH-Secreting Silent Pheochromocytoma

Fri, 22 May 2026 02:00:00 EST

(Fri, 22 May 2026 )

Ectopic co-secretion of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) in silent (i.e., noncatecholamine-secreting) pheochromocytoma is a rare cause of Cushing Syndrome (CS).

Etomidate in the Treatment Of Cushing Syndrome

Fri, 22 May 2026 03:00:00 EST

(Fri, 22 May 2026 )

Cushing syndrome is a metabolic disease caused by chronic exposure to high levels of glucocorticoids. It can present as an endocrine emergency due to a rapid increase in circulating cortisol leading to increased risk of cardiovascular disease and infection. Etomidate rapidly reduces plasma cortisol levels by inhibiting the action of 11β-hidroxilase. We report the case of a patient with severe hypercortisolaemia accompanied by metabolic and psychiatric disorders in whom administration of etomidate reduced preoperative levels of cortisol.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Fri, 22 May 2026 03:00:00 EST

(Fri, 22 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Cushing Disease Clinical Phenotype and Tumor Behavior Vary With Age

Fri, 22 May 2026 05:00:00 EST

(Fri, 22 May 2026 )

There are age-dependent differences in clinical presentation, tumor behavior, and postoperative outcomes in patients with Cushing's Disease. Compared to younger patients, older patients present with a less classic phenotype characterized by fewer hallmark features, more medical comorbidities, and larger tumors.

https://cushings.invisionzone.com/topic/57778-cushing-disease-clinical-phenotype-and-tumor-behavior-vary-with-age/

Dee (Dee), Pituitary Bio

Fri, 22 May 2026 05:00:00 EST

(Fri, 22 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Is it Possible to Have Coexisting Exogenous and Endogenous Cushing's Syndrome?

Fri, 22 May 2026 05:00:00 EST

(Fri, 22 May 2026 )

A 40-year-old female patient, hypertensive for three months and treated with 5 mg of amlodipine, with newly diagnosed untreated diabetes mellitus, presented to the emergency department with severe asthenia, abdominal pain, and vomiting. The medical history revealed prolonged self-medication with dexamethasone at a dose of 1 mg/day for three years in order to gain weight. The patient reported having ceased this corticosteroid therapy 10 days prior to presentation.

https://cushings.invisionzone.com/topic/57960-is-it-possible-to-have-coexisting-exogenous-and-endogenous-cushings-syndrome/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Fri, 22 May 2026 06:00:00 EST

(Fri, 22 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Fri, 22 May 2026 07:00:00 EST

(Fri, 22 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Adrenocorticotropin-Dependent Ectopic Cushing's Syndrome: A Case Report

Fri, 22 May 2026 07:00:00 EST

(Fri, 22 May 2026 )

The diagnosis of Cushing's Syndrome is a three-step process that includes its suspicion based on the patient's laboratory and semiologic findings, the documentation of hypercortisolism, and the identification of its cause, which can be either ACTH-dependent or independent.

Management of Diabetes Mellitus in Acromegaly and Cushing’s Disease with Focus on Pasireotide Therapy

Fri, 22 May 2026 08:00:00 EST

(Fri, 22 May 2026 )

Patients suffering from acromegaly and Cushing’s Disease (CD) face the risk of several clinical complications. The onset of diabetes mellitus (DM) is among the most important: exposure to elevated growth hormone or cortisol levels is associated with insulin resistance (IR).

High-resolution Contrast-enhanced MRI With Three-Dimensional Fast Spin Echo Improved the Diagnostic Performance for Identifying Pituitary Microadenomas In Cushing’s Syndrome

Fri, 22 May 2026 09:00:00 EST

(Fri, 22 May 2026 )

The diagnostic performance of hrMRI was higher than cMRI and dMRI for identifying pituitary microadenomas in Cushing’s syndrome.

About 80% of patients, who were misdiagnosed on cMRI and dMRI, were correctly diagnosed on hrMRI.

Different Patient Versus Provider Perspectives on Living with Cushing’s Disease

Fri, 22 May 2026 09:00:00 EST

(Fri, 22 May 2026 )

Patients with Cushing’s disease (CD) face challenges living with and receiving appropriate care for this rare, chronic condition. Even with successful treatment, many patients experience ongoing symptoms and impaired quality of life (QoL). Different perspectives and expectations between patients and healthcare providers (HCPs) may also impair well-being.

Unveiling the Uncommon: Cushing’s Syndrome (CS) Masquerading as Severe Hypokalemia

Fri, 22 May 2026 10:00:00 EST

(Fri, 22 May 2026 )

This case report presents an unusual manifestation of CS in a 48-year-old male with a history of hypertension, where severe hypokalemia was the primary presentation.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Fri, 22 May 2026 10:00:00 EST

(Fri, 22 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Enhanced Radiological Detection of a Corticotroph Adenoma Following Treatment With Osilodrostat

Fri, 22 May 2026 10:00:00 EST

(Fri, 22 May 2026 )

We describe a 42-year-old woman with Cushing disease, in whom MRI findings at presentation were equivocal with no clear adenoma visualized. She was initially treated with metyrapone, which resulted in partial biochemical control of hypercortisolism. After switching to osilodrostat, there was a marked improvement in her symptoms and rapid normalization of cortisol levels.

https://cushings.invisionzone.com/topic/57903-enhanced-radiological-detection-of-a-corticotroph-adenoma-following-treatment-with-osilodrostat/

Real-World Osilodrostat Effectiveness and Safety in Non-Pituitary Cushing Syndrome

Fri, 22 May 2026 10:00:00 EST

(Fri, 22 May 2026 )

Osilodrostat is a suitable treatment for endogenous Cushing syndrome of various non-pituitary etiologies.

https://cushings.invisionzone.com/topic/57919-real-world-osilodrostat-effectiveness-and-safety-in-non-pituitary-cushing-syndrome/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Fri, 22 May 2026 11:00:00 EST

(Fri, 22 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Therapeutic Options for the Prevention of Thromboses in Cushing’s Syndrome

Fri, 22 May 2026 11:00:00 EST

(Fri, 22 May 2026 )

Cushing’s syndrome, or hypercortisolism, occurs after prolonged exposure to excess cortisol, and can be characterized by moon facies, central fat redistribution, proximal limb muscle weakness and wasting, and abdominal striae. Medical literature points to a relationship between hypercortisolism and hypercoagulability, with higher rates of venous thromboembolism noted. Current guidelines recommend prophylaxis with low-molecular weight heparin (LMWH), but there is little evidence to support LMWH over other forms of anticoagulation.

https://cushings.invisionzone.com/topic/57832-therapeutic-options-for-the-prevention-of-thromboses-in-cushing%E2%80%99s-syndrome/

Video: People Don’t Understand Cushing’s Disease

Fri, 22 May 2026 11:00:00 EST

(Fri, 22 May 2026 )

Cushing’s disease changed my body, my mind, and honestly my whole life. The swelling, cortisol, mood swings, pain, exhaustion… people don’t always understand how brutal it can be. This morning one of our viewers shared that they were just diagnosed too, and it hit me hard. So to anybody out there fighting something silently — cancer, Cushing’s, chronic illness, fear, depression, anything… You are NOT alone. We’re praying for you over here.

https://cushingsbios.com/2026/05/22/video-people-dont-understand-cushings-disease/

Higher Risk and Earlier Onset Glaucoma in Cushing's Syndrome

Fri, 22 May 2026 12:00:00 EST

(Fri, 22 May 2026 )

Endogenous Cushing's Syndrome is associated with increased risk for glaucoma regardless of remission status and develops at a younger age compared with the general population.

https://cushings.invisionzone.com/topic/57769-higher-risk-and-earlier-onset-glaucoma-in-cushings-syndrome/

Dynamic Functional Connectivity Changes Associated with Psychiatric Traits and Cognitive Deficits in Cushing’s Disease

Fri, 22 May 2026 18:00:00 EST

(Fri, 22 May 2026 )

Cushing’s disease is a rare neuroendocrine disorder with excessive endogenous cortisol, impaired cognition, and psychiatric symptoms. Evidence from resting-state fMRI revealed the abnormalities of static brain connectivity in patients with Cushing’s disease (CD patients).

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sat, 23 May 2026 03:00:00 EST

(Sat, 23 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Basics 911! Adrenal Crisis, Addison’s/Adrenal Insufficiency

Sat, 23 May 2026 03:00:00 EST

(Sat, 23 May 2026 )

Adrenal crisis occurs if the adrenal gland is deteriorating (Addison’s disease, primary adrenal insufficiency), if there is pituitary gland injury (secondary adrenal insufficiency), or if adrenal insufficiency is not adequately treated. Risk factors for adrenal crisis include physical stress such as infection, dehydration, trauma, or surgery, adrenal gland or pituitary gland injury, and ending treatment with steroids such as prednisone or hydrocortisone too early.

https://cushieblogger.com/2025/11/22/basics-911-adrenal-crisis-addisons-adrenal-insufficiency/

Dee (Dee), Pituitary Bio

Sat, 23 May 2026 05:00:00 EST

(Sat, 23 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sat, 23 May 2026 06:00:00 EST

(Sat, 23 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Relacorilant and Cardiometabolic Outcomes

Sat, 23 May 2026 06:00:00 EST

(Sat, 23 May 2026 )

New data on relacorilant (Corcept Therapeutics), a selective glucocorticoid receptor modulator, revealed several cardiometabolic benefits for patients with hypercortisolism.

Researchers presented results from the GRACE and GRADIENT trials, which assessed relacorilant in adults with hypercortisolism. GRACE was an open-label trial that enrolled adults with endogenous hypercortisolism, whereas GRADIENT included those with adrenal hypercortisolism and randomly assigned participants to relacorilant or placebo.

https://cushings.invisionzone.com/topic/57883-relacorilant-and-cardiometabolic-outcomes/

Janet (janetelizabeth), Adrenal Bio

Sat, 23 May 2026 06:00:00 EST

(Sat, 23 May 2026 )

I have recently been diagnosed with cushings syndrome and awaiting removal of gland and tumour.

https://cushingsbios.com/2025/11/07/janet-janetelizabeth-adrenal-bio/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sat, 23 May 2026 07:00:00 EST

(Sat, 23 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Sat, 23 May 2026 08:00:00 EST

(Sat, 23 May 2026 )

Medium and Long-Term Data from a Series of 96 Endoscopic Transsphenoidal Surgeries for Cushing Disease

Sat, 23 May 2026 08:00:00 EST

(Sat, 23 May 2026 )

Postoperative data on Cushing’s disease (CD) are equivocal in the literature. These discrepancies may be attributed to different series with different criteria for remission and variable follow-up durations. Additional data from experienced centers may address these discrepancies. In this study, we present the results obtained from 96 endoscopic transsphenoidal surgeries (ETSSs) for CD conducted in a well-experienced center.

Dexamethasone Suppression for 18F-FDG PET/CT to Localize ACTH-Secreting Pituitary Tumors

Sat, 23 May 2026 10:00:00 EST

(Sat, 23 May 2026 )

Currently, magnetic resonance imaging (MRI) is the gold standard for detecting pituitary adenomas. Nevertheless, modern MRI modalities, including dynamic or volumetric sequences, can reliably detect corticotrophic adenomas in 50–90% cases of CD [9,10,11,12]. This indicates that complementary imaging strategies are required to improve the localization of primary lesions in CD.

Improved Noninvasive Diagnostic Evaluations in Treatment-Naïve Adrenocorticotropic Hormone (ACTH)-Dependent Cushing’s Syndrome

Sat, 23 May 2026 10:00:00 EST

(Sat, 23 May 2026 )

In patients with ACTH-dependent Cushing’s syndrome, HDDST + hrMRI, as noninvasive diagnostic evaluations, achieves high diagnostic performance comparable with gold standard (BIPSS), and it is superior to BIPSS in terms of tumor lateralization accuracy.

https://cushings.invisionzone.com/topic/57856-improved-noninvasive-diagnostic-evaluations-in-treatment-na%C3%AFve-adrenocorticotropic-hormone-acth-dependent-cushing%E2%80%99s-syndrome/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sat, 23 May 2026 10:00:00 EST

(Sat, 23 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

CRH Stimulation Test Boosts Cushing Disease Diagnosis

Sat, 23 May 2026 11:00:00 EST

(Sat, 23 May 2026 )

Adding a corticotropin-releasing hormone (CRH) stimulation test immediately following a 2-day low-dose dexamethasone suppression test (LDDST) ― what's known as a Dex-CRH test and was first introduced in 1993 ― identified Cushing disease in 5 of 65 people (7.7%) with a confirmed diagnosis but who had previously shown normal cortisol levels on a conventional LDDST.

Inferior Petrosal Sinus Sampling (IPSS) Tumor Lateralization and The Surgical Treatment of Cushing’s Disease

Sat, 23 May 2026 11:00:00 EST

(Sat, 23 May 2026 )

Limited data suggest that the rate of correct IPSS tumor lateralization may not be positively associated with postoperative remission or cure in patients with Cushing’s disease. These findings bring into question the utility of IPSS tumor lateralization in the context of preoperative planning and surgical approach rather than confirming a pituitary source.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sat, 23 May 2026 11:00:00 EST

(Sat, 23 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Yana, Pituitary Bio

Sat, 23 May 2026 12:00:00 EST

(Sat, 23 May 2026 )

It took Yana Zavros 16 years to get diagnosed with a disorder called Cushing’s disease.

Sixteen years of a demoralizing condition that causes muscle weakness, mood changes, and weight gain, among other symptoms, because the patient’s adrenal glands produce too much of the stress hormone cortisol.

https://cushingsbios.com/2025/05/23/yana-pituitary-bio/

Diagnostic dilemma in Cushing’s syndrome: discrepancy between patient-reported and physician-assessed manifestations

Sat, 23 May 2026 18:00:00 EST

(Sat, 23 May 2026 )

Using the PET/CT Radiotracer [68Ga]Ga-DOTA-mDesmo to Target V1B Receptors and Localize Corticotropinoma in Cushing’s Disease

Sat, 23 May 2026 18:00:00 EST

(Sat, 23 May 2026 )

Cushing’s disease, the most common cause of Cushing’s syndrome, is driven by pituitary tumors (corticotropinoma) and characterized by the overexpression of CRH R1 and V1b receptors. Accurate detection of these tumors remains challenging. This study aims to develop and evaluate a corticotropinoma specific radiopharmaceutical, [68Ga]Ga-DOTA-mDesmo, that targets the V1b receptor for both anatomical and functional identification of corticotropinomas.

https://cushings.invisionzone.com/topic/57867-using-the-petct-radiotracer-68gaga-dota-mdesmo-to-target-v1b-receptors-and-localize-corticotropinoma-in-cushing’s-disease/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 24 May 2026 03:00:00 EST

(Sun, 24 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Co-Occurrence of Endogenous and Exogenous Cushing's Syndromes: Does “Double Cushing Syndrome” Really Exist? A Case Report

Sun, 24 May 2026 05:00:00 EST

(Sun, 24 May 2026 )

Double Cushing syndrome exists: exogenous steroid use can mask concurrent adrenal hypercortisolism. When symptoms persist and cortisol remains high after tapering or stopping prescribed glucocorticoids, an endogenous source is likely. Early recognition with ACTH testing, dexamethasone suppression, and adrenal imaging reduces misdiagnosis, favors timely surgery, and supports safe tapering.

https://cushings.invisionzone.com/topic/57920-co-occurrence-of-endogenous-and-exogenous-cushings-syndromes-does-%E2%80%9Cdouble-cushing-syndrome%E2%80%9D-really-exist-a-case-report/

Dee (Dee), Pituitary Bio

Sun, 24 May 2026 05:00:00 EST

(Sun, 24 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 24 May 2026 06:00:00 EST

(Sun, 24 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 24 May 2026 07:00:00 EST

(Sun, 24 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Evaluation of Ketoconazole As a Treatment for Cushing’s Disease in a Retrospective Cohort

Sun, 24 May 2026 08:00:00 EST

(Sun, 24 May 2026 )

The first-line treatment for Cushing’s disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission. Drug therapies are indicated for patients without initial remission or with surgical contraindications or recurrence, and ketoconazole is one of the main available therapies.

Enhancing Cushing’s disease diagnosis: exploring the impact of desmopressin on ACTH gradient during BIPSS

Sun, 24 May 2026 08:00:00 EST

(Sun, 24 May 2026 )

The differential diagnosis between Cushing’s disease (CD) and ectopic ACTH syndrome (EAS) is complex, and bilateral inferior petrosal sinus sampling (BIPSS) is considered the gold-standard test. However, BIPSS with corticotropin-releasing hormone (CRH) stimulation is rarely available.

Cushing’s Myths and Facts: “You should be all better by now!”

Sun, 24 May 2026 09:00:00 EST

(Sun, 24 May 2026 )

Fact: However, in the case of the chronically ill, a different cycle occurs. In the chronically ill, the person loses his normal health. He goes through a period of treatment and sometimes recovers...

Comment added to Cushing’s Myths and Facts: After a “cure” for Cushing’s, everyone heals and goes back to normal.

Sun, 24 May 2026 09:00:00 EST

(Sun, 24 May 2026 )

Hi my name is Shagufta and I have had Cushings Disease for over 16 years ..Post surgery and still suffering since surgery in 2004/2005.. I was diagnosed in 2004 after suffering and running back and forth to the doctors for over 10 years .. I think my symptoms started in 1990 when I had an early menopause at 24 years old.. I had benign tumour in the Pitituary gland .. Had Pitituary surgery 3 times 2004/2005 before it was successful..

Cushing's Disease Associated With Partially Empty Sella Turcica Syndrome

Sun, 24 May 2026 09:00:00 EST

(Sun, 24 May 2026 )

The association between empty sella turcica (EST) syndrome and Cushing's disease has been rarely reported. It is plausible to hypothesize that EST syndrome in association with Cushing's disease can be attributed to intracranial hypertension

Identification of Endogenous Hypercortisolism and the Effect of Mifepristone Treatment in Patients With Difficult-to-Manage Diabetes: A Case Series

Sun, 24 May 2026 09:00:00 EST

(Sun, 24 May 2026 )

Endogenous hypercortisolism (Cushing syndrome) is a multisystemic disease characterized by a wide range of clinical signs and symptoms. Its heterogeneous presentation can cause significant diagnostic delays, and prolonged exposure to excess cortisol activity can contribute to cardiometabolic abnormalities such as diabetes. When diabetes remains unresponsive or only partially responsive to standard-of-care treatment, clinicians should consider hypercortisolism as a potential underlying driver.

https://cushings.invisionzone.com/topic/57921-identification-of-endogenous-hypercortisolism-and-the-effect-of-mifepristone-treatment-in-patients-with-difficult-to-manage-diabetes-a-case-series/

Global Longitudinal Strain Reduction With Apical Sparing in Cushing Syndrome-Related Heart Failure With Preserved Ejection Fraction (HFpEF): A Case Report

Sun, 24 May 2026 09:00:00 EST

(Sun, 24 May 2026 )

https://cushings.invisionzone.com/topic/57922-global-longitudinal-strain-reduction-with-apical-sparing-in-cushing-syndrome-related-heart-failure-with-preserved-ejection-fraction-hfpef-a-case-report/

Basics: Treatment - Transsphenoidal adenomectomy

Sun, 24 May 2026 10:00:00 EST

(Sun, 24 May 2026 )

The most common procedure to remove pituitary tumors is transsphenoidal adenomectomy. It allows the removal of the tumor with minimal damage to the surrounding structures. The surgical team accesses the pituitary gland through the sphenoid sinus — a hollow space behind the nasal passages and below the pituitary gland.

Repeat Endoscopic Endonasal Transsphenoidal Surgery for Residual or Recurrent Cushing’s Disease: Safety, Feasibility, And Success

Sun, 24 May 2026 10:00:00 EST

(Sun, 24 May 2026 )

The success and outcomes of repeat endoscopic transsphenoidal surgery (ETS) for residual or recurrent Cushing’s disease (CD) are underreported in the literature. This study aims to address this gap by assessing the safety, feasibility, and efficacy of repeat ETS in these patients.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 24 May 2026 10:00:00 EST

(Sun, 24 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 24 May 2026 11:00:00 EST

(Sun, 24 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Altered Microbiome Signature in Cushing’s Syndrome Persists Beyond Remission

Sun, 24 May 2026 11:00:00 EST

(Sun, 24 May 2026 )

Patients with Cushing's syndrome (CS) suffer from metabolic and cardiovascular comorbidities caused by hypercortisolism. The human gut microbiome responds to different pathological conditions.

https://cushings.invisionzone.com/topic/57884-altered-microbiome-signature-in-cushing%E2%80%99s-syndrome-persists-beyond-remission/

Amy Schumer, Steroid-Induced Cushing's

Mon, 25 May 2026 03:00:00 EST

(Mon, 25 May 2026 )

Schumer revealed she has exogenous Cushing syndrome, brought on by getting steroid injections that resulted in excess cortisol in her body. According to the Mayo Clinic, the condition can lead to weight gain, fatigue, “moon face,” headaches and other symptoms.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Mon, 25 May 2026 03:00:00 EST

(Mon, 25 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Efficacy And Safety of Osilodrostat In Patients With Ectopic Cushing´s Syndrome

Mon, 25 May 2026 04:00:00 EST

(Mon, 25 May 2026 )

Overall, osilodrostat controls hypercortisolism in approximately 90% of the patients with ECS and severe hypercortisolism and with normalization of UFC in 40% of cases after just 4 weeks of treatment. Therefore, osilodrostat should be considered as first-line treatment in patients with ECS, especially in patients with severe hypercortisolism.

https://cushings.invisionzone.com/topic/57930-efficacy-and-safety-of-osilodrostat-in-patients-with-ectopic-cushing%C2%B4s-syndrome/

Dee (Dee), Pituitary Bio

Mon, 25 May 2026 05:00:00 EST

(Mon, 25 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Mon, 25 May 2026 06:00:00 EST

(Mon, 25 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Mon, 25 May 2026 07:00:00 EST

(Mon, 25 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

A Medical Chart Audit to Assess Endocrinologist Perceptions of the Burden of Endogenous Cushing’s Syndrome

Mon, 25 May 2026 07:00:00 EST

(Mon, 25 May 2026 )

Sixty-nine endocrinologists abstracted data from 273 unique medical charts of patients with CS. Mean patient age was 46.5 ± 13.4 years, with a 60:40 (female:male) gender split. The mean duration of endogenous CS amongst patients was 4.1 years. Chart data indicated that patients experienced a high burden of comorbidities and symptoms, including fatigue, weight gain, and muscle weakness despite multi-modal treatment.

Changes in Clinical Features of Adrenal Cushing Syndrome

Mon, 25 May 2026 07:00:00 EST

(Mon, 25 May 2026 )

Adrenal Cushing syndrome (CS) has been rarely studied in recent years in Japan. This study aimed to investigate clinical characteristics and their changes over time in patients with adrenal CS.

https://cushings.invisionzone.com/topic/57834-changes-in-clinical-features-of-adrenal-cushing-syndrome/

What Was the Most Memorable Thing that Happened to YOU Last Year?

Mon, 25 May 2026 08:00:00 EST

(Mon, 25 May 2026 )

The Outcome of Abnormal Glucose Metabolism and Its Clinical Features in Patients With Cushing’s Disease After Curative Surgery

Mon, 25 May 2026 08:00:00 EST

(Mon, 25 May 2026 )

Cushing's patients demonstrated a high incidence of abnormal glucose metabolism. Notably, approximately two-thirds demonstrated improved glucose metabolism one year after curative surgery, with the greatest improvements observed at 3- to 6-month postoperative follow-up.

https://cushings.invisionzone.com/topic/57858-the-outcome-of-abnormal-glucose-metabolism-and-its-clinical-features-in-patients-with-cushing%E2%80%99s-disease-after-curative-surgery/#comment-479047

Severe Osteoporosis in a Young Man with Bilateral Cushing’s Syndrome

Mon, 25 May 2026 09:00:00 EST

(Mon, 25 May 2026 )

The diagnosis of Cushing’s syndrome is challenging; however, through the clinical picture and the search for secondary causes of osteoporosis, it was possible to reach the diagnosis of the case reported. There was an independent, symptomatic ACTH hypercortisolism manifested by typical phenotypic changes, severe secondary osteoporosis and arterial hypertension in a young patient.

The CuPeR Model: A Dynamic Online Tool for Predicting Cushing’s Disease Persistence and Recurrence After Pituitary Surgery

Mon, 25 May 2026 09:00:00 EST

(Mon, 25 May 2026 )

This study introduces the CuPeR model, an online dynamic nomogram developed to address these gaps by predicting postoperative outcomes in patients with CD undergoing pituitary surgery.

https://cushings.invisionzone.com/topic/57904-the-cuper-model-a-dynamic-online-tool-for-predicting-cushing%E2%80%99s-disease-persistence-and-recurrence-after-pituitary-surgery/

A More Accurate Diagnosis of Cushing’s Syndrome

Mon, 25 May 2026 10:00:00 EST

(Mon, 25 May 2026 )

Cushing's syndrome is associated with excessive cortisol production and, if left untreated, can result in severe complications, such as heart attacks, strokes, and type 2 diabetes. To diagnose this condition, a dexamethasone suppression test is commonly performed.

Ectopic Adrenocorticotrophic Hormone Syndrome in a 10-Year-Old Girl With a Thymic Neuroendocrine Tumor

Mon, 25 May 2026 10:00:00 EST

(Mon, 25 May 2026 )

Thymic neuroendocrine tumor as a cause of Cushing syndrome is extremely rare in children.

https://cushings.invisionzone.com/topic/57770-ectopic-adrenocorticotrophic-hormone-syndrome-in-a-10-year-old-girl-with-a-thymic-neuroendocrine-tumor/

Postoperative Initiation of Thromboprophylaxis in Patients with Cushing’s Disease (PIT-CD):

Mon, 25 May 2026 10:00:00 EST

(Mon, 25 May 2026 )

Pituitary surgical intervention remains the preferred treatment for Cushing’s disease (CD) while postoperative venous thromboembolism (VTE) is a significant risk. Whether to prescribe pharmacological thromboprophylaxis presents a clinical dilemma, balancing the benefit of reducing VTE risk with the potential for increasing hemorrhagic events in these patients. Currently, strong evidence and established protocols for routine pharmacological thromboprophylaxis in this population are lacking. Therefore, a randomized, controlled trial is warranted to determine the efficacy and safety of combined pharmacological and mechanical thromboprophylaxis in reducing postoperative VTE risk in patients with CD.

https://cushings.invisionzone.com/topic/57845-postoperative-initiation-of-thromboprophylaxis-in-patients-with-cushing%E2%80%99s-disease-pit-cd/

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Mon, 25 May 2026 10:00:00 EST

(Mon, 25 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Mon, 25 May 2026 11:00:00 EST

(Mon, 25 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Day 25, Cushing’s Awareness Challenge 2021

Mon, 25 May 2026 15:00:00 EST

(Mon, 25 May 2026 )

At NIH I set up a daily “routine” of sorts and listening to these tapes was a very important part of my day and helped me get through the ordeal of more testing, surgery, post-op and more.

When I had my kidney cancer surgery, those tapes were long broken and irreplaceable, but I had replaced all the songs – this time on my iPod.

Archived Interview: Dr. Dori Middleman, Pituitary Cushing’s Survivor

Mon, 25 May 2026 17:00:00 EST

(Mon, 25 May 2026 )

Dr. Dori Middleman is a Psychophamacologist, Certified Gestalt Psychotherapist and Cushing’s Patient.

She has had both pituitary surgery and two gamma knife radiosurgeries.

Listen at https://cushieblogger.com/2019/04/25/archived-interview-dr-dori-middleman-pituitary-cushings-survivor/

Interview with Donna Sellers, mother of a Cushing’s patient

Mon, 25 May 2026 17:00:00 EST

(Mon, 25 May 2026 )

Donna Sellers, President, John’s Foundation for Cushing’s Awareness, mother of a Cushing’s patient.

Listen at http://www.blogtalkradio.com/cushingshelp/2008/06/19/interview-with-donna-sellers-mother-of-a-cushings-patient

Add or update Your Bio

Tue, 26 May 2026 01:00:00 EST

(Tue, 26 May 2026 )

Please add your bio. Your information will help others.

A Case Report of Cushing’s Disease Presenting With Psychosis and Muscle Weakness Postpartum

Tue, 26 May 2026 03:00:00 EST

(Tue, 26 May 2026 )

The diagnosis of Cushing’s syndrome in pregnancy is often delayed because the symptoms overlap. We presented a thin 31-year-old woman, admitted 2 months after a normal-term delivery, with an atypical presentation of Cushing’s disease, unusual clinical features, and a challenging clinical course. She had no clinical discriminatory features of Cushing’s syndrome.

Choosing the Optimal Approach for Giant Pituitary Adenomas

Tue, 26 May 2026 03:00:00 EST

(Tue, 26 May 2026 )

As noted in a review published in the January 2024 issue of Operative Neurosurgery, endoscopic transnasal transsphenoidal surgery is increasingly applied to giant pituitary adenomas. 'We prefer this approach even when giant pituitary adenomas extend into the third ventricle because it's associated with lower postoperative morbidity and a higher likelihood of preserving normal pituitary and visual function,' Dr. Byrne says.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Tue, 26 May 2026 03:00:00 EST

(Tue, 26 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Basics: The Role of Endocrinology in Managing Polycystic Ovary Syndrome and Diabetes

Tue, 26 May 2026 05:00:00 EST

(Tue, 26 May 2026 )

Endocrinology is a complex field that requires a deep understanding of the endocrine system and its role in regulating the body’s hormones. An endocrinologist can help patients with PCOS and diabetes manage their conditions and achieve their health goals. By working with an endocrinologist, patients can get the help they need to manage their PCOS or diabetes and achieve their health goals.

Cushing's Syndrome Study, 45-minutes, 90 Dollars

Tue, 26 May 2026 05:00:00 EST

(Tue, 26 May 2026 )

We have an opportunity for you to take part in a Cushing's Syndrome Study for patients. Our project number for this study is KOV_12349.

Web-assisted telephone interview (you must be by a computer with high-speed internet access while on the phone during the time of the interview) - WEBCAM

Interview is 45-minutes long.

up to 90 Dollar Reward

https://cushings.invisionzone.com/topic/57923-cushings-syndrome-study-45-minutes-90-dollars/

Dee (Dee), Pituitary Bio

Tue, 26 May 2026 05:00:00 EST

(Tue, 26 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Myth: “You should be all better by now!”

Tue, 26 May 2026 06:00:00 EST

(Tue, 26 May 2026 )

Myth: “You should be all better by now! You found out what was wrong, you got the surgery, it’s been quite some time, and you are STILL not better?! You SHOULD have gotten better by now!” Chronic illness follows the same pattern as normal illness. You get diagnosed, treated, and then go back to a state of recovery, eventually leading you back to a state of “normal health”.

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Tue, 26 May 2026 06:00:00 EST

(Tue, 26 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Tue, 26 May 2026 07:00:00 EST

(Tue, 26 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Bilateral Co-Secretory Lesions Presenting with Coexisting Cushing Syndrome and Primary Aldosteronism

Tue, 26 May 2026 07:00:00 EST

(Tue, 26 May 2026 )

The case was a 45-year-old female from the adrenal disease diagnosis and treatment centre in West China Hospital of Sichuan University. The patient presented with hypertension, moon-shaped face, central obesity, fat accumulation on the back of the neck, disappearance of cortisol circadian rhythm, ACTH < 5 ng/L, failed elevated cortisol inhibition by dexamethasone, orthostatic aldosterone/renin activity > 30 (ng/dL)/(ng/mL/h), and plasma aldosterone concentration > 10 ng/dL after saline infusion testing.

Cushing’s Myths and Facts: “Vitamins and Natural Remedies can cure/heal Cushing’s”

Tue, 26 May 2026 08:00:00 EST

(Tue, 26 May 2026 )

Do you know how many people have told me that if I just “juice”, I will be cured from Cushing’s or Adrenal Insufficiency?! I appreciate the sentiment, but the sad reality is that no amount of juicing and no vitamin will cure Cushing’s. Some Cushing’s patients do take vitamins, some do eat raw food or paleo diets, and some even juice. However, this is just a lifestyle choice and not an attempt to cure Cushing’s.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Tue, 26 May 2026 10:00:00 EST

(Tue, 26 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Tue, 26 May 2026 11:00:00 EST

(Tue, 26 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

First-Episode Psychosis and Cushing Syndrome

Tue, 26 May 2026 11:00:00 EST

(Tue, 26 May 2026 )

Neuropsychiatric symptoms of Cushing syndrome are well documented, including irritability, anxiety, depressed mood, and cognitive impairment.

https://cushings.invisionzone.com/topic/57800-first-episode-psychosis-and-cushing-syndrome/

Utility of Intraoperative Ultrasound in Identifying Pituitary Adenoma Hidden Behind a Cystic Lesion in Cushing’s Disease

Tue, 26 May 2026 14:00:00 EST

(Tue, 26 May 2026 )

A 55-year-old female patient was referred from the endocrinology department for evaluation of Cushing’s disease. She had been on medication for hypertension and diabetes for the past seven years. Two months prior, she suffered an acute cerebral infarction, resulting in left-sided hemiparesis.

https://cushings.invisionzone.com/topic/57835-utility-of-intraoperative-ultrasound-in-identifying-pituitary-adenoma-hidden-behind-a-cystic-lesion-in-cushing%E2%80%99s-disease/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Wed, 27 May 2026 03:00:00 EST

(Wed, 27 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Atypical Presentation of Cushing’s Disease With Weight Loss and Hypokalemia

Wed, 27 May 2026 05:00:00 EST

(Wed, 27 May 2026 )

Learning points

Patients with CD do not always present with classical clinical features and may present with symptoms and biochemical findings that would otherwise suggest ectopic ACTH production.
While most patients with CD typically lose weight after biochemical remission, some patients gain weight after the normalization of cortisol levels.
This case highlights the need to entertain a broad differential in patients presenting with hypokalemia and weight loss and the need to exclude hypercortisolemia.

https://cushings.invisionzone.com/topic/57760-atypical-presentation-of-cushing%E2%80%99s-disease-with-weight-loss-and-hypokalemia/

Sterotherapeutics Announces First Patient Dosed in Phase 2 Clinical Trial Evaluating ST-002 for Cushing's Syndrome

Wed, 27 May 2026 05:00:00 EST

(Wed, 27 May 2026 )

A clinical-stage biopharmaceutical company focused on rare endocrine diseases, announced that the first patient has been successfully dosed in its ongoing Phase 2 clinical trial evaluating ST-002 for the treatment of Cushing's Syndrome.

https://cushings.invisionzone.com/topic/57846-sterotherapeutics-announces-first-patient-dosed-in-phase-2-clinical-trial-evaluating-st-002-for-cushings-syndrome/

Dee (Dee), Pituitary Bio

Wed, 27 May 2026 05:00:00 EST

(Wed, 27 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Cushing’s Disease Patients are More Likely to Have Ocular Hypertension

Wed, 27 May 2026 06:00:00 EST

(Wed, 27 May 2026 )

Ocular hypertension was more common in people with Cushing’s illness. The usage of steroids in the body is a major contributor to high intraocular pressure (IOP). Topical or systemic glucocorticoid use may increase the prevalence.

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Wed, 27 May 2026 06:00:00 EST

(Wed, 27 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Wed, 27 May 2026 07:00:00 EST

(Wed, 27 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Ectopic Adrenocorticotropic Hormone Production in a Stage IV Neuroendocrine Tumor: A Rare Presentation of Cushing's Syndrome

Wed, 27 May 2026 08:00:00 EST

(Wed, 27 May 2026 )

In this case, we describe a 54-year-old man with a stage IV NET with metastatic liver and pancreatic lesions, who presented with Cushing's syndrome due to ectopic ACTH production.

https://cushings.invisionzone.com/topic/57816-ectopic-adrenocorticotropic-hormone-production-in-a-stage-iv-neuroendocrine-tumor-a-rare-presentation-of-cushings-syndrome/

Jason T, Pituitary Bio

Wed, 27 May 2026 09:00:00 EST

(Wed, 27 May 2026 )

Jason is from England. Pituitary tumour found in 2020(posterior lobe),now test after test and 2nd MRI still shows microadenoma. He also had two traumatic brain injuries.

What Is The Life Expectancy Of Someone With Cushing's Syndrome?

Wed, 27 May 2026 09:00:00 EST

(Wed, 27 May 2026 )

Complications of Cushing's syndrome include Hypertension, DM, infection, Bone fracture, mood swings, memory loss. If left untreated then life expectancy would be around 5 years.

Emergence of De Novo Conditions Following Remission of Cushing Syndrome: A Case Report and Scoping Review

Wed, 27 May 2026 10:00:00 EST

(Wed, 27 May 2026 )

Our scoping review identified several cases of de novo conditions emerging following the remission of Cushing syndrome. They occurred mostly in women and within the year following remission.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Wed, 27 May 2026 10:00:00 EST

(Wed, 27 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Changing face of Cushing’s Disease Over Three Decades in Pituitary Center

Wed, 27 May 2026 10:00:00 EST

(Wed, 27 May 2026 )

As the clinical presentation of Cushing’s disease changes over time, waiting for the typical Cushing’s clinic can delay diagnosis. It is important that clinicians take this into account when they suspect CD.

https://cushings.invisionzone.com/topic/57886-changing-face-of-cushing%E2%80%99s-disease-over-three-decades-in-pituitary-center/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Wed, 27 May 2026 11:00:00 EST

(Wed, 27 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Paraneoplastic Cushing Syndrome Unmasking Small Cell Lung Cancer: A Rare Presentation

Wed, 27 May 2026 15:00:00 EST

(Wed, 27 May 2026 )

We present a case of a middle-aged woman who presented with chest pain and shortness of breath. Laboratory tests revealed persistent hypokalaemia, hyperglycaemia, and metabolic alkalosis despite treatment. Imaging identified a mass near the right hilum suggestive of lung malignancy. Endocrine evaluation showed markedly elevated cortisol and adrenocorticotropic hormone levels, consistent with paraneoplastic Cushing syndrome caused by ectopic hormone production.

https://cushings.invisionzone.com/topic/57869-paraneoplastic-cushing-syndrome-unmasking-small-cell-lung-cancer-a-rare-presentation/

A Challenging Case of Severe Cushing’s Syndrome in the Course of Metastatic Thymic Neuroendocrine Carcinoma with a Synchronous Adrenal Tumor

Wed, 27 May 2026 17:00:00 EST

(Wed, 27 May 2026 )

Endogenous Cushing’s syndrome (CS) is a rare endocrine condition caused by excess cortisol production with an annual incidence of 0.2–5 cases per million people

Media Attention! Cushing's on Today

Thu, 28 May 2026 02:00:00 EST

(Thu, 28 May 2026 )

Blood tests and an MRI finally confirmed the doctor’s suspicion: Yawn had a tumor in her pituitary gland — a pea-size organ at the base of the brain — that was causing the gland to release too much adrenocorticotropic hormone. That, in turn, flooded her body with cortisol, a steroid hormone that’s normally released in response to stress or danger. The resulting condition is called Cushing disease.

Video of Transsphenoidal Surgery

Thu, 28 May 2026 03:00:00 EST

(Thu, 28 May 2026 )

The Case Records of the Mayo Clinic Florida Neurosurgery featured an endoscopic transsphenoidal approach for a pituitary tumor resection.

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Thu, 28 May 2026 03:00:00 EST

(Thu, 28 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Disease Remission and Surgical Outcomes of Endoscopic Transsphenoidal Surgery for Cushing Disease: A Single Center Experience

Thu, 28 May 2026 04:00:00 EST

(Thu, 28 May 2026 )

Transsphenoidal surgery is the primary treatment for patients with Cushing disease (CD). This study assessed the surgical and endocrinologic outcomes of patients with CD following endoscopic pituitary surgery using strict biochemical criteria to guide surveillance in patients not achieving early remission.

https://cushings.invisionzone.com/topic/57943-disease-remission-and-surgical-outcomes-of-endoscopic-transsphenoidal-surgery-for-cushing-disease-a-single-center-experience/

Dee (Dee), Pituitary Bio

Thu, 28 May 2026 05:00:00 EST

(Thu, 28 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Thu, 28 May 2026 06:00:00 EST

(Thu, 28 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Sterotherapeutics begins Phase II trial for ST-002 targeting Cushing’s Syndrome

Thu, 28 May 2026 06:00:00 EST

(Thu, 28 May 2026 )

The trial will assess the drug's efficacy, tolerability, and safety in individuals with Cushing's.

https://cushings.invisionzone.com/topic/57785-sterotherapeutics-begins-phase-ii-trial-for-st-002-targeting-cushing%E2%80%99s-syndrome/

📰 Clinical and Surgical Outcomes of Pediatric Cushing’s Disease Following Endoscopic Transsphenoidal Surgery

Thu, 28 May 2026 06:00:00 EST

(Thu, 28 May 2026 )

Cushing’s disease (CD) is characterized by hypercortisolism due to excessive adrenocorticotropic hormone (ACTH) secretion from a pituitary adenoma. Though more common in adults, pediatric cases constitute approximately 5% of those seen in adults. Early diagnosis and treatment are critical due to the severe impacts on growth and development in children. Endoscopic transsphenoidal surgery (ETSS) is the preferred first-line treatment for both children and adults.

https://cushings.invisionzone.com/topic/57801-clinical-and-surgical-outcomes-of-pediatric-cushing%E2%80%99s-disease-following-endoscopic-transsphenoidal-surgery/

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Thu, 28 May 2026 07:00:00 EST

(Thu, 28 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Basics: Meds: Recorlev

Thu, 28 May 2026 10:00:00 EST

(Thu, 28 May 2026 )

Recorlev was approved by the FDA in December 2021 to treat those Cushing’s patients for whom surgery is not a choice or has failed to lower cortisol levels.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Thu, 28 May 2026 10:00:00 EST

(Thu, 28 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Sparrow Pharmaceuticals Announces Completion of Phase 2 Trial and FDA Orphan Drug Designation of Clofutriben for Endogenous Cushing’s Syndrome

Thu, 28 May 2026 11:00:00 EST

(Thu, 28 May 2026 )

HSD-1 inhibition with clofutriben is a completely novel approach to the treatment of endogenous Cushing’s syndrome that may overcome many of the serious problems with current therapies, including major safety, tolerability, and complexity issues such as the risk of adrenal insufficiency and adrenal crisis.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Thu, 28 May 2026 11:00:00 EST

(Thu, 28 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Cardiometabolic Complications After Cushing’s Disease Remission

Thu, 28 May 2026 11:00:00 EST

(Thu, 28 May 2026 )

Cushing’s disease (CD) is associated with phenotypic traits and comorbidities that may persist after the normalization of cortisol levels. Medical therapy is usually given in recurrent or persistent CD after transsphenoidal surgery. We aimed to investigate the impact of long-term normalization of daily cortisol secretion on clinical picture and cardiometabolic comorbidities, comparing surgical remission to medical treatment.

https://cushings.invisionzone.com/topic/57817-cardiometabolic-complications-after-cushing%E2%80%99s-disease-remission/

Cancer risk elevated for adults after Cushing’s syndrome diagnosis

Thu, 28 May 2026 14:00:00 EST

(Thu, 28 May 2026 )

I certainly know this to be true I'm an 18 year survivor of yet another disease that I shouldn't have gotten: kidney cancer.

https://cushings.invisionzone.com/topic/57758-cancer-risk-elevated-for-adults-after-cushing%E2%80%99s-syndrome-diagnosis/

Trish, Steroid-Induced Bio

Thu, 28 May 2026 17:00:00 EST

(Thu, 28 May 2026 )

She got Cushing’s Syndrome from abundant steroid injections due to a severe back injury and it has rendered her “comatose”. She has no energy, she sleeps all the time, and I miss her and am lonely when she is in this state, which is all the time.

https://cushingsbios.com/2025/11/28/trish-steroid-induced-bio/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Fri, 29 May 2026 03:00:00 EST

(Fri, 29 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Crinetics Pharma’s Promising Study on CRN04894 for Cushing’s Syndrome: A Potential Game-Changer?

Fri, 29 May 2026 03:00:00 EST

(Fri, 29 May 2026 )

Crinetics Pharmaceuticals is conducting a study titled ‘A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing’s Syndrome.’ This study aims to evaluate the safety, tolerability, and pharmacokinetics of CRN04894, an ACTH receptor antagonist, in treating Cushing’s Syndrome, a condition characterized by excessive cortisol production. The study’s significance lies in its potential to offer a new treatment avenue for patients with Cushing’s disease or Ectopic ACTH Syndrome.

https://cushings.invisionzone.com/topic/57905-crinetics-pharma%E2%80%99s-promising-study-on-crn04894-for-cushing%E2%80%99s-syndrome-a-potential-game-changer/

Cushing's Syndrome in Pregnancy in Which Laparoscopic Adrenalectomy was Safely Performed by a Retroperitoneal Approach

Fri, 29 May 2026 04:00:00 EST

(Fri, 29 May 2026 )

Laparoscopic adrenalectomy is the standard treatment for adrenal tumors caused by Cushing's syndrome. However, few pregnant women have undergone adrenalectomy because of the risk of general anesthesia and surgery.

Delayed Diagnosis of Ectopic Cushing Syndrome

Fri, 29 May 2026 04:00:00 EST

(Fri, 29 May 2026 )

While many patients with Cushing syndrome have a delayed diagnosis, this case highlights the critical need to increase awareness of the signs and symptoms of hypercortisolism and to improve the understanding of appropriate screening tests among nonendocrine providers.

Dee (Dee), Pituitary Bio

Fri, 29 May 2026 05:00:00 EST

(Fri, 29 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Fri, 29 May 2026 06:00:00 EST

(Fri, 29 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Fri, 29 May 2026 07:00:00 EST

(Fri, 29 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

A Second Look at Cushing Disease: Hypercortisolism Recurrence From Another Gland

Fri, 29 May 2026 07:00:00 EST

(Fri, 29 May 2026 )

Cushing disease (CD) is the most common form of adrenocorticotropin (ACTH)-dependent Cushing syndrome (CS), whereas unilateral adrenal adenoma is the most common cause of ACTH-independent CS. However, the occurrence of different subtypes of CS in a single individual is very rare.

https://cushings.invisionzone.com/topic/57836-a-second-look-at-cushing-disease-hypercortisolism-recurrence-from-another-gland/

Basics: Testing: Dex Tests

Fri, 29 May 2026 08:00:00 EST

(Fri, 29 May 2026 )

Dexamethasone suppression test measures whether adrenocorticotrophic hormone (ACTH) secretion by the pituitary can be suppressed.

How the Test is Performed

During this test, you will receive dexamethasone. This is a strong man-made (synthetic) glucocorticoid medicine. Afterward, your blood is drawn so that the cortisol level in your blood can be measured.

Cushing's: A comprehensive guide to understanding a devastating condition

Fri, 29 May 2026 09:00:00 EST

(Fri, 29 May 2026 )

By Dr. Lewis Blevins: This book is perhaps something a little different than most would expect. Firstly, it's a single-author book on Cushing's syndrome. It is not, like most textbooks, a compendium of edited submissions from multiple authors where there are often divergent opinions from one chapter to the next. Instead, it's a treatise reflecting my education and experience. It is not referenced but instead each chapter is followed by suggested readings. It represents my thoughts, understanding and a personal reflection on a career of evaluating a multitude of patients suspected of having the disorder and treating those confirmed to have hypercortisolism due to one cause or another. It reflects my perspectives of the art and science of the field.

More info at https://cushings.invisionzone.com/topic/57752-cushings-a-comprehensive-guide-to-understanding-a-devastating-condition/

Seliciclib for the Treatment of Cushing’s Disease Targeting Pituitary

Fri, 29 May 2026 10:00:00 EST

(Fri, 29 May 2026 )

Seliciclib (R-roscovitine) has been shown in preclinical studies to inhibit neoplastic corticotroph proliferation and the production of adrenocorticotropic hormone (ACTH) in the pituitary gland. Therefore, for a study, researchers sought to investigate the effectiveness of seliciclib as a pituitary-targeting treatment for patients with Cushing’s disease (CD).

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Fri, 29 May 2026 10:00:00 EST

(Fri, 29 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Unveiling the Uncommon: Cushing’s Syndrome (CS) Masquerading as Severe Hypokalemia

Fri, 29 May 2026 11:00:00 EST

(Fri, 29 May 2026 )

A 48-year-old male with a history of hypertension presented to his primary care physician with complaints of bilateral leg swelling, occasional shortness of breath, dizziness, and a general feeling of malaise persisting for 10 days. The patient reported increased water intake and urinary frequency without dysuria. The patient was diagnosed with hypertension eight months ago. He experienced progressive muscle weakness over two months, hindering his ability to perform daily activities, including using the bathroom.

Cushing’s Syndrome Masquerading as Fibromyalgia: A Case Series

Fri, 29 May 2026 11:00:00 EST

(Fri, 29 May 2026 )

Three young female patients with a history of generalized body pain were diagnosed with fibromyalgia. They visited several specialities which related patients' symptoms to their previous diagnosis of fibromyalgia and were treated symptomatically. These patients developed a multitude of clinical features including fractures, hypertension, abnormal weight gain, proximal myopathic pain and bruising. They were seen by rheumatologists whose assessment was that their clinical features were not entirely due to fibromyalgia and suspected that patients have a possible underlying endocrine cause. Patients were referred to an endocrinologist for further tests with suspicion of Cushing’s syndrome. Laboratory tests and imaging confirmed a diagnosis of Cushing’s syndrome. Two of them had adrenal adenoma and one had iatrogenic corticosteroid use. These cases emphasize the need for thorough clinical evaluation for patients who are thought to have fibromyalgia. Fibromyalgia is a diagnosis of exclusion.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Fri, 29 May 2026 11:00:00 EST

(Fri, 29 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Double Synchronous Functional Pituitary Adenomas Causing Acromegaly and Subclinical Cushing Disease.

Fri, 29 May 2026 16:00:00 EST

(Fri, 29 May 2026 )

We report the case of a patient with double functional pituitary adenomas causing acromegaly and subclinical Cushing's disease. A 45-year-old woman was referred to our Department for suspected acromegaly. Her past medical history included diabetes mellitus treated with oral antidiabetic drugs and hypertension.

https://cushings.invisionzone.com/topic/57847-double-synchronous-functional-pituitary-adenomas-causing-acromegaly-and-subclinical-cushing-disease/

The Effect of Hypercortisolism Treatment on Dyslipidemia in Cushing Syndrome

Fri, 29 May 2026 17:00:00 EST

(Fri, 29 May 2026 )

Our study demonstrate a significant improvement in serum lipid levels after treatment of Cushings Syndrome. Since the cardiovascular complications of hypercortisolism depend on several factors, further studies are needed to determine whether this directly translates into an adequate reduction in the risk of major cardiovascular events.

https://cushings.invisionzone.com/topic/57931-the-effect-of-hypercortisolism-treatment-on-dyslipidemia-in-cushing-syndrome/

Laura, In The Media

Fri, 29 May 2026 18:00:00 EST

(Fri, 29 May 2026 )

Cushing's has appeared several times in the media. Jayne Kerns encouraged Zastrow to check out a Cushing's Web site, which Zastrow did. Every symptom listed matched her condition. Her doctor ran some tests, and the results confirmed Zastrow had Cushing's, a hormonal disorder often brought on by a tumor.

https://cushingsbios.com/2025/11/29/laura-in-the-media/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sat, 30 May 2026 03:00:00 EST

(Sat, 30 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dee (Dee), Pituitary Bio

Sat, 30 May 2026 05:00:00 EST

(Sat, 30 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sat, 30 May 2026 06:00:00 EST

(Sat, 30 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Janet (janetelizabeth), Adrenal Bio

Sat, 30 May 2026 06:00:00 EST

(Sat, 30 May 2026 )

I have recently been diagnosed with cushings syndrome and awaiting removal of gland and tumour.

https://cushingsbios.com/2025/11/07/janet-janetelizabeth-adrenal-bio/

In Memory of Sherry Carlson ~ May 30, 2020

Sat, 30 May 2026 07:00:00 EST

(Sat, 30 May 2026 )

Sherry passed away this afternoon, naturally and peacefully in her sleep.

She loved her community and we know how grateful she was to every one of her friends on here for the genuine love and support she’s received over the years.

Testing Vitamin B3

Sat, 30 May 2026 07:00:00 EST

(Sat, 30 May 2026 )

Since I just had Mohs surgery for squamous cell carcinoma, I immediately went to amazon to search for nicotinamide.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sat, 30 May 2026 07:00:00 EST

(Sat, 30 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

What Was the Most Memorable Thing that Happened to YOU Last Year?

Sat, 30 May 2026 08:00:00 EST

(Sat, 30 May 2026 )

Home cortisol tests: 3 of the best

Sat, 30 May 2026 09:00:00 EST

(Sat, 30 May 2026 )

There are several home cortisol tests available to purchase over the counter or online. These allow a person to take a sample of blood, urine, or saliva before sending it off for analysis.

After taking a home cortisol test, people can usually receive their results within 2–5 days online or via a telephone call with a healthcare professional.

However, there are currently no studies investigating the reliability of these home cortisol tests. Therefore, people should follow up on their test results with a healthcare professional.

Treatments: Adrenalectomy and BLA (Bilateral adrenalectomy)

Sat, 30 May 2026 09:00:00 EST

(Sat, 30 May 2026 )

Some pain is normal after any surgery. Different people have different levels of sensitivity to pain. In general, you should experience a little less pain every day. Pain is usually worse in the evening when you are trying to go to sleep. Do not be afraid to take the pain medicine prescribed for you, particularly before you go to sleep, but you can stop taking it if you are comfortable. Most pain medications cause constipation and they can also cause drowsiness. Do not drive or operate power tools after you take narcotic pain medications. If you have only mild discomfort, try taking extra-strength Tylenol® as directed.

https://cushings-help.com/2024/10/30/adrenalectomy-and-bla/

A Second Look at Refractory Edema: Delayed Diagnosis of Paraneoplastic Cushing’s Syndrome in Small Cell Lung Cancer

Sat, 30 May 2026 09:00:00 EST

(Sat, 30 May 2026 )

Paraneoplastic Cushing syndrome (PCS) is a rare manifestation of ectopic adrenocorticotropic hormone (ACTH) production, mostly associated with bronchial carcinoid and small cell lung cancer (SCLC).

https://cushings.invisionzone.com/topic/57932-a-second-look-at-refractory-edema-delayed-diagnosis-of-paraneoplastic-cushing%E2%80%99s-syndrome-in-small-cell-lung-cancer/

Video: Morning Medical Update - Cushing's Disease

Sat, 30 May 2026 09:00:00 EST

(Sat, 30 May 2026 )

Cushing's Disease can be treated, but only with the right doctor and diagnosis.

We explore the barriers that make some patients endure years of symptoms before finding relief.

https://cushings.invisionzone.com/topic/57933-morning-medical-update-cushings-disease/

Environmental Issues and Cushing’s

Sat, 30 May 2026 09:00:00 EST

(Sat, 30 May 2026 )

Scientists now tell us there is something in our waters that we least expected.

That “something” is a class of chemicals called endocrine disruptors, and Dr. Vicki Blazer, a fisheries biologist at the United States Geological Survey, thinks the chemicals are responsible for the high concentrations of intersex fish found in the Potomac, and other rivers in the mid-Atlantic.

https://cushieblog.com/2025/12/30/environmental-issues-and-cushings/

Call 911! Adrenal Crisis, Addison's/Adrenal Insufficiency

Sat, 30 May 2026 10:00:00 EST

(Sat, 30 May 2026 )

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Dana, Undiagnosed Bio

Sat, 30 May 2026 10:00:00 EST

(Sat, 30 May 2026 )

Well, I'm 29 now and still undiagnosed. If Cushing's is what's wrong with me, I have had it for quite a long time. I gained a lot of weight (60 lbs) the last 2 years of high school (17-18 years old). I lost 30 lbs at age 19 (I just didn't eat much) and have since gained 70 lbs.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sat, 30 May 2026 10:00:00 EST

(Sat, 30 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sat, 30 May 2026 11:00:00 EST

(Sat, 30 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Adrenal Cushing’s Syndrome in Pregnancy Complicated by Fetal Growth Restriction Following Retroperitoneoscopic Adrenalectomy

Sat, 30 May 2026 16:00:00 EST

(Sat, 30 May 2026 )

A 29-year-old Japanese pregnant woman, G5P3A1, conceived spontaneously and was referred to our hospital because of uncontrolled hypertension at 24 weeks of gestation. On admission, she presented with physical findings characteristic of Cushing's syndrome (CS), such as moon face, buffalo hump, and reddish-purple striae. Laboratory examination revealed hyperglycemia and hypercortisolism with suppressed adrenocorticotropic hormone levels. Imaging studies revealed a right adrenocortical adenoma, and the patient was clinically diagnosed with adrenal CS.

https://cushings.invisionzone.com/topic/57924-adrenal-cushing%E2%80%99s-syndrome-in-pregnancy-complicated-by-fetal-growth-restriction-following-retroperitoneoscopic-adrenalectomy/

Clinical Features, Diagnosis and Treatment Outcomes of Cushing's Disease In Children: a Multicenter Study

Sat, 30 May 2026 17:00:00 EST

(Sat, 30 May 2026 )

Herein, national data of the clinical experience on paediatric CD have been presented. Our findings highlight that presenting complaints may be subtle in children, the sensitivities of the diagnostic tests are very variable and require a careful interpretation, and MRI fails to detect adenoma in approximately one-third of cases. Finally, clinicians should be aware of the recurrence of the disease during the follow-up after surgery.

Reconstructive Liposuction for Residual Lipodystrophy After Remission of Cushing’s Disease

Sat, 30 May 2026 18:00:00 EST

(Sat, 30 May 2026 )

We report a case of a 16-year-old female with recurrent Cushing’s disease secondary to a pituitary microadenoma, confirmed by elevated urinary free cortisol and magnetic resonance imaging (MRI). It was initially treated with transsphenoidal resection in 2019; disease recurrence was confirmed and again treated in 2024.

https://cushings.invisionzone.com/topic/57848-reconstructive-liposuction-for-residual-lipodystrophy-after-remission-of-cushing%E2%80%99s-disease/

Voices from the Past: Laura F, Undiagnosed Bio

Sat, 30 May 2026 18:00:00 EST

(Sat, 30 May 2026 )

I’ve been gaining weight for about 3 1/2 yrs since having my thyroid removed due to a 25 yr old nodule that was calcified. My thyroid levels have always been good, before and after removal. There were A typical cells in the nodule, that’s why they advised removing the thyroid.

As I gain weight and have lumps of inflammation now over all of my body, all I have been told is to eat less and exercise more. Even though I have told my drs that I barely eat at all.

https://cushingsbios.com/2025/11/30/laura-f-undiagnosed-bio/

Cushing’s, Cancer and Other Serious Diseases

Sat, 30 May 2026 18:00:00 EST

(Sat, 30 May 2026 )

I was drawn to this blog post because the author mentioned that she had both Cushing’s and cancer, a kind of unusual combination.

1974 to Today: Seal it up
By Experience
I still haven’t heard what the consensus is on my aftercare: Cushing’s and Cancer. I don’t know what I will be expecting to feel like after surgery. My endocrinologist said that I should get sick after the surgery and need some kind of …
1974 to Today – http://1974totoday.blogspot.com/

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Sun, 31 May 2026 03:00:00 EST

(Sun, 31 May 2026 )

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Pregnancy Case: Cushing’s Syndrome with Diabetes Insipidus

Sun, 31 May 2026 04:00:00 EST

(Sun, 31 May 2026 )

Cushing's Syndrome, a rare but complex endocrine disorder characterized by excessive cortisol production, presents unique challenges and risks during pregnancy. Recent advancements in medical understanding have led to greater awareness of the implications of this syndrome when coupled with conditions like diabetes insipidus, particularly in pregnant patients. The coexistence of these disorders emphasizes the need for a multidisciplinary approach to manage these high-risk pregnancies effectively.

https://cushings.invisionzone.com/topic/57872-pregnancy-case-cushing%E2%80%99s-syndrome-with-diabetes-insipidus/

Dee (Dee), Pituitary Bio

Sun, 31 May 2026 05:00:00 EST

(Sun, 31 May 2026 )

After a hormone panel, my doctor told me I was in menopause.

At this time, the whites of my eyes started hemorrhaging and my skin became paper thin, bleeding and bruising. I was tested for Von Willebrands which came back negative.

https://cushingsbios.com/2026/05/04/dee-dee-pituitary-bio/

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sun, 31 May 2026 06:00:00 EST

(Sun, 31 May 2026 )

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Sun, 31 May 2026 07:00:00 EST

(Sun, 31 May 2026 )

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Sun, 31 May 2026 10:00:00 EST

(Sun, 31 May 2026 )

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Three Cases of Ectopic, Cyclic Cushing Syndrome: A New Square Wave Variant

Sun, 31 May 2026 10:00:00 EST

(Sun, 31 May 2026 )

Cyclic Cushing syndrome (CCS) is a rare variant of Cushing syndrome (CS) characterized by intermittent episodes of cortisol peaks alternating with variable periods of normal or subnormal adrenocorticotropic hormone (ACTH) and cortisol levels.

https://cushings.invisionzone.com/topic/57906-three-cases-of-ectopic-cyclic-cushing-syndrome-a-new-square-wave-variant/

What Is Facial Plethora?

Sun, 31 May 2026 11:00:00 EST

(Sun, 31 May 2026 )

Facial plethora is a main symptom of Cushing syndrome, a rare condition that’s caused by high levels of cortisol, known as the stress hormone.

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Sun, 31 May 2026 11:00:00 EST

(Sun, 31 May 2026 )

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Cushing Syndrome and Hormone Disorders

Sun, 31 May 2026 18:00:00 EST

(Sun, 31 May 2026 )

In our Daily Dose, a viewer is asking about hormone problems that can cause your face to become round. Dr. Lacy Anderson joined News 9 to explain how some hormone disorders, like Cushing syndrome work.

FDA Declines to Approve Relacorilant for Hypertension Linked to Hypercortisolism

Sun, 31 May 2026 18:00:00 EST

(Sun, 31 May 2026 )

“We are surprised and disappointed by this outcome,” Joseph K. Belanoff, MD, CEO of Corcept Therapeutics, said in a press release. “Our commitment to patients suffering from the effects of hypercortisolism is unwavering. I am confident we will find a way to get relacorilant to the patients it could help. We will meet with the FDA as soon as possible to discuss the best path forward.”

https://cushings.invisionzone.com/topic/57934-fda-declines-to-approve-relacorilant-for-hypertension-linked-to-hypercortisolism/

Ketoconazole As Second-Line Treatment for Cushing’s Disease After Transsphenoidal Surgery

Sun, 31 May 2026 19:00:00 EST

(Sun, 31 May 2026 )

The first-line treatment for Cushing’s disease is transsphenoidal surgery for pituitary tumor resection. Ketoconazole has been used as a second-line drug despite limited data on its safety and efficacy for this purpose.

Cushie Calendar (Cushie)

In Memory of Kathryn McBride 'Bridie' Miller ~ May 1, 2007

Investigational Cushing’s Syndrome Medication Reduces BP, Glucose in Open-Label Trial

Ivory Tower: New PET Scan Molecule Offers Breakthrough in Detecting Cushing’s Syndrome

Ectopic ACTH-secreting Pheochromocytoma Without Typical Signs of Cushing Syndrome

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Liver impairment and medical management of Cushing Syndrome and MACSProvisionally

Global Longitudinal Strain Reduction With Apical Sparing in Cushing Syndrome-Related Heart Failure With Preserved Ejection Fraction (HFpEF)

Basics: What Causes Abnormal Cortisol Levels?

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Sleep Impairment Similar in Cushing Syndrome, Mild Autonomous Cortisol Secretion

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

“The Healthcare System Did Fail Me Repeatedly”: a Qualitative Study On Experiences Of Healthcare Among Canadian Women With Cushing’s Syndrome

Comment added to Day 1: Cushing's Awareness Challenge 2024

The STUB1-TPIT Axis Regulates the Secretion of Adrenocorticotrophic Hormone in Cushing Disease

Adults with Cushing’s Syndrome Report High Burden Of Illness, Despite Ongoing Treatment

Adrenocorticotropic Hormone-Dependent Cushing's Syndrome Complicated With Gastric Ulcer Perforation in a 30-Year-Old Saudi Female

Cardiac Magnetic Resonance Reveals Biventricular Impairment In Cushing’s Syndrome

Impact of Remission Status in Endogenous Cushing's Syndrome on Cancer Incidence

TikTok Saved My Life: Student Discovers Life-threatening Tumour After Self-diagnosing Rare Condition

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

A Silent Invader: Asymptomatic Rhodococcus Infection Unmasked In a Patient With Ectopic ACTH-Dependent Cushing’s Syndrome

Pituitary Surgery Outcome in Patients 75 Years and Older

Corcept’s relacorilant GRADIENT trial misses primary endpoint

Oncocytic Pituicytoma in a Patient with Cushing's Disease

How is Cushing's Disease Diagnosed?

What Do *You* Think? Alternate Treatments

In Memory of Patti ~ May 2, 2002

PET/MRI may improve diagnosis of Cushing disease

Myocardial Work Impairment in Patients With Cushing’s Syndrome

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Preop TT3 Predicts HPA Axis Recovery After Cushing Surgery

Cushing's Syndrome Presenting as Non-Atherosclerotic Myocardial Infarction and Heart Failure

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Anonymous Woman, Recurrent Cushing's

Janet (janetelizabeth), Adrenal Bio

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Comment added to Day 2, Cushing’s Awareness Challenge

What Was the Most Memorable Thing that Happened to YOU Last Year?

Accidental Cushing Syndrome

Cushing's Basics: What is Cortisol?

Prevalence of Nelson’s Syndrome After Bilateral Adrenalectomy in Patients with Cushing’s Disease

Call 911! Adrenal Crisis, Addison's/Adrenal Insufficiency

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Comment added to Day 3: Cushing’s Awareness Challenge

Ectopic Adrenocorticotropic Hormone-Secreting Pheochromocytoma with Severe Metabolic Disturbances: A Case Report

Adrenal insufficiency Basics

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Cushing’s Myths and Facts

Diabetic Ketoacidosis as the First Manifestation of Ectopic Cushing’s Syndrome

Xeris Presents New Post Hoc Analysis on Effects of Levoketoconazole (Recorlev®) in Cushing’s Syndrome Patients at ENDO 2024

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Hypercoagulability in Cushing Syndrome

Kind Words for Cushing’s Awareness Month

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Research Study for Patients Diagnosed with Cushing's Disease and Their Caregivers

Video: Cushing’s Disease-Pituitary Gland

Unilateral Adrenalectomy for Pediatric Cyclical Cushing Syndrome With Novel PRKAR1A Variant Associated Carney Complex

Corcept Completes Enrollment in Phase 3 Gradient Trial of Relacorilant in Patients With Adrenal Cushing’s Syndrome

Exogenous Cushing Syndrome and Hip Fracture Due to Over-the-Counter Supplement (Artri King)

Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease

Thymic Neuroendocrine Tumor With Metastasis to the Breast Causing Ectopic Cushing’s Syndrome

Sabrina, Undiagnosed Bio

FDA Grants Breakthrough Therapy Designation for Oral Congenital Adrenal Hyperplasia Drug

What Was the Most Memorable Thing that Happened to YOU Last Year?

Basics: The Pituitary Gland: Small But Mighty

Complete and Sustained Remission of Hypercortisolism With Pasireotide Treatment of an Adrenocorticotropic Hormone (Acth)-Secreting Thoracic Neuroendocrine Tumour: an N-Of-1 Trial

Fulminant Ectopic Cushing’s Syndrome Caused by Metastatic Small Intestine Neuroendocrine Tumour

Restoration of Intra-patient Variability and Diurnal Range of ACTH with Remission in Cushing’s Disease

Can you Help? Cyclic Cushing's?

‘Cortisol Face’ Is Real, But It’s Not As Common As You Might Think

Graphic Era Hospital’s Milestone Treatment of Two Complex Cases

Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease

Oncocytic Pituicytoma in a Patient with Cushing's Disease

Connecting Canine and Human Health to Fight Cushing’s Disease

Adrenal Insufficiency Common After Adrenalectomy for Mild Autonomous Cortisol Secretion

What Do You Think? Alternate Treatments

What Do You Think? Only One Urine Test for Cushing's?